دورية أكاديمية
Ovalbumin-induced plasma interleukin-4 levels are reduced in ceramide kinase-deficient DO11.10 RAG1 -/- mice
| العنوان: | Ovalbumin-induced plasma interleukin-4 levels are reduced in ceramide kinase-deficient DO11.10 RAG1 -/- mice |
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| المؤلفون: | Baumruker Thomas, Urtz Nicole, Niwa Satoru, Billich Andreas, Bornancin Frédéric |
| المصدر: | Lipids in Health and Disease, Vol 9, Iss 1, p 1 (2010) |
| بيانات النشر: | BMC |
| سنة النشر: | 2010 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Nutritional diseases. Deficiency diseases, RC620-627 |
| الوصف: | Ceramide kinase (CERK) produces the bioactive lipid ceramide-1-phosphate (C1P) and is a key regulator of ceramide and dihydroceramide levels. It is likely that CERK and C1P play a role in inflammatory processes but the cells involved and the mechanisms used remain to be clarified. In particular, the impact of CERK on T-cell biology has not been studied so far. Here, we used Cerk -/- mice backcrossed with DO11.10/RAG1 -/- mice to probe the effect of CERK ablation on T-cell activation. Levels of interleukin (IL)-2, IL-4, IL-5, IL-13, of tumor necrosis factor (TNF)-α, and of interferon (INF)-γ were recorded following ovalbumin challenge in vivo and using ovalbumin-treated splenocytes ex- vivo. Absence of CERK led to a significant decrease in the production of IL-4, thus suggesting that CERK may polarize T cells towards the T H 2 cell subtype. However, the importance of CERK to T H 2 cell biology will have to be investigated further because in a model of asthma, which is T H 2-cell driven, Cerk -/- mice responded like wild-type animals. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1476-511X |
| العلاقة: | http://www.lipidworld.com/content/9/1/1Test; https://doaj.org/toc/1476-511XTest; https://doaj.org/article/953758a8320f478db16e6d7516a4e3c3Test |
| DOI: | 10.1186/1476-511X-9-1 |
| الإتاحة: | https://doi.org/10.1186/1476-511X-9-1Test https://doaj.org/article/953758a8320f478db16e6d7516a4e3c3Test |
| رقم الانضمام: | edsbas.FF45FDF3 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 1476511X |
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| DOI: | 10.1186/1476-511X-9-1 |