المؤلفون: López Gómez, María Andrée, Gundersen, Daniel A, Boden, Leslie I, Sorensen, Glorian, Katz, Jeffrey N, Collins, Jamie E, Wagner, Gregory, Vriniotis, Mary G, Williams, Jessica AR

المساهمون: National Institute for Occupational Safety and Health

المصدر: BMJ Open ; volume 11, issue 6, page e045656 ; ISSN 2044-6055 2044-6055

مصطلحات موضوعية: General Medicine

الوصف: Objectives To validate and test the dimensionality of six constructs from the Workplace Integrated Safety and Health (WISH) assessment, an instrument that assesses the extent to which organisations implement integrated systems approaches for protecting and promoting worker health, safety and well-being, in a sample of nursing homes in the USA. Design Validation of an assessment scale using data from a cross-sectional survey. Setting Nursing homes certified by the Centers for Medicaid and Medicare services in three states of the USA: Ohio, California and Massachusetts. Participants 569 directors of nursing from nursing homes serving adults and with more than 30 beds participated in the study. Results Graded response Item Response Theory (IRT) models showed that five out of six constructs were unidimensional based on balanced interpretation of model fit statistics—M2 or C2 with p value >0.05, Comparative Fit Index >0.95, lower bound of the root mean squared error of approximation 90% CI <0.06 and standardised root mean square residual <0.08. Overall measure and construct reliability ranged from acceptable to good. Category boundary location parameters indicated that items were most informative for respondents in lower range of latent scores (ie, β 1 , β 2 , β 3 typically below 0). A few items were recommended to be dropped from future administrations of the instrument based on empirical and substantive interpretation. Conclusions The WISH instrument has utility to understand to what extent organisations integrate protection and promotion of worker health, safety and well-being; however, it is most informative in organisations that present lower scores.

الإتاحة: https://doi.org/10.1136/bmjopen-2020-045656Test

المؤلفون: Sparer, Emily H, Okechukwu, Cassandra A, Manjourides, Justin, Herrick, Robert F, Katz, Jeffrey N, Dennerlein, Jack T

المصدر: Occupational and Environmental Medicine ; volume 71, issue Suppl 1, page A5.2-A5 ; ISSN 1351-0711 1470-7926

مصطلحات موضوعية: Public Health, Environmental and Occupational Health

الإتاحة: https://doi.org/10.1136/oemed-2014-102362.15Test

المؤلفون: Kraus, Virginia Byers, Collins, Jamie E, Hargrove, David, Losina, Elena, Nevitt, Michael, Katz, Jeffrey N, Wang, Susanne X, Sandell, Linda J, Hoffmann, Steven C, Hunter, David J

المصدر: Annals of the Rheumatic Diseases ; volume 76, issue 1, page 186-195 ; ISSN 0003-4967 1468-2060

الوصف: Objective To investigate a targeted set of biochemical biomarkers as predictors of clinically relevant osteoarthritis (OA) progression. Methods Eighteen biomarkers were measured at baseline, 12 months (M) and 24 M in serum (s) and/or urine (u) of cases (n=194) from the OA initiative cohort with knee OA and radiographic and persistent pain worsening from 24 to 48 M and controls (n=406) not meeting both end point criteria. Primary analyses used multivariable regression models to evaluate the association between biomarkers (baseline and time-integrated concentrations (TICs) over 12 and 24 M, transposed to z values) and case status, adjusted for age, sex, body mass index, race, baseline radiographic joint space width, Kellgren-Lawrence grade, pain and pain medication use. For biomarkers with adjusted p<0.1, the c-statistic (area under the curve (AUC)), net reclassification index and the integrated discrimination improvement index were used to further select for hierarchical multivariable discriminative analysis and to determine the most predictive and parsimonious model. Results The 24 M TIC of eight biomarkers significantly predicted case status (ORs per 1 SD change in biomarker): sCTXI 1.28, sHA 1.22, sNTXI 1.25, uC2C-HUSA 1.27, uCTXII, 1.37, uNTXI 1.29, uCTXIα 1.32, uCTXIβ 1.27. 24 M TIC of uCTXII (1.47–1.72) and uC2C-Human Urine Sandwich Assay (HUSA) (1.36–1.50) both predicted individual group status (pain worsening, joint space loss and their combination). The most predictive and parsimonious combinatorial model for case status consisted of 24 M TIC uCTXII, sHA and sNTXI (AUC 0.667 adjusted). Baseline uCTXII and uCTXIα both significantly predicted case status (OR 1.29 and 1.20, respectively). Conclusions Several systemic candidate biomarkers hold promise as predictors of pain and structural worsening of OA.

الإتاحة: https://doi.org/10.1136/annrheumdis-2016-209252Test

المؤلفون: Hunter, David, Nevitt, Michael, Lynch, John, Kraus, Virginia Byers, Katz, Jeffrey N, Collins, Jamie E, Bowes, Mike, Guermazi, Ali, Roemer, Frank W, Losina, Elena

المصدر: Annals of the Rheumatic Diseases ; volume 75, issue 9, page 1607-1614 ; ISSN 0003-4967 1468-2060

الوصف: Objective To perform a longitudinal validation study of imaging bone biomarkers of knee osteoarthritis (OA) progression. Methods We undertook a nested case–control study within the Osteoarthritis Initiative in knees (one knee per subject) with a Kellgren and Lawrence grade of 1–3. Cases were defined as knees having the combination of medial tibiofemoral radiographic progression and pain progression at the 24-month, 36-month or 48-month follow-up compared with baseline. Controls (n=406) were eligible knees that did not meet both endpoint criteria and included 200 with neither radiographic nor pain progression, 103 with radiographic progression only and 103 with pain progression only. Bone surfaces in medial and lateral femur, tibia and patella compartments were segmented from MR images using active appearance models. Independent variables of primary interest included change from baseline to 24 months in (1) total area of bone and (2) position on three-dimensional (3D) bone shape vectors that discriminate OA versus non-OA shapes. We assessed the association of bone markers changes over 24 months with progression using logistic regression. Results 24-month changes in bone area and shape in all compartments were greater in cases than controls, with ORs of being a case per 1 SD increase in bone area ranging from 1.28 to 1.71 across compartments, and per 1 SD greater change in 3D shape vectors ranging from 1.22 to 1.64. Bone markers were associated most strongly with radiographic progression and only weakly with pain progression. Conclusions In knees with mild-to-moderate radiographic OA, changes in bone area and shape over 24 months are associated with the combination of radiographic and pain progression over 48 months. This finding of association with longer term clinical outcome underscores their potential for being an efficacy of intervention biomarker in clinical trials.

الإتاحة: https://doi.org/10.1136/annrheumdis-2015-207602Test