Frozen section accurately allows pathological characterization of endometrial cancer in patients with a preoperative ambiguous or inconclusive diagnoses: our experience
| العنوان: | Frozen section accurately allows pathological characterization of endometrial cancer in patients with a preoperative ambiguous or inconclusive diagnoses: our experience |
|---|---|
| المؤلفون: | Angela Santoro, Saveria Spadola, Gianfranco Zannoni, Giovanni Scambia, Maurizio Martini, Valerio Gallotta, Anna Fagotti, Frediano Inzani, Alessia Piermattei, Damiano Arciuolo, Michele Valente, Giuseppe Angelico, Francesco Fanfani |
| المصدر: | BMC Cancer, Vol 19, Iss 1, Pp 1-8 (2019) BMC Cancer |
| بيانات النشر: | BMC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Cancer Research, medicine.medical_specialty, Frozen section, Biopsy, Endometrial carcinoma, Intraoperative surgical staging, lcsh:RC254-282, 03 medical and health sciences, 0302 clinical medicine, Surgical oncology, Preoperative Care, Genetics, Carcinoma, Medicine, Frozen Sections, Humans, Neoplasm Invasiveness, Medical diagnosis, Neoplasm Metastasis, Pathological, Grading (tumors), Neoplasm Staging, Retrospective Studies, Frozen section procedure, 030219 obstetrics & reproductive medicine, Intraoperative Care, business.industry, Endometrial cancer, Retrospective cohort study, medicine.disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Magnetic Resonance Imaging, Endometrial Neoplasms, Settore MED/40 - GINECOLOGIA E OSTETRICIA, Oncology, 030220 oncology & carcinogenesis, Female, Neoplasm Grading, Radiology, business, Research Article |
| الوصف: | Background The aim of this study was to assess the agreement rate between intraoperative evaluation (IOE) and final diagnosis (FD) in a series of surgically resected endometrial carcinoma (EC), with a preoperative ambiguous or inconclusive diagnosis by endometrial biopsies and imaging. Methods A retrospective study was performed selecting patients who underwent surgery with IOE for suspected EC at our institution from 2012 to 2018. A K coefficient was determined with respect to the histotype, tumor grade, myometrial infiltration and cervical involvement. Results Data analysis has been performed on 202 women. The IOE evaluation was distributed as Endometrioid (n = 180) and Non-Endometrioid (n = 22). The comparison between the frozen section (FS) and the definitive histological subtype showed an overall agreement rate of 93,07% (k = 0.612) and an agreement of 97.2% for Endometrioid vs 59% for Non-Endometrioid tumors. The FIGO system grading was the same in 91,1% of patients, none was upgraded and in 8,9% downgraded. Observed agreements were 89,11% and 95,54% for myometrial and cervical involvement, respectively. Conclusions The good agreement between intraoperative grading, myometrial invasion and their histological definition on permanent sections highlights that FS is a good predictor for surgical outcome, in particular in presence of a preoperative ambiguous or inconclusive diagnostic evaluation. |
| اللغة: | English |
| تدمد: | 1471-2407 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::239b202cb3fe78b9de0e6b91ae3d04efTest http://link.springer.com/article/10.1186/s12885-019-6318-5Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....239b202cb3fe78b9de0e6b91ae3d04ef |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14712407 |
|---|