Excessive platelet inhibition following Pipeline embolization of intracranial aneurysms
| العنوان: | Excessive platelet inhibition following Pipeline embolization of intracranial aneurysms |
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| المؤلفون: | Timothy R Miller, Mihir Khunte, Nicholas Caffes, Megan Anders, Peter Rock, Amber L Beitelshees, Ajay Malhotra, Gregory Cannarsa, Jacob Cherian, J Marc Simard, Gaurav Jindal, Dheeraj Gandhi |
| المصدر: | Journal of NeuroInterventional Surgery. :neurintsurg-2022 |
| بيانات النشر: | BMJ, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Surgery, Neurology (clinical), General Medicine |
| الوصف: | BackgroundHigh levels of platelet inhibition have been associated with hemorrhagic complications following Pipeline embolization of intracranial aneurysms. We therefore titrate clopidogrel dosing to maintain a moderate level of platelet inhibition using the VerifyNow P2Y12 assay. However, many patients demonstrate dramatic increases in platelet inhibition following treatment despite being on a consistent antiplatelet regimen. We therefore elected to explore the incidence of this phenomenon and possible predisposing factors.MethodsAll successful Pipeline aneurysm treatments performed at our institution from 2011 to 2019 with moderate procedure-day platelet inhibition levels as indicated by a VerifyNow PRU of 60–235 were included. Patients who received glycoprotein IIb/IIIa inhibitors and those treated for ruptured/symptomatic lesions were excluded. The incidence of excessive platelet inhibition defined by a PRUResultsSome 190 treatments were performed in 178 qualifying patients. A post-procedure PRU ConclusionElevations in platelet inhibition were frequently observed following flow diversion with Pipeline. |
| تدمد: | 1759-8486 1759-8478 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cee5b3292190206516a11e35b2491512Test https://doi.org/10.1136/neurintsurg-2022-018858Test |
| رقم الانضمام: | edsair.doi.dedup.....cee5b3292190206516a11e35b2491512 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17598486 17598478 |
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