Influenza A H5N1 and HIV co-infection: case report
| العنوان: | Influenza A H5N1 and HIV co-infection: case report |
|---|---|
| المؤلفون: | Annette Fox, Peter Horby, Nguyen Hong Ha, Heiman F. L. Wertheim, Nguyen Tien Lam, Nguyen Van Kinh, Le Nguyen Minh Hoa, Cameron P. Simmons, Jeremy Farrar |
| المصدر: | BMC Infectious Diseases, Vol 10, Iss 1, p 167 (2010) BMC Infectious Diseases |
| بيانات النشر: | BMC, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Adult, Male, Oseltamivir, Secondary infection, Case Report, HIV Infections, CD8-Positive T-Lymphocytes, HIV Antibodies, Biology, medicine.disease_cause, Antiviral Agents, Tachypnea, Virus, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, chemistry.chemical_compound, Fatal Outcome, 0302 clinical medicine, CD28 Antigens, Immunity, Influenza, Human, medicine, Humans, Cytotoxic T cell, lcsh:RC109-216, 030212 general & internal medicine, 030304 developmental biology, 0303 health sciences, Influenza A Virus, H5N1 Subtype, virus diseases, Acquired immune system, Virology, Influenza A virus subtype H5N1, Anti-Bacterial Agents, CD4 Lymphocyte Count, Tumor Necrosis Factor Receptor Superfamily, Member 7, 3. Good health, Infectious Diseases, chemistry, Immunology, Cytokines, medicine.symptom |
| الوصف: | Background The role of adaptive immunity in severe influenza is poorly understood. The occurrence of influenza A/H5N1 in a patient with HIV provided a rare opportunity to investigate this. Case Presentation A 30-year-old male was admitted on day 4 of influenza-like-illness with tachycardia, tachypnea, hypoxemia and bilateral pulmonary infiltrates. Influenza A/H5N1 and HIV tests were positive and the patient was treated with Oseltamivir and broad-spectrum antibiotics. Initially his condition improved coinciding with virus clearance by day 6. He clinically deteriorated as of day 10 with fever recrudescence and increasing neutrophil counts and died on day 16. His admission CD4 count was 100/μl and decreased until virus was cleared. CD8 T cells shifted to a CD27+CD28- phenotype. Plasma chemokine and cytokine levels were similar to those found previously in fatal H5N1. Conclusions The course of H5N1 infection was not notably different from other cases. Virus was cleared despite profound CD4 T cell depletion and aberrant CD8 T cell activation but this may have increased susceptibility to a fatal secondary infection. |
| اللغة: | English |
| تدمد: | 1471-2334 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02a8e63837150e43377cbedb84606cfbTest http://www.biomedcentral.com/1471-2334/10/167Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....02a8e63837150e43377cbedb84606cfb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14712334 |
|---|