دورية أكاديمية
Association between the 21-gene recurrence score and isolated locoregional recurrence in stage I-II, hormone receptor-positive breast cancer
| العنوان: | Association between the 21-gene recurrence score and isolated locoregional recurrence in stage I-II, hormone receptor-positive breast cancer |
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| المؤلفون: | David D. Yang, Daniela L. Buscariollo, Angel M. Cronin, Shicheng Weng, Melissa E. Hughes, Richard J. Bleicher, Adam L. Cohen, Sara H. Javid, Stephen B. Edge, Beverly Moy, Joyce C. Niland, Antonio C. Wolff, Michael J. Hassett, Rinaa S. Punglia |
| المصدر: | Radiation Oncology, Vol 15, Iss 1, Pp 1-7 (2020) |
| بيانات النشر: | BMC, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Medical physics. Medical radiology. Nuclear medicine LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | Breast cancer, Locoregional recurrence, Recurrence score, Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Abstract Background Although the 21-gene recurrence score (RS) assay is widely used to predict distant recurrence risk and benefit from adjuvant chemotherapy among women with hormone receptor-positive (HR+) breast cancer, the relationship between the RS and isolated locoregional recurrence (iLRR) remains poorly understood. Therefore, we examined the association between the RS and risk of iLRR for women with stage I-II, HR+ breast cancer. Methods We identified 1758 women captured in the national prospective Breast Cancer-Collaborative Outcomes Research Database who were diagnosed with stage I-II, HR+ breast cancer from 2006 to 2012, treated with mastectomy or breast-conserving surgery, and received RS testing. Women who received neoadjuvant therapy were excluded. The association between the RS and risk of iLRR was examined using competing risks regression. Results Overall, 19% of the cohort (n = 329) had a RS ≥25. At median follow-up of 29 months, only 22 iLRR events were observed. Having a RS ≥25 was not associated with a significantly higher risk of iLRR compared to a RS |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1748-717X |
| العلاقة: | http://link.springer.com/article/10.1186/s13014-020-01640-1Test; https://doaj.org/toc/1748-717XTest |
| DOI: | 10.1186/s13014-020-01640-1 |
| الوصول الحر: | https://doaj.org/article/d4bb13507ca44041af2782a5fdc08c31Test |
| رقم الانضمام: | edsdoj.4bb13507ca44041af2782a5fdc08c31 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 1748717X |
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| DOI: | 10.1186/s13014-020-01640-1 |