Long-term prognosis of patients with J-wave syndrome
| العنوان: | Long-term prognosis of patients with J-wave syndrome |
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| المؤلفون: | Naohiko Takahashi, Kenji Yodogawa, Kengo Fukushima Kusano, Tsukasa Kamakura, Takeshi Aiba, Minoru Horie, Wataru Shimizu, Yasuya Inden, Tetsuji Shinohara, Hiroshi Morita, Nobuyuki Murakoshi, Akihiko Nogami |
| المصدر: | Heart. 106:299-306 |
| بيانات النشر: | BMJ, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, medicine.medical_treatment, Provocation test, Cardiac Conduction System Disease, Japan, Recurrence, Internal medicine, medicine, Humans, ST segment, Brugada Syndrome, Proportional Hazards Models, Retrospective Studies, J wave, Brugada syndrome, business.industry, Incidence (epidemiology), Retrospective cohort study, Middle Aged, Prognosis, Implantable cardioverter-defibrillator, medicine.disease, Defibrillators, Implantable, Death, Sudden, Cardiac, Ventricular Fibrillation, Ventricular fibrillation, Tachycardia, Ventricular, Cardiology, Female, Cardiology and Cardiovascular Medicine, business, Anti-Arrhythmia Agents |
| الوصف: | ObjectiveLimited data are currently available regarding the long-term prognosis of patients with J-wave syndrome (JWS). The aim of this study was to investigate the long-term prognosis of patients with JWS and identify predictors of the recurrence of ventricular fibrillation (VF).MethodsThis was a multicentre retrospective study (seven Japanese hospitals) involving 134 patients with JWS (Brugada syndrome (BrS): 85; early repolarisation syndrome (ERS): 49) treated with an implantable cardioverter defibrillator. All patients had a history of VF. All patients with ERS underwent drug provocation testing with standard and high intercostal ECG recordings to rule out BrS. The impact of global J waves (type 1 ECG or anterior J waves and inferolateral J waves in two or more leads) on the prognosis was evaluated.ResultsDuring the 91±66 months of the follow-up period, 52 (39%) patients (BrS: 37; ERS: 15) experienced recurrence of VF. Patients with BrS and ERS with global J waves showed a significantly higher incidence of VF recurrence than those without (BrS: log-rank, p=0.014; ERS: log-rank, p=0.0009). The presence of global J waves was a predictor of VF recurrence in patients with JWS (HR: 2.16, 95% CI 1.21 to 3.91, p=0.0095), while previously reported high-risk electrocardiographic parameters (high-amplitude J waves ≥0.2 mV and J waves associated with a horizontal or descending ST segment) were not predictive of VF recurrence.ConclusionsThis multicentre long-term study showed that the presence of global J waves was associated with a higher incidence of VF recurrence in patients with JWS. |
| تدمد: | 1468-201X 1355-6037 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ee6b3286a9febbe0f3d99a67641bd4bTest https://doi.org/10.1136/heartjnl-2019-315007Test |
| رقم الانضمام: | edsair.doi.dedup.....1ee6b3286a9febbe0f3d99a67641bd4b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1468201X 13556037 |
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