Placental hypoxia-regulating network in relation to birth weight and ponderal index: the ENVIRONAGE Birth Cohort Study
| العنوان: | Placental hypoxia-regulating network in relation to birth weight and ponderal index: the ENVIRONAGE Birth Cohort Study |
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| المؤلفون: | Karen Vrijens, Narjes Madhloum, Wilfried Gyselaers, Tim S. Nawrot, Maria Tsamou |
| المصدر: | Journal of Translational Medicine, Vol 16, Iss 1, Pp 1-8 (2018) Journal of Translational Medicine |
| بيانات النشر: | BMC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, Birth weight, Placenta, lcsh:Medicine, General Biochemistry, Genetics and Molecular Biology, Cohort Studies, Andrology, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, Gene expression, Humans, Medicine, PTEN, RNA, Messenger, HIF1α, Hypoxia, biology, business.industry, Research, lcsh:R, Gene Expression Regulation, Developmental, General Medicine, Hypoxia (medical), medicine.disease, MicroRNAs, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, biology.protein, Female, ISCU, birth weight, gene expression, HIF1 alpha, hypoxia, placenta, medicine.symptom, business, Cohort study |
| الوصف: | Background: HIF1 alpha, miR-210 and its downstream targets ISCU, COX-10, RAD52 and PTEN are all part of the placental hypoxia-responsive network. Tight regulation of this network is reguired to prevent development of maternal-fetal complications such as fetal growth restriction. HIF1 alpha expression is increased in preeclamptic placentae, but little is known about its association with birth weight in normal pregnancies. Methods: We measured placental levels of HIF1 alpha, miR-20a, miR-210, ISCU, COX-10, RAD52 and PTEN in 206 mother-newborn pairs of the ENVIRONAGE birth cohort. Results: Placental HIF1 alpha gene expression was inversely associated with the ponderal index (PI): for a doubling in placental HIF1 alpha expression, PI decreased by 6.7% (95% confidence interval [Cl] 1.3 to 12.0%, p = 0.01). Placental RAD52 expression also displayed an inverse association with PI, a doubling in gene expression was associated with a 6.2% (Cl 0.2 to 12.1% p = 0.04) decrease in PI. As for birth weight, we observed a significant association with placental miR-20a expression only in boys, where a doubling in miR-20a expression is associated with a 54.2 g (Cl 0.6 to 108 g, p = 0.05) increase in birth weight. Conclusions: The decrease in fetal growth associated with expression of hypoxia-network members HIF1 alpha, RAD52 and miR-20a indicates that this network is important in potential intrauterine insults. The ENVIRONAGE birth cohort is supported by grants from the European Research Council (ERC-2012-StG 310898) and Flemish Research Council (FWO G073315N). Karen Vrijens is a postdoctoral fellow of the FWO (12D7714N). |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1479-5876 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc27a3b95ff0019a8701e2a6a1723a51Test http://link.springer.com/article/10.1186/s12967-017-1375-5Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....dc27a3b95ff0019a8701e2a6a1723a51 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14795876 |
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