In vivo detection of damage in multiple sclerosis cortex and cortical lesions using NODDI
| العنوان: | In vivo detection of damage in multiple sclerosis cortex and cortical lesions using NODDI |
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| المؤلفون: | Andrea Falini, Elisabetta Pagani, Maria A. Rocca, Paolo Preziosa, Laura Cacciaguerra, Raffaello Bonacchi, Massimo Filippi |
| المساهمون: | Preziosa, Paolo, Pagani, Elisabetta, Bonacchi, Raffaello, Cacciaguerra, Laura, Falini, Andrea, Rocca, Maria A, Filippi, Massimo |
| المصدر: | Journal of Neurology, Neurosurgery & Psychiatry. 93:628-636 |
| بيانات النشر: | BMJ, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, Multiple Sclerosis, Neurite, Density reduction, Disease duration, Neuroimaging, multiple sclerosis, Lesion, Multiple Sclerosis, Relapsing-Remitting, Atrophy, In vivo, Internal medicine, Cortex (anatomy), Neurites, medicine, Humans, Cerebral Cortex, business.industry, Multiple sclerosis, medicine.disease, Magnetic Resonance Imaging, Psychiatry and Mental health, Diffusion Magnetic Resonance Imaging, Endocrinology, medicine.anatomical_structure, Surgery, Neurology (clinical), medicine.symptom, business, MRI |
| الوصف: | ObjectiveTo characterise in vivo the microstructural abnormalities of multiple sclerosis (MS) normal-appearing (NA) cortex and cortical lesions (CLs) and their relations with clinical phenotypes and disability using neurite orientation dispersion and density imaging (NODDI).MethodsOne hundred and seventy-two patients with MS (101 relapsing–remitting multiple sclerosis (RRMS), 71 progressive multiple sclerosis (PMS)) and 62 healthy controls (HCs) underwent a brain 3T MRI. Brain cortex and CLs were segmented from three-dimensional T1-weighted and double inversion recovery sequences. Using NODDI on diffusion-weighted sequence, intracellular volume fraction (ICV_f) and Orientation Dispersion Index (ODI) were assessed in NA cortex and CLs with default or optimised parallel diffusivity for the cortex (D//=1.7 or 1.2 µm2/ms, respectively).ResultsThe NA cortex of patients with MS had significantly lower ICV_f versus HCs’ cortex with both D// values (false discovery rate (FDR)-p 2/ms. No CL microstructural differences were found between MS clinical phenotypes. MS NA cortex ICV_f and ODI were significantly correlated with disease duration, clinical disability, lesion burden and global and regional brain atrophy (r from −0.51 to 0.71, FDR-p from ConclusionsA significant neurite loss occurs in MS NA cortex. CLs show a further neurite density reduction and a reduced ODI suggesting a simplification of neurite complexity. NODDI is relevant to investigate in vivo the heterogeneous pathology affecting the MS cortex. |
| تدمد: | 1468-330X 0022-3050 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cc95fd285bc7759d702e5ef07908167Test https://doi.org/10.1136/jnnp-2021-327803Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3cc95fd285bc7759d702e5ef07908167 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1468330X 00223050 |
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