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Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude

التفاصيل البيبلوغرافية
العنوان: Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude
المؤلفون: Kadalayil, L, Alam, MZ, White, CH, Ghantous, A, Walton, E, Gruzieva, O, Merid, SK, Kumar, A, Roy, RP, Solomon, O, Huen, K, Eskenazi, B, Rzehak, P, Grote, V, Langhendries, J-P, Verduci, E, Ferre, N, Gruszfeld, D, Gao, L, Guan, W, Zeng, X, Schisterman, EF, Dou, JF, Bakulski, KM, Feinberg, JI, Soomro, MH, Pesce, G, Baiz, N, Isaevska, E, Plusquin, M, Vafeiadi, M, Roumeliotaki, T, Langie, SAS, Standaert, A, Allard, C, Perron, P, Bouchard, L, van Meel, ER, Felix, JF, Jaddoe, VWV, Yousefi, PD, Ramlau-Hansen, CH, Relton, CL, Tobi, EW, Starling, AP, Yang, IV, Llambrich, M, Santorelli, G, Lepeule, J, Salas, LA, Bustamante, M, Ewart, SL, Zhang, H, Karmaus, W, Röder, S, Zenclussen, AC, Jin, J, Nystad, W, Page, CM, Magnus, M, Jima, DD, Hoyo, C, Maguire, RL, Kvist, T, Czamara, D, Räikkönen, K, Gong, T, Ullemar, V, Rifas-Shiman, SL, Oken, E, Almqvist, C, Karlsson, R, Lahti, J, Murphy, SK, Håberg, SE, London, S, Herberth, G, Arshad, H, Sunyer, J, Grazuleviciene, R, Dabelea, D, Steegers-Theunissen, RPM, Nohr, EA, Sørensen, TIA, Duijts, L, Hivert, M-F, Nelen, V, Popovic, M, Kogevinas, M, Nawrot, TS, Herceg, Z, Annesi-Maesano, I, Fallin, MD, Yeung, E, Breton, CV, Koletzko, B, Holland, N, Wiemels, JL, Melén, E, Sharp, GC, Silver, MJ, Rezwan, FI, Holloway, JW
بيانات النشر: BMC
سنة النشر: 2023
المجموعة: University of Exeter: Open Research Exeter (ORE)
مصطلحات موضوعية: Birth season, DNA methylation, Differentially methylated regions (DMR), Latitude, Meta-analysis, PACE
الوصف: This is the final version. Available from BMC via the DOI in this record. ; Individual cohort-level data can be obtained from the respective cohort (see Additional file 1: Table S1 and Additional file 2 for cohort details). ; BACKGROUND: Seasonal variations in environmental exposures at birth or during gestation are associated with numerous adult traits and health outcomes later in life. Whether DNA methylation (DNAm) plays a role in the molecular mechanisms underlying the associations between birth season and lifelong phenotypes remains unclear. METHODS: We carried out epigenome-wide meta-analyses within the Pregnancy And Childhood Epigenetic Consortium to identify associations of DNAm with birth season, both at differentially methylated probes (DMPs) and regions (DMRs). Associations were examined at two time points: at birth (21 cohorts, N = 9358) and in children aged 1-11 years (12 cohorts, N = 3610). We conducted meta-analyses to assess the impact of latitude on birth season-specific associations at both time points. RESULTS: We identified associations between birth season and DNAm (False Discovery Rate-adjusted p values < 0.05) at two CpGs at birth (winter-born) and four in the childhood (summer-born) analyses when compared to children born in autumn. Furthermore, we identified twenty-six differentially methylated regions (DMR) at birth (winter-born: 8, spring-born: 15, summer-born: 3) and thirty-two in childhood (winter-born: 12, spring and summer: 10 each) meta-analyses with few overlapping DMRs between the birth seasons or the two time points. The DMRs were associated with genes of known functions in tumorigenesis, psychiatric/neurological disorders, inflammation, or immunity, amongst others. Latitude-stratified meta-analyses [higher (≥ 50°N), lower (< 50°N, northern hemisphere only)] revealed differences in associations between birth season and DNAm by birth latitude. DMR analysis implicated genes with previously reported links to schizophrenia (LAX1), skin disorders (PSORS1C, LTB4R), and airway ...
نوع الوثيقة: article in journal/newspaper
وصف الملف: 148-; Electronic
اللغة: English
ردمك: 978-2-7520-1300-2
2-7520-1300-0
تدمد: 1868-7075
1868-7083
العلاقة: https://www.ncbi.nlm.nih.gov/pubmed/37697338Test; Clin Epigenetics, 15(1); orcid:0000-0003-2906-4035 (Sharp, Gemma C); ScopusID: 56898577600 (Sharp, Gemma C); Vol. 15, article 148; https://doi.org/10.1186/s13148-023-01542-5Test; 217065/Z/19/Z; BBI025751/1; BB/I025263/1; 848158; ES/K000357/1; MR/S009310/1; MR/S036520/1; 261357; RBc08-0027; R01ES009137; P42ES004705; P01ES018172; P42ES0470518; R24ES028524; RD83451101; 5P30CA082103; P01ES009605; R01ES021369; R01ES023067; R24 ES028529; R82670901; RD 83451301; QLRT-2001-00389; QLK1-CT-2002-30582; FP6-007036; FP7-289346; 633595; 322605; 01 GI 0825; P30ES007048; R01ES022216; K01ES017801; HHSN267200603423; HHSN267200603424; HHSN267200603426; HHSN275201300023I; HHSN2750008; R01 ES016443; R24ES030893; R01ES025531; 003953; R01 ES025531; R01 MD013299; 603946; 16320; 36224; 211250; 226756; 241604; 226285; 264357; 308333; ERC-2012-StG.310898; N1516112; G.0.873.11N.10; G059219; 308610; 20697; MOP 115071; #PJT-152989; 050-060-810; R01HD068437; 733206; 874739; 824989; 529051022; 529051023; MC_UU_00011/5; 2002B027; 2006B083; 911-03-016; 036894; R01DK076648; R01ES022934; UH3OD023248; CEX2018-000806-S; NIHR200166; WT101597MA; N01-ES-75558; UO1 NS 047537-01; UO1 NS 047537-06A1; 31V-125; FIS-PI04/1436; FIS-PI08/1151; FIS-PI11/00610; FIS-FEDER-PI06/0867; FIS-FEDER-PI03-1615; Red INMA G03/176; CB06/02/0041; 268479; W81XWH-20-1-0778; P20GM104416-09/8299; R01 AI091905; R01HL132321; R01 AI121226; R01 HL082925; 364; R01AI121226; MR/S025340/1; 221097; Z01-ES-49019; 262700; R21ES014947; R01ES016772; R01DK085173; P30 ES025128; R24ES028531; 2018-02640; 340-2013-5867; R01 HD034568; UH3 OD023286; R01 HL111108; R01 NR013945; MC_UU_12013/1; MC_UU_12013/2; MC_UU_12013/8; http://hdl.handle.net/10871/134180Test; Clinical Epigenetics
DOI: 10.1186/s13148-023-01542-5
الإتاحة: https://doi.org/10.1186/s13148-023-01542-5Test
http://hdl.handle.net/10871/134180Test
حقوق: © The Author(s) 2023. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0Test/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0Test/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. ; http://creativecommons.org/licenses/by/4.0Test/ ; CC BY
رقم الانضمام: edsbas.F3C608BF
قاعدة البيانات: BASE
الوصف
ردمك:9782752013002
2752013000
تدمد:18687075
18687083
DOI:10.1186/s13148-023-01542-5