دورية أكاديمية
H3K18 lactylation marks tissue‑specific active enhancers
| العنوان: | H3K18 lactylation marks tissue‑specific active enhancers |
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| المؤلفون: | Galle, Eva, Ruiz Ojeda, Francisco Javier, Ruiz Ruiz, Jonatan |
| بيانات النشر: | BMC |
| سنة النشر: | 2022 |
| المجموعة: | DIGIBUG: Repositorio Institucional de la Universidad de Granada |
| مصطلحات موضوعية: | Lactylation, H3K18la, Lactate, Epigenetics, Embryonic stem cell, Macrophage, Adipocyte, CUT&Tag, ChromHMM, Histone post-translational modification, Promoter, Enhancer |
| الوصف: | Background: Histone lactylation has been recently described as a novel histone posttranslational modification linking cellular metabolism to epigenetic regulation. Results: Given the expected relevance of this modification and current limited knowledge of its function, we generate genome-wide datasets of H3K18la distribution in various in vitro and in vivo samples, including mouse embryonic stem cells, macrophages, adipocytes, and mouse and human skeletal muscle. We compare them to profiles of well-established histone modifications and gene expression patterns. Supervised and unsupervised bioinformatics analysis shows that global H3K18la distribution resembles H3K27ac, although we also find notable differences. H3K18la marks active CpG islandcontaining promoters of highly expressed genes across most tissues assessed, including many housekeeping genes, and positively correlates with H3K27ac and H3K4me3 as well as with gene expression. In addition, H3K18la is enriched at active enhancers that lie in proximity to genes that are functionally important for the respective tissue. Conclusions: Overall, our data suggests that H3K18la is not only a marker for active promoters, but also a mark of tissue specific active enhancers. ; ETH Zurich ETH Zurich core funding ; European Research Council (ERC) European Commission 803491 ; Botnar Research Centre for Child Health Multi-Investigator Project ; World Food System Center of ETH Zurich ; Integrative Food and Nutrition Center of EPFL |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | Galle, E. [et al.]. H3K18 lactylation marks tissue-specific active enhancers. Genome Biol 23, 207 (2022). [https://doi.org/10.1186/s13059-022-02775-yTest]; https://hdl.handle.net/10481/77753Test |
| DOI: | 10.1186/s13059-022-02775-y |
| الإتاحة: | https://doi.org/10.1186/s13059-022-02775-yTest https://hdl.handle.net/10481/77753Test |
| حقوق: | Atribución 4.0 Internacional ; http://creativecommons.org/licenses/by/4.0Test/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.330590F7 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s13059-022-02775-y |
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