Bisphenol A exposure and type 2 diabetes mellitus risk: a meta-analysis
| العنوان: | Bisphenol A exposure and type 2 diabetes mellitus risk: a meta-analysis |
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| المؤلفون: | Yoon Jeong Choi, Jung-eun Lim, Semi Hwang, Sun Ha Jee |
| المصدر: | BMC Endocrine Disorders, Vol 18, Iss 1, Pp 1-10 (2018) BMC Endocrine Disorders |
| بيانات النشر: | BMC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Blood Glucose, endocrine system, Bisphenol A, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Urine, 010501 environmental sciences, Hemoglobin A1c (HbA1c), 01 natural sciences, lcsh:Diseases of the endocrine glands. Clinical endocrinology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Phenols, Diabetes mellitus, Internal medicine, Medicine, Humans, Estrogens, Non-Steroidal, Obesity, Benzhydryl Compounds, 0105 earth and related environmental sciences, lcsh:RC648-665, business.industry, Bisphenol a (BPA), Fasting plasma glucose, Type 2 Diabetes Mellitus, General Medicine, Odds ratio, Environmental Exposure, Endocrine disrupting chemicals (EDCs), medicine.disease, Confidence interval, Meta-analysis, Type 2 diabetes mellitus (T2DM), Cross-Sectional Studies, chemistry, Diabetes Mellitus, Type 2, Case-Control Studies, business, Diabetes mellitus (DM), Research Article |
| الوصف: | Background This meta-analytic study explored the relationship between the risk of type 2 diabetes mellitus (T2DM) and bisphenol A concentrations. Methods The Embase and Medline (PubMed) databases were searched, using relevant keywords, for studies published between 1980 and 2018. A total of 16 studies, twelve cross-sectional, two case-control and one prospective, were included in the meta-analysis. The odds ratio (OR) and its 95% confidence interval (CI) were determined across the sixteen studies. The OR and its 95% CI of diabetes associated with bisphenol A were estimated using both fixed-effects and random-effects models. Results A total of 41,320 subjects were included. Fourteen of the sixteen studies included in the analysis provided measurements of urine bisphenol A levels and two study provided serum bisphenol A levels. Bisphenol A concentrations in human bio-specimens showed positive associations with T2DM risk (OR 1.28, 95% CI 1.14, 1.44). A sensitivity analysis indicated that urine bisphenol A concentrations were positively associated with T2DM risk (OR 1.20, 95% CI 1.09, 1.31). Conclusions This meta-analysis indicated that Bisphenol A exposure is positively associated with T2DM risk in humans. Electronic supplementary material The online version of this article (10.1186/s12902-018-0310-y) contains supplementary material, which is available to authorized users. |
| اللغة: | English |
| تدمد: | 1472-6823 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2663596db6778ff20ac50263fce0a5fTest http://link.springer.com/article/10.1186/s12902-018-0310-yTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b2663596db6778ff20ac50263fce0a5f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14726823 |
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