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Higher polygenic risk for melanoma is associated with improved survival in a high ultraviolet radiation setting

التفاصيل البيبلوغرافية
العنوان: Higher polygenic risk for melanoma is associated with improved survival in a high ultraviolet radiation setting
المؤلفون: Mathias Seviiri, Richard A. Scolyer, D. Timothy Bishop, Julia A. Newton-Bishop, Mark M. Iles, Serigne N. Lo, Johnathan R. Stretch, Robyn P. M. Saw, Omgo E. Nieweg, Kerwin F. Shannon, Andrew J. Spillane, Scott D. Gordon, Catherine M. Olsen, David C. Whiteman, Maria Teresa Landi, John F. Thompson, Georgina V. Long, Stuart MacGregor, Matthew H. Law
المصدر: Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-13 (2022)
بيانات النشر: BMC, 2022.
سنة النشر: 2022
المجموعة: LCC:Medicine
مصطلحات موضوعية: Melanoma, Melanoma-specific survival, Polygenic risk score, Genome-wide association study, Skin cancer, Medicine
الوصف: Abstract Background The role of germline genetic factors in determining survival from cutaneous melanoma (CM) is not well understood. Objective To perform a genome-wide association study (GWAS) meta-analysis of melanoma-specific survival (MSS), and test whether a CM-susceptibility polygenic risk score (PRS) is associated with MSS. Methods We conducted two Cox proportional-hazard GWAS of MSS using data from the Melanoma Institute Australia, a high ultraviolet (UV) radiation setting (MIA; 5,762 patients with melanoma; 800 melanoma deaths) and UK Biobank (UKB: 5,220 patients with melanoma; 241 melanoma deaths), and combined them in a fixed-effects meta-analysis. Significant (P
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1479-5876
العلاقة: https://doaj.org/toc/1479-5876Test
DOI: 10.1186/s12967-022-03613-2
الوصول الحر: https://doaj.org/article/ef000a44851f4e28a8d7423a1ed25890Test
رقم الانضمام: edsdoj.f000a44851f4e28a8d7423a1ed25890
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14795876
DOI:10.1186/s12967-022-03613-2