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Health-related quality of life in men with localized prostate cancer treated with radiotherapy: validation of an abbreviated version of the Expanded Prostate Cancer Index Composite for Clinical Practice in Spain

التفاصيل البيبلوغرافية
العنوان: Health-related quality of life in men with localized prostate cancer treated with radiotherapy: validation of an abbreviated version of the Expanded Prostate Cancer Index Composite for Clinical Practice in Spain
المؤلفون: Zapatero, Almudena, Maldonado Pijoan, Javier, Gómez‑Caamaño, Antonio, Pardo Masferrer, José, Macías Hernández, Víctor, Hervás Morón, Asunción
المساهمون: Institut Català de la Salut, Zapatero A Department of Radiation Oncology, Hospital Universitario de La Princesa, Madrid, Spain. Maldonado Pijoan X Servei d’Oncologia Radioteràpica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Gómez-Caamaño A Department of Radiation Oncology, Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, A Coruña, Spain. Pardo Masferrer J Department of Radiation Oncology, Hospital Universitari Son Espases, Palma de Mallorca, Spain. Macías Hernández V Hospital Universitario Y Politecnico La Fe, Valencia, Spain. Hervás Morón A Department of Radiation Oncology, Hospital Ramon Y Cajal, Madrid, Spain, Vall d'Hebron Barcelona Hospital Campus
المصدر: Scientia
بيانات النشر: BMC
سنة النشر: 2021
مصطلحات موضوعية: Pròstata - Càncer - Radioteràpia, Qüestionaris, Avaluació de resultats (Assistència sanitària), DISEASES::Neoplasms::Neoplasms by Site::Urogenital Neoplasms::Genital Neoplasms, Male::Prostatic Neoplasms, Other subheadings::Other subheadings::Other subheadings::/radiotherapy, ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Investigative Techniques::Epidemiologic Methods::Epidemiologic Research Design::Reproducibility of Results, AND EQUIPMENT::Investigative Techniques::Epidemiologic Methods::Data Collection::Surveys and Questionnaires, ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias urogenitales::neoplasias de los genitales masculinos::neoplasias de la próstata, Otros calificadores::Otros calificadores::Otros calificadores::/radioterapia, TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::métodos epidemiológicos::diseño de la investigación epidemiológica::reproducibilidad de los resultados, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::métodos epidemiológicos::recopilación de datos::encuestas y cuestionarios
الوصف: Cáncer de próstata; Evaluación de la calidad de vida; Radioterapia ; Càncer de pròstata; Avaluació de la qualitat de vida; Radioteràpia ; Prostate cancer; Quality-of-life assessment; Radiotherapy ; Background Health-related quality of life (HRQoL) is greatly affected by prostate cancer (PCa) and associated treatments. This study aimed to measure the impact of radiotherapy on HRQoL and to further validate the Spanish version of the 16-item Expanded Prostate Cancer Index Composite (EPIC-16) in routine clinical practice. Methods An observational, non-interventional, multicenter study was conducted in Spain with localized PCa patients initiating treatment with external beam radiotherapy (EBRT) or brachytherapy (BQT). Changes from baseline in EPIC-16, University of California-Los Angeles Prostate Cancer Index (UCLA-PCI), and patient-perceived health status were longitudinally assessed at end of radiotherapy (V2) and 90 days thereafter (V3). Psychometric evaluations of the Spanish EPIC-16 were conducted. Results Of 516 patients enrolled, 495 were included in the analysis (EBRT, n = 361; BQT, n = 134). At baseline, mean (standard deviation [SD]) EPIC-16 global scores were 11.9 (7.5) and 10.3 (7.7) for EBRT and BQT patients, respectively; scores increased, i.e., HRQoL worsened, from baseline, by mean (SD) of 6.8 (7.6) at V2 and 2.4 (7.4) at V3 for EBRT and 4.2 (7.6) and 3.9 (8.2) for BQT patients. Changes in Spanish EPIC-16 domains correlated well with urinary, bowel, and sexual UCLA-PCI domains. EPIC-16 showed good internal consistency (Cronbach’s alpha = .84), reliability, and construct validity. Conclusion The Spanish EPIC-16 questionnaire demonstrated sensitivity, strong discriminative properties and reliability, and validity for use in clinical practice. EPIC-16 scores worsened after radiotherapy in different HRQoL domains; however, a strong tendency towards recovery was seen at the 3-month follow-up visit. ; This study was funded by Astellas Pharma Inc.
نوع الوثيقة: article in journal/newspaper
وصف الملف: application/pdf
اللغة: English
تدمد: 1477-7525
العلاقة: Health and Quality of Life Outcomes;19; https://doi.org/10.1186/s12955-021-01856-zTest; Zapatero A, Maldonado Pijoan X, Gómez-Caamaño A, Pardo Masferrer J, Macías Hernández V, Hervás Morón A, et al. Health-related quality of life in men with localized prostate cancer treated with radiotherapy: validation of an abbreviated version of the Expanded Prostate Cancer Index Composite for Clinical Practice in Spain. Health Qual Life Outcomes. 2021 Sep 25;19:223.; https://hdl.handle.net/11351/7394Test; 000699023500002
DOI: 10.1186/s12955-021-01856-z
الإتاحة: https://doi.org/10.1186/s12955-021-01856-zTest
https://hdl.handle.net/11351/7394Test
حقوق: Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0Test/ ; info:eu-repo/semantics/openAccess
رقم الانضمام: edsbas.263242DC
قاعدة البيانات: BASE
الوصف
تدمد:14777525
DOI:10.1186/s12955-021-01856-z