دورية أكاديمية
The Intensive Diet and Exercise for Arthritis (IDEA) trial: design and rationale
| العنوان: | The Intensive Diet and Exercise for Arthritis (IDEA) trial: design and rationale |
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| المؤلفون: | Eckstein Felix, Lyles Mary, DeVita Paul, Loeser Richard F, Miller Gary D, Mihalko Shannon, Legault Claudine, Messier Stephen P, Hunter David J, Williamson Jeff D, Nicklas Barbara J |
| المصدر: | BMC Musculoskeletal Disorders, Vol 10, Iss 1, p 93 (2009) |
| بيانات النشر: | BMC |
| سنة النشر: | 2009 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Diseases of the musculoskeletal system, RC925-935 |
| الوصف: | Background Obesity is the most modifiable risk factor, and dietary induced weight loss potentially the best nonpharmacologic intervention to prevent or to slow osteoarthritis (OA) disease progression. We are currently conducting a study to test the hypothesis that intensive weight loss will reduce inflammation and joint loads sufficiently to alter disease progression, either with or without exercise. This article describes the intervention, the empirical evidence to support it, and test-retest reliability data. Methods/Design This is a prospective, single-blind, randomized controlled trial. The study population consists of 450 overweight and obese (BMI = 27–40.5 kg/m 2 ) older (age ≥ 55 yrs) adults with tibiofemoral osteoarthritis. Participants are randomized to one of three 18-month interventions: intensive dietary restriction-plus-exercise; exercise-only; or intensive dietary restriction-only. The primary aims are to compare the effects of these interventions on inflammatory biomarkers and knee joint loads. Secondary aims will examine the effects of these interventions on function, pain, and mobility; the dose response to weight loss on disease progression; if inflammatory biomarkers and knee joint loads are mediators of the interventions; and the association between quadriceps strength and disease progression. Results Test-retest reliability results indicated that the ICCs for knee joint load variables were excellent, ranging from 0.86 – 0.98. Knee flexion/extension moments were most affected by BMI, with lower reliability with the highest tertile of BMI. The reliability of the semi-quantitative scoring of the knee joint using MRI exceeded previously reported results, ranging from a low of 0.66 for synovitis to a high of 0.99 for bone marrow lesion size. Discussion The IDEA trial has the potential to enhance our understanding of the OA disease process, refine weight loss and exercise recommendations in this prevalent disease, and reduce the burden of disability. Trial Registration NCT00381290 |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1471-2474 |
| العلاقة: | http://www.biomedcentral.com/1471-2474/10/93Test; https://doaj.org/toc/1471-2474Test; https://doaj.org/article/14bd5af432fb4114b1e71c2c6ce7291fTest |
| DOI: | 10.1186/1471-2474-10-93 |
| الإتاحة: | https://doi.org/10.1186/1471-2474-10-93Test https://doaj.org/article/14bd5af432fb4114b1e71c2c6ce7291fTest |
| رقم الانضمام: | edsbas.87F9DBC7 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14712474 |
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| DOI: | 10.1186/1471-2474-10-93 |