Agomelatine rescues lipopolysaccharide-induced neural injury and depression-like behaviors via suppression of the Gαi-2-PKA-ASK1 signaling pathway

التفاصيل البيبلوغرافية
العنوان:	Agomelatine rescues lipopolysaccharide-induced neural injury and depression-like behaviors via suppression of the Gαi-2-PKA-ASK1 signaling pathway
المؤلفون:	Tian Lan, Yuhan Wu, Yulei Zhang, Shuhan Li, Zhanpeng Zhu, Liyan Wang, Xueqin Mao, Ye Li, Cuiqin Fan, Wenjing Wang, Shu Yan Yu
المصدر:	Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-14 (2022)
بيانات النشر:	BMC, 2022.
سنة النشر:	2022
المجموعة:	LCC:Neurology. Diseases of the nervous system
مصطلحات موضوعية:	Agomelatine, 5-HT2C receptor, Gαi-2, Apoptosis, Depression, Neurology. Diseases of the nervous system, RC346-429
الوصف:	Highlights 1. Agomelatine ameliorated anxiety and depression-like behaviors in rats. 2. Agomelatine regulated LPS-induced neuroinflammation and neuronal apoptosis. 3. Agomelatine decreased the enhanced autophagy and synaptic damage in LPS-treated rats. 4. Agomelatine alleviated neural injury via suppression of Gαi-2-PKA-ASK1 pathway.
نوع الوثيقة:	article
وصف الملف:	electronic resource
اللغة:	English
تدمد:	1742-2094
العلاقة:	https://doaj.org/toc/1742-2094Test
DOI:	10.1186/s12974-022-02479-x
الوصول الحر:	https://doaj.org/article/078764e7e37e4dc0a87853168890bdcbTest
رقم الانضمام:	edsdoj.078764e7e37e4dc0a87853168890bdcb
قاعدة البيانات:	Directory of Open Access Journals

الوصف
تدمد:	17422094
DOI:	10.1186/s12974-022-02479-x