Protection against neonatal enteric colibacillosis employing E. Coli-derived outer membrane vesicles in formulation and without vitamin D3
| العنوان: | Protection against neonatal enteric colibacillosis employing E. Coli-derived outer membrane vesicles in formulation and without vitamin D3 |
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| المؤلفون: | Gholamreza Nikbakht Brujeni, Babak Beikzadeh |
| المصدر: | BMC Research Notes, Vol 11, Iss 1, Pp 1-8 (2018) BMC Research Notes |
| بيانات النشر: | BMC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, Offspring, medicine.medical_treatment, lcsh:Medicine, Outer membrane vesicles, Passive immunity, Biology, medicine.disease_cause, General Biochemistry, Genetics and Molecular Biology, Microbiology, 03 medical and health sciences, Mice, Immune system, Enterotoxigenic Escherichia coli, medicine, Animals, lcsh:Science (General), lcsh:QH301-705.5, Escherichia coli Infections, Cholecalciferol, Mice, Inbred BALB C, Escherichia coli Vaccines, lcsh:R, General Medicine, Diarrhea, Intestinal Diseases, Research Note, 030104 developmental biology, Immunization, Animals, Newborn, lcsh:Biology (General), biology.protein, Female, medicine.symptom, Antibody, Bacterial outer membrane, Vitamin D3, Bacterial Outer Membrane Proteins, lcsh:Q1-390 |
| الوصف: | Objective Enterotoxigenic Escherichia Coli (ETEC) is the cause of diarrhea and even death in humans and offspring of animals. Outer membrane vesicles (OMVs) of the ETEC was prepared and its potential as a vaccine candidate against enteric colibacillosis in neonatal mice was evaluated. Dam mice intradermally injected with ETEC-derived OMVs and OMVs plus an active form of vitamin D3 (avD3). Mucosal and systemic immune responses in mice and passive immunity protection against ETEC lethality in their offspring was investigated. Results Immunization of adult mice via ETEC-derived OMV alone and in formulation with avD3 protect offspring from ETEC-induced lethality. Nevertheless, avD3 did not indicate a positive effect on mucosal and systemic immune responses. Only the combination of OMV plus avD3 elicited a significant (P |
| اللغة: | English |
| تدمد: | 1756-0500 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::556eb98ff0f027ccc704256287c96186Test http://link.springer.com/article/10.1186/s13104-018-3442-2Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....556eb98ff0f027ccc704256287c96186 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17560500 |
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