دورية أكاديمية
Animal models of migraine and experimental techniques used to examine trigeminal sensory processing
| العنوان: | Animal models of migraine and experimental techniques used to examine trigeminal sensory processing |
|---|---|
| المؤلفون: | Harriott, Andrea M., Strother, Lauren C., Vila-Pueyo, Marta, Holland, Philip R. |
| المصدر: | Harriott , A M , Strother , L C , Vila-Pueyo , M & Holland , P R 2019 , ' Animal models of migraine and experimental techniques used to examine trigeminal sensory processing ' , Journal of Headache and Pain , vol. 20 , no. 1 , 91 . https://doi.org/10.1186/s10194-019-1043-7Test |
| بيانات النشر: | BMC Springer Milan |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Animal models, Electrophysiology, Headache, Migraine, Pain, Preclinical, Translation |
| الوصف: | Background: Migraine is a common debilitating condition whose main attributes are severe recurrent headaches with accompanying sensitivity to light and sound, nausea and vomiting. Migraine-related pain is a major cause of its accompanying disability and can encumber almost every aspect of daily life. Main body: Advancements in our understanding of the neurobiology of migraine headache have come in large from basic science research utilizing small animal models of migraine-related pain. In this current review, we aim to describe several commonly utilized preclinical models of migraine. We will discuss the diverse array of methodologies for triggering and measuring migraine-related pain phenotypes and highlight briefly specific advantages and limitations therein. Finally, we will address potential future challenges/opportunities to refine existing and develop novel preclinical models of migraine that move beyond migraine-related pain and expand into alternate migraine-related phenotypes. Conclusion: Several well validated animal models of pain relevant for headache exist, the researcher should consider the advantages and limitations of each model before selecting the most appropriate to answer the specific research question. Further, we should continually strive to refine existing and generate new animal and non-animal models that have the ability to advance our understanding of head pain as well as non-pain symptoms of primary headache disorders. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://kclpure.kcl.ac.uk/ws/files/119346967/Animal_models_of_migraine_HARRIOTT_Accepted19August2019Publishedonline29August2019_GOLD_VoR_CC_BY_.pdfTest; https://kclpure.kcl.ac.uk/portal/en/publications/animal-models-of-migraine-and-experimental-techniques-used-to-examine-trigeminal-sensory-processingTest(7014310f-bb8f-4505-994a-1009f5b77f52).html |
| الإتاحة: | https://doi.org/10.1186/s10194-019-1043-7Test https://kclpure.kcl.ac.uk/ws/files/119346967/Animal_models_of_migraine_HARRIOTT_Accepted19August2019Publishedonline29August2019_GOLD_VoR_CC_BY_.pdfTest https://kclpure.kcl.ac.uk/portal/en/publications/animal-models-of-migraine-and-experimental-techniques-used-to-examine-trigeminal-sensory-processingTest(7014310f-bb8f-4505-994a-1009f5b77f52).html |
| حقوق: | undefined |
| رقم الانضمام: | edsbas.BDA5767D |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |