No distinct microbiome signature of irritable bowel syndrome found in a Swedish random population
| العنوان: | No distinct microbiome signature of irritable bowel syndrome found in a Swedish random population |
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| المؤلفون: | Nicholas J. Talley, Lars Engstrand, Peter T. Schmidt, Lars Agréus, Luisa W. Hugerth, Anna Forsberg, Anna Andreasson, Lars Kjellström |
| المصدر: | Gut. 69:1076-1084 |
| بيانات النشر: | BMJ, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, medicine.medical_specialty, Colonoscopy, Organic disease, Gastroenterology, Irritable Bowel Syndrome, Feces, 03 medical and health sciences, 0302 clinical medicine, RNA, Ribosomal, 16S, Internal medicine, medicine, Humans, Microbiome, Intestinal Mucosa, Irritable bowel syndrome, Sweden, medicine.diagnostic_test, Lachnospiraceae, Middle Aged, medicine.disease, Gastrointestinal Microbiome, 030104 developmental biology, Case-Control Studies, Cohort, 030211 gastroenterology & hepatology, Ruminococcaceae |
| الوصف: | ObjectiveThe ethiopathogenesis of irritable bowel syndrome (IBS) is unknown. While a link to the gut microbiome is postulated, the heterogeneity of the healthy gut makes it difficult to draw definitive conclusions. We aimed to describe the faecal and mucosa-associated microbiome (MAM) and health correlates on a community cohort of healthy and IBS individuals with no colonoscopic findings.DesignThe PopCol study recruited a random sample of 3556 adults; 745 underwent colonoscopy. IBS was defined by Rome IV criteria and organic disease excluded. 16S rRNA gene sequencing was conducted on sigmoid biopsy samples from 376 representative individuals (63 IBS cases) and faecal samples from 185 individuals (32 IBS cases).ResultsWhile sigmoid MAM was dominated by Lachnospiraceae, faeces presented a higher relative abundance of Ruminococcaceae. Microbial richness in MAM was linearly correlated to that in faeces from the same individual (R²=0.255, pCoprococcus catus associated with lower levels of depression (r=−0.003, p=0.00017). The degree of heterogeneity observed between IBS patients is higher than that observed between healthy individuals.ConclusionsNo distinct microbial signature was observed in IBS. Individuals presenting with low self-rated health or high BMI have lower gut microbiome richness. |
| تدمد: | 1468-3288 0017-5749 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52252c5db06bdf410381d53dc48cd62cTest https://doi.org/10.1136/gutjnl-2019-318717Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....52252c5db06bdf410381d53dc48cd62c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14683288 00175749 |
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