27-Hydroxycholesterol, cognition, and brain imaging markers in the FINGER randomized controlled trial
| العنوان: | 27-Hydroxycholesterol, cognition, and brain imaging markers in the FINGER randomized controlled trial |
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| المؤلفون: | Angel Cedazo-Minguez, Nina Kemppainen, Ingemar Björkhem, Juha O. Rinne, Miia Kivipelto, Hilkka Soininen, Alina Solomon, Tiina Laatikainen, Julen Goikolea, Laura Paternain, Anna Sandebring-Matton, Tiia Ngandu |
| المصدر: | Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-12 (2021) Alzheimer's Research & Therapy |
| بيانات النشر: | BMC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, Neurology, Cognitive Neuroscience, Population, Neuroimaging, Context (language use), Neuropsychological Tests, lcsh:RC346-429, law.invention, lcsh:RC321-571, 03 medical and health sciences, Cognition, 0302 clinical medicine, Randomized controlled trial, law, Internal medicine, Humans, Medicine, Dementia, Cholesterol metabolism, Cognitive Dysfunction, education, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Finland, lcsh:Neurology. Diseases of the nervous system, Aged, 27-Hydroxycholesterol, education.field_of_study, business.industry, Research, Brain, medicine.disease, Magnetic Resonance Imaging, Hydroxycholesterols, Cognitive training, Cross-Sectional Studies, 030104 developmental biology, Multimodal intervention, Neurology (clinical), business, 030217 neurology & neurosurgery, Geriatric psychiatry, Biomarkers |
| الوصف: | Background 27-Hydroxycholesterol (27-OH), the main circulating oxysterol in humans and the potential missing link between peripheral hypercholesterolemia and Alzheimer’s disease (AD), has not been investigated previously in relation to cognition and neuroimaging markers in the context of preventive interventions. Methods The 2-year Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) included older individuals (60–77 years) at increased risk for dementia but without dementia or substantial cognitive impairment from the general population. Participants were randomized to a multidomain intervention (diet, exercise, cognitive training, and vascular risk management) or control group (general health advice) in a 1:1 ratio. Outcome assessors were masked to group allocation. This FINGER exploratory sub-study included 47 participants with measures of 27-OH, cognition, brain MRI, brain FDG-PET, and PiB-PET. Linear regression models were used to assess the cross-sectional and longitudinal associations between 27-OH, cognition, and neuroimaging markers, considering several potential confounders/intervention effect modifiers. Results 27-OH reduction during the intervention was associated with improvement in cognition (especially memory). This was not observed in the control group. The intervention reduced 27-OH particularly in individuals with the highest 27-OH levels and younger age. No associations were found between changes in 27-OH levels and neuroimaging markers. However, at baseline, a higher 27-OH was associated with lower total gray matter and hippocampal volume, and lower cognitive scores. These associations were unaffected by total cholesterol levels. While sex seemed to influence associations at baseline, it did not affect longitudinal associations. Conclusion 27-OH appears to be a marker not only for dementia/AD risk, but also for monitoring the effects of preventive interventions on cholesterol metabolism. Trial registration ClinicalTrials.gov, NCT01041989. Registered on 4 January 2010 |
| اللغة: | English |
| تدمد: | 1758-9193 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1af5e953ce5aaa92c83bce950745b842Test https://doaj.org/article/331e6ffc2e9744dcabc5a657dfe423adTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1af5e953ce5aaa92c83bce950745b842 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17589193 |
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