دورية أكاديمية
Effects of dexrazoxane on doxorubicin-related cardiotoxicity and second malignant neoplasms in children with osteosarcoma: a report from the Children’s Oncology Group
| العنوان: | Effects of dexrazoxane on doxorubicin-related cardiotoxicity and second malignant neoplasms in children with osteosarcoma: a report from the Children’s Oncology Group |
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| المؤلفون: | Lisa M. Kopp, Richard B. Womer, Cindy L. Schwartz, David H. Ebb, Vivian I. Franco, David Hall, Donald A. Barkauskas, Mark D. Krailo, Holcombe E. Grier, Paul A. Meyers, Leonard H. Wexler, Neyssa M. Marina, Katherine A. Janeway, Richard Gorlick, Mark L. Bernstein, Steven E. Lipshultz, for the Children’s Oncology Group |
| المصدر: | Cardio-Oncology, Vol 5, Iss 1, Pp 1-12 (2019) |
| بيانات النشر: | BMC, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Diseases of the circulatory (Cardiovascular) system LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | Osteosarcoma, Pediatrics, Cardiotoxicity, Doxorubicin, Diseases of the circulatory (Cardiovascular) system, RC666-701, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Abstract Background Dexrazoxane protects from lower-cumulative-dose doxorubicin cardiotoxicity, but the effect of dexrazoxane in children with sarcoma treated with higher-cumulative-dose doxorubicin is unknown. Methods We evaluated children with osteosarcoma (OS) on two Children’s Oncology Group trials with higher dose doxorubicin (375–600 mg/m2) preceded by dexrazoxane (10:1 dexrazoxane:doxorubicin dosing). They were evaluated after the minimum expected treatment time (METT), defined as 28 weeks. Cardiotoxicity was identified by echocardiography and serum N-terminal pro-brain natriuretic peptide (NT-proBNP). Second malignant neoplasm (SMN) data was collected. Results All children had normal left ventricular (LV) systolic function as measured by LV fractional shortening and no heart failure. The end-diastolic septal thickness Z-scores (P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2057-3804 |
| العلاقة: | http://link.springer.com/article/10.1186/s40959-019-0050-9Test; https://doaj.org/toc/2057-3804Test |
| DOI: | 10.1186/s40959-019-0050-9 |
| الوصول الحر: | https://doaj.org/article/c1df26e926ca40859f1f7499883d65cdTest |
| رقم الانضمام: | edsdoj.1df26e926ca40859f1f7499883d65cd |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20573804 |
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| DOI: | 10.1186/s40959-019-0050-9 |