دورية أكاديمية
Carotid intimal-media thickness as a surrogate for cardiovascular disease events in trials of HMG-CoA reductase inhibitors
| العنوان: | Carotid intimal-media thickness as a surrogate for cardiovascular disease events in trials of HMG-CoA reductase inhibitors |
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| المؤلفون: | Morgan Timothy, Terry James G, O'Leary Daniel H, Espeland Mark A, Evans Greg, Mudra Harald |
| المصدر: | Current Controlled Trials in Cardiovascular Medicine, Vol 6, Iss 1, p 3 (2005) |
| بيانات النشر: | BMC |
| سنة النشر: | 2005 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Arteriosclerosis, carotid arteries, drugs, meta-analysis, statistics, ultrasonics, Medicine (General), R5-920 |
| الوصف: | Background Surrogate measures for cardiovascular disease events have the potential to increase greatly the efficiency of clinical trials. A leading candidate for such a surrogate is the progression of intima-media thickness (IMT) of the carotid artery; much experience has been gained with this endpoint in trials of HMG-CoA reductase inhibitors (statins). Methods and Results We examine two separate systems of criteria that have been proposed to define surrogate endpoints, based on clinical and statistical arguments. We use published results and a formal meta-analysis to evaluate whether progression of carotid IMT meets these criteria for HMG-CoA reductase inhibitors (statins). IMT meets clinical-based criteria to serve as a surrogate endpoint for cardiovascular events in statin trials, based on relative efficiency, linkage to endpoints, and congruency of effects. Results from a meta-analysis and post-trial follow-up from a single published study suggest that IMT meets established statistical criteria by accounting for intervention effects in regression models. Conclusion Carotid IMT progression meets accepted definitions of a surrogate for cardiovascular disease endpoints in statin trials. This does not, however, establish that it may serve universally as a surrogate marker in trials of other agents. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1468-6708 |
| العلاقة: | http://cvm.controlled-trials.com/content/6/1/3Test; https://doaj.org/toc/1468-6708Test; https://doaj.org/article/4a9178f25f6147958672786cf4900679Test |
| DOI: | 10.1186/1468-6708-6-3 |
| الإتاحة: | https://doi.org/10.1186/1468-6708-6-3Test https://doaj.org/article/4a9178f25f6147958672786cf4900679Test |
| رقم الانضمام: | edsbas.926FE444 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14686708 |
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| DOI: | 10.1186/1468-6708-6-3 |