دورية أكاديمية
Treg/Th17 imbalance and its clinical significance in patients with hepatitis B-associated liver cirrhosis
| العنوان: | Treg/Th17 imbalance and its clinical significance in patients with hepatitis B-associated liver cirrhosis |
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| المؤلفون: | Yong-Ting Lan, Zhen-li Wang, Peng Tian, Xiao-Na Gong, Yu-Chen Fan, Kai Wang |
| المصدر: | Diagnostic Pathology, Vol 14, Iss 1, Pp 1-9 (2019) |
| بيانات النشر: | BMC |
| سنة النشر: | 2019 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Hepatitis B-associated liver cirrhosis, Immune mechanism, Treg, Th17, Pathology, RB1-214 |
| الوصف: | Background Recent studies have shown that T cell-mediated cellular immune mechanisms play important roles in the progression of hepatitis B to liver cirrhosis, but the underlying mechanisms remain unclear. This present study was aimed to determine the relationship between Treg/Th17 and hepatitis B-associated liver cirrhosis. Methods The Treg and Th17 cell frequencies in the peripheral blood of all participants, including 93 patients with hepatitis B-associated liver cirrhosis and 40 healthy subjects, were measured by flow cytometer. Cox regression model and receiver operating characteristic(ROC) curves were applied to investigate the prognostic significance of Treg/Th17 ratio in decompensated liver cirrhosis. Results We observed the Treg/Th17 imbalance was present in patients with hepatitis B-associated liver cirrhosis, with reduced Treg cells in their peripheral blood, increased Th17 cells and decreased Treg/Th17 ratio. Treg and Th17 cells were negatively correlated. Treg/Th17 imbalance was closely related to the clinical stage of hepatitis B-associated liver cirrhosis. The Virus load, Treg frequencies and the Treg/Th17 ratio were independent factors predicting decompensated liver cirrhosis from a Cox regression model. The ROC analysis showed that the Treg/Th17 ratio was the best marker for predicting decompensated liver cirrhosis. Conclusions Treg/Th17 imbalance is involved in the pathogenesis of hepatitis B-associated liver cirrhosis and the Treg/Th17 ratio can be used as a potential marker for predicting decompensated liver cirrhosis. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1746-1596 |
| العلاقة: | http://link.springer.com/article/10.1186/s13000-019-0891-4Test; https://doaj.org/toc/1746-1596Test; https://doaj.org/article/4dff120c96704e75bd1fb050c2740707Test |
| DOI: | 10.1186/s13000-019-0891-4 |
| الإتاحة: | https://doi.org/10.1186/s13000-019-0891-4Test https://doaj.org/article/4dff120c96704e75bd1fb050c2740707Test |
| رقم الانضمام: | edsbas.9154442A |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 17461596 |
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| DOI: | 10.1186/s13000-019-0891-4 |