دورية أكاديمية
أعرض في EDS

Plasma contact factors as novel biomarkers for diagnosing Alzheimer’s disease

التفاصيل البيبلوغرافية
العنوان: Plasma contact factors as novel biomarkers for diagnosing Alzheimer’s disease
المؤلفون: Jung Eun Park, Do Sung Lim, Yeong Hee Cho, Kyu Yeong Choi, Jang Jae Lee, Byeong C. Kim, Kun Ho Lee, Jung Sup Lee
المصدر: Biomarker Research, Vol 9, Iss 1, Pp 1-8 (2021)
بيانات النشر: BMC, 2021.
سنة النشر: 2021
المجموعة: LCC:Therapeutics. Pharmacology
مصطلحات موضوعية: Alzheimer’s disease, Biomarkers, Contact factor, FXIIa, Plasma, Therapeutics. Pharmacology, RM1-950
الوصف: Abstract Background Alzheimer’s disease (AD) is the most common cause of dementia and most of AD patients suffer from vascular abnormalities and neuroinflammation. There is an urgent need to develop novel blood biomarkers capable of diagnosing Alzheimer’s disease (AD) at very early stage. This study was performed to find out new accurate plasma diagnostic biomarkers for AD by investigating a direct relationship between plasma contact system and AD. Methods A total 101 of human CSF and plasma samples from normal and AD patients were analyzed. The contact factor activities in plasma were measured with the corresponding specific peptide substrates. Results The activities of contact factors (FXIIa, FXIa, plasma kallikrein) and FXa clearly increased and statistically correlated as AD progresses. We present here, for the first time, the FXIIa cut-off scores to as: > 26.3 U/ml for prodromal AD [area under the curve (AUC) = 0.783, p 27.2 U/ml for AD dementia (AUC = 0.906, p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2050-7771
42740584
العلاقة: https://doaj.org/toc/2050-7771Test
DOI: 10.1186/s40364-020-00258-5
الوصول الحر: https://doaj.org/article/2728c42740584f1f8d6a75bf1bdccb9dTest
رقم الانضمام: edsdoj.2728c42740584f1f8d6a75bf1bdccb9d
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20507771
42740584
DOI:10.1186/s40364-020-00258-5