Association between large artery atherosclerosis and cerebral microbleeds: a systematic review and meta-analysis
| العنوان: | Association between large artery atherosclerosis and cerebral microbleeds: a systematic review and meta-analysis |
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| المؤلفون: | Lingling Ding, Bin Peng, Yuehui Hong |
| المصدر: | Stroke and Vascular Neurology |
| بيانات النشر: | BMJ, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, MEDLINE, Disease, 030204 cardiovascular system & hematology, Cochrane Library, Carotid Intima-Media Thickness, Risk Assessment, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, cerebral microbleeds, Internal medicine, medicine, Humans, Carotid Stenosis, intima-media thickness, Aged, Cerebral Hemorrhage, Subclinical infection, arterial stenosis, business.industry, Arterial stenosis, Publication bias, Middle Aged, Atherosclerosis, Prognosis, Surgery, Intima-media thickness, Cerebral Small Vessel Diseases, Meta-analysis, Cardiology, Original Article, Female, Neurology (clinical), Cardiology and Cardiovascular Medicine, business, 030217 neurology & neurosurgery |
| الوصف: | Objective The aim of this systematic review and meta-analysis was to provide evidence that biomarkers of large artery atherosclerosis, including arterial stenosis and greater carotid intima-media thickness (cIMT), may serve as clinical markers of subclinical haemorrhage-prone cerebral small vessel disease, reflected by cerebral microbleeds (CMBs). Methods We searched PubMed, MEDLINE, Web of Science, EMBASE and the Cochrane Library to identify relevant studies published before 1 July 2016. The association between arterial stenosis and CMBs was estimated by the OR and 95% CI. The association of cIMT and CMBs was calculated using the standardised mean difference (SMD). Heterogeneity and publication bias were explored. Results 8 studies including a total of 7160 participants were pooled in the meta-analysis. 6 of the included studies were cross-sectional, except that 2 were prospective. We found a significant association between arterial stenosis >50% and the presence of CMBs (OR 1.95, 95% CI 1.13 to 3.36, I 2 =56.1%). A fixed-effects model suggested that patients with CMBs were more likely to have a greater cIMT (SMD 0.20, 95% CI 0.11 to 0.28, I 2 =24.7%). Conclusions This systematic review and meta-analysis found that there is a relationship between large artery atherosclerosis and CMBs. Future studies are needed to confirm the impact of atherosclerosis on the CMBs, which may have potential therapeutic implications. |
| تدمد: | 2059-8696 2059-8688 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee3d91db54f83e716c342866f746731cTest https://doi.org/10.1136/svn-2016-000049Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ee3d91db54f83e716c342866f746731c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20598696 20598688 |
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