دورية أكاديمية
Risk factors and outcome of COVID-19 in patients with hematological malignancies
| العنوان: | Risk factors and outcome of COVID-19 in patients with hematological malignancies |
|---|---|
| المؤلفون: | Piñana, José Luis, Martino, Rodrigo, García‑García, Irene, Parody, Rocío, Morales, María Dolores, Benzo, Gonzalo, Fox, Maria Laura |
| المساهمون: | Institut Català de la Salut, Piñana JL Hematology División, Hospital Universitario y Politécnico La Fe, Instituto de Investigación Sanitaria La Fe, Valencia, Spain. CIBERONC, Instituto Carlos III, Madrid, Spain. Division of Clinical Hematology, Hospital Universitario la Fe de Valencia, Avda Fernando Abril Martorell, 106 CP 46026 Valencia, Spain. Martino R Hematology División, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. García-García I Hematology División, Hospital Ramon y Cajal, Madrid, Spain. Parody R Hematology División, Institut Català Oncologia-Hospital Duran i Reynals, Barcelona, Spain. Morales MD Hematology División, Hospital de Guadalajara, Guadalajara, Spain. Benzo G Hematology División, Hospital La Princesa, Madrid, Spain. Fox L Servei d’Hematologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus |
| المصدر: | Scientia |
| بيانات النشر: | BMC |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Sang - Malalties, Hematologia oncològica, COVID-19 (Malaltia) - Mortalitat, DISEASES::Neoplasms::Neoplasms by Site::Hematologic Neoplasms, DISEASES::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections, Other subheadings::Other subheadings::Other subheadings::Other subheadings::/mortality, ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias hematológicas, ENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus, Otros calificadores::Otros calificadores::Otros calificadores::Otros calificadores::/mortalidad |
| الوصف: | Neoplàsies hematològiques; Factors de risc; Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV ; Neoplasias hematológicas; Factores de riesgo; Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV ; Hematological malignancies; Risk factors; Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV ; Background Prognostic factors of poor outcome in patients with hematological malignancies and COVID-19 are poorly defined. Patients and methods This was a Spanish transplant group and cell therapy (GETH) multicenter retrospective observational study, which included a large cohort of blood cancer patients with laboratory-confirmed SARS-CoV-2 infection through PCR assays from March 1st 2020 to May 15th 2020. Results We included 367 pediatric and adult patients with hematological malignancies, including recipients of autologous (ASCT) (n = 58) or allogeneic stem cell transplantation (allo-SCT) (n = 65) from 41 hospitals in Spain. Median age of patients was 64 years (range 1–93.8). Recipients of ASCT and allo-SCT showed lower mortality rates (17% and 18%, respectively) compared to non-SCT patients (31%) (p = 0.02). Prognostic factors identified for day 45 overall mortality (OM) by logistic regression multivariate analysis included age > 70 years [odds ratio (OR) 2.1, 95% confidence interval (CI) 1.2–3.8, p = 0.011]; uncontrolled hematological malignancy (OR 2.9, 95% CI 1.6–5.2, p < 0.0001); ECOG 3–4 (OR, 2.56, 95% CI 1.4–4.7, p = 0.003); neutropenia (< 0.5 × 109/L) (OR 2.8, 95% CI 1.3–6.1, p = 0.01); and a C-reactive protein (CRP) > 20 mg/dL (OR 3.3, 95% CI 1.7–6.4, p < 0.0001). In multivariate analysis of 216 patients with very severe COVID-19, treatment with azithromycin or low dose corticosteroids was associated with lower OM (OR 0.42, 95% CI 0.2–0.89 and OR 0.31, 95% CI 0.11–0.87, respectively, p = 0.02) whereas the use of hidroxycloroquine did not show significant improvement in OM (OR 0.64, 95% CI 0.37–1.1, P = 0.1). Conclusions In most patients with hematological malignancies COVID-19 mortality was directly driven by older age, ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2162-3619 |
| العلاقة: | Experimental Hematology & Oncology;9; https://doi.org/10.1186/s40164-020-00177-zTest; Piñana JL, Martino R, García-García I, Parody R, Morales MD, Benzo G, et al. Risk factors and outcome of COVID-19 in patients with hematological malignancies. Exp Hematol Oncol. 2020 Aug 25;9:21.; https://hdl.handle.net/11351/6447Test; 000566251400001 |
| DOI: | 10.1186/s40164-020-00177-z |
| الإتاحة: | https://doi.org/10.1186/s40164-020-00177-zTest https://hdl.handle.net/11351/6447Test |
| حقوق: | Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0Test/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.B7661CCB |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 21623619 |
|---|---|
| DOI: | 10.1186/s40164-020-00177-z |