دورية أكاديمية
Engrafted glial progenitor cells yield long-term integration and sensory improvement in aged mice
| العنوان: | Engrafted glial progenitor cells yield long-term integration and sensory improvement in aged mice |
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| المؤلفون: | Zhiqi Yang, Mingyue Gong, Tingliang Jian, Jin Li, Chuanyan Yang, Qinlong Ma, Ping Deng, Yuxia Wang, Mingzhu Huang, Haoyu Wang, Shaofan Yang, Xiaowei Chen, Zhengping Yu, Manxia Wang, Chunhai Chen, Kuan Zhang |
| المصدر: | Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-10 (2022) |
| بيانات النشر: | BMC, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medicine (General) LCC:Biochemistry |
| مصطلحات موضوعية: | Glial progenitor cells, Transplantation, Endfeet, Aquaporin-4, Sensory response, Aging, Medicine (General), R5-920, Biochemistry, QD415-436 |
| الوصف: | Abstract Aging causes astrocyte morphological degeneration and functional deficiency, which impairs neuronal functions. Until now, whether age-induced neuronal deficiency could be alleviated by engraftment of glial progenitor cell (GPC) derived astrocytes remained unknown. In the current study, GPCs were generated from embryonic cortical neural stem cells in vitro and transplanted into the brains of aged mice. Their integration and intervention effects in the aged brain were examined 12 months after transplantation. Results indicated that these in-vitro-generated GPC-derived astrocytes possessed normal functional properties. After transplantation they could migrate, differentiate, achieve long-term integration, and maintain much younger morphology in the aged brain. Additionally, these GPC-derived astrocytes established endfeet expressing aquaporin-4 (AQP4) and ameliorate AQP4 polarization in the aged neocortex. More importantly, age-dependent sensory response degeneration was reversed by GPC transplantation. This work demonstrates that rejuvenation of the astrocyte niche is a promising treatment to prevent age-induced degradation of neuronal and behavioral functions. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1757-6512 |
| العلاقة: | https://doaj.org/toc/1757-6512Test |
| DOI: | 10.1186/s13287-022-02959-0 |
| الوصول الحر: | https://doaj.org/article/5da4bb72f8644efb92b249feb21c5e38Test |
| رقم الانضمام: | edsdoj.5da4bb72f8644efb92b249feb21c5e38 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17576512 |
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| DOI: | 10.1186/s13287-022-02959-0 |