دورية أكاديمية
Survival of adult neurons lacking cholesterol synthesis in vivo
| العنوان: | Survival of adult neurons lacking cholesterol synthesis in vivo |
|---|---|
| المؤلفون: | Möbius Wiebke, Xiao Le, Saher Gesine, Fünfschilling Ursula, Nave Klaus-Armin |
| المصدر: | BMC Neuroscience, Vol 8, Iss 1, p 1 (2007) |
| بيانات النشر: | BMC |
| سنة النشر: | 2007 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurophysiology and neuropsychology, QP351-495 |
| الوصف: | Background Cholesterol, an essential component of all mammalian plasma membranes, is highly enriched in the brain. Both during development and in the adult, brain cholesterol is derived from local cholesterol synthesis and not taken up from the circulation. However, the contribution of neurons and glial cells to total brain cholesterol metabolism is unknown. Results Using conditional gene inactivation in the mouse, we disrupted the squalene synthase gene ( fdft1 ), which is critical for cholesterol synthesis, in cerebellar granule cells and some precerebellar nuclei. Mutant mice showed no histological signs of neuronal degeneration, displayed ultrastructurally normal synapses, and exhibited normal motor coordination. This revealed that these adult neurons do not require cell-autonomous cholesterol synthesis for survival or function. Conclusion We conclude that at least some adult neurons no longer require endogenous cholesterol synthesis and can fully meet their cholesterol needs by uptake from their surrounding. Glia are a likely source of cholesterol in the central nervous system. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1471-2202 |
| العلاقة: | http://www.biomedcentral.com/1471-2202/8/1Test; https://doaj.org/toc/1471-2202Test; https://doaj.org/article/2dd5a61e148547a6962c55a7eb33683fTest |
| DOI: | 10.1186/1471-2202-8-1 |
| الإتاحة: | https://doi.org/10.1186/1471-2202-8-1Test https://doaj.org/article/2dd5a61e148547a6962c55a7eb33683fTest |
| رقم الانضمام: | edsbas.E9C3039 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14712202 |
|---|---|
| DOI: | 10.1186/1471-2202-8-1 |