Genomic heterogeneity and efficacy of PI3K pathway inhibitors in patients with gynaecological cancer
| العنوان: | Genomic heterogeneity and efficacy of PI3K pathway inhibitors in patients with gynaecological cancer |
|---|---|
| المؤلفون: | Lorena Fariñas-Madrid, Ana Vivancos, Ana Oaknin, Fiorella Ruiz-Pace, Rodrigo Dienstmann, Guillermo Villacampa, Victor Rodriguez-Freixinos, Ana C. Garrido-Castro, Paolo Nuciforo |
| المساهمون: | Institut Català de la Salut, [Rodriguez-Freixinos V, Fariñas-Madrid L, Oaknin A] Oncologia Mèdica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Gynecological Malignancies Group, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Ruiz-Pace F, Villacampa G] Oncology Data Science - Prescreening Molecular, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Garrido-Castro AC] Oncologia Mèdica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA. [Nuciforo P] Molecular Oncology Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Vivancos A] Cancer Genomics Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Dienstmann R] Oncologia Mèdica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Oncology Data Science - Prescreening Molecular, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain, Hospital Universitari Vall d'Hebron, Vall d'Hebron Barcelona Hospital Campus |
| المصدر: | Scientia Recercat. Dipósit de la Recerca de Catalunya instname ESMO Open, Vol 4, Iss 2 (2019) Recercat: Dipósit de la Recerca de Catalunya Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) ESMO Open |
| بيانات النشر: | BMJ |
| مصطلحات موضوعية: | Oncology, Enzymes and Coenzymes::Enzymes::Transferases::Phosphotransferases::Phosphotransferases (Alcohol Group Acceptor)::Phosphatidylinositol 3-Kinases [CHEMICALS AND DRUGS], Cancer Research, medicine.medical_specialty, neoplasias::neoplasias por localización::neoplasias urogenitales::neoplasias de los genitales femeninos [ENFERMEDADES], Neoplasms::Neoplasms by Site::Urogenital Neoplasms::Genital Neoplasms, Female [DISEASES], Gynaecological cancer, PI3K, lcsh:RC254-282, Internal medicine, Medicine, PTEN, Clinical significance, In patient, PI3K/AKT/mTOR pathway, Otros calificadores::/terapia [Otros calificadores], Original Research, Univariate analysis, biology, business.industry, AKT, Aparell genital femení - Càncer, Other subheadings::/therapy [Other subheadings], lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, enzimas y coenzimas::enzimas::transferasas::fosfotransferasas::fosfotransferasas (grupo alcohol aceptor)::fosfatidil inositol 3 cinasas [COMPUESTOS QUÍMICOS Y DROGAS], Clinical trial, mTOR inhibitors, gynecologic malignancies, mutant allele fraction, Targeted Mutation, Inhibidors enzimàtics, biology.protein, business |
| الوصف: | Malignitats ginecològiques; Fracció al·lel mutant; PI3K Neoplasias ginecológicas; Fracción alélica mutante; PI3K Gynecologic malignancies; Mutant allele fraction; PI3K Objectives Aberrant PI3K/AKT/mTOR activation is common in gynaecological malignancies. However, predictive biomarkers of response to PI3K pathway inhibitors (PAMi) have yet to be identified. Methods We analysed the outcomes of patients with advanced gynaecological cancer with available genomic data, treated with PAMi as single agents or in combination in phase I clinical trials. Clinical relevance of the PIK3CA mutant allele fraction (MAF) was investigated. MAF of each variant was normalised for tumour purity in the sample (adjMAFs) to infer clonality of PIK3CA mutations, defined as clonal (≥0.4) or subclonal ( |
| وصف الملف: | application/pdf |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28b21b8512ac65c2132e1629027164eeTest http://hdl.handle.net/11351/5768Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....28b21b8512ac65c2132e1629027164ee |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |