Mesenchymal stem cell therapy in pulmonary fibrosis: a meta-analysis of preclinical studies
| العنوان: | Mesenchymal stem cell therapy in pulmonary fibrosis: a meta-analysis of preclinical studies |
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| المؤلفون: | Deng-Yuan Li, Dan-Xiong Sun, Dan-Dan Pu, Yunhui Zhang, Rufang Li |
| المصدر: | Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-11 (2021) Stem Cell Research & Therapy |
| بيانات النشر: | BMC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Oncology, medicine.medical_specialty, Medicine (General), Medicine (miscellaneous), Preclinical studies, QD415-436, Cochrane Library, Mesenchymal Stem Cell Transplantation, Biochemistry, Genetics and Molecular Biology (miscellaneous), Biochemistry, Pulmonary fibrosis, R5-920, Internal medicine, medicine, Animals, Survival rate, Mesenchymal stem cell, Lung, business.industry, Research, Mesenchymal Stem Cells, Cell Biology, Odds ratio, medicine.disease, Confidence interval, Meta-analysis, medicine.anatomical_structure, Respiratory failure, Molecular Medicine, Therapy, business |
| الوصف: | Background Pulmonary fibrosis (PF) is a devastating disease characterized by remodeling of lung architecture and abnormal deposition of fibroblasts in parenchymal tissue and ultimately results in respiratory failure and death. Preclinical studies suggest that mesenchymal stem cell (MSC) administration may be a safe and promising option in treating PF. The objective of our meta-analysis is to assess the efficacy of MSC therapy in preclinical models of PF. Methods We performed a comprehensive literature search in PubMed, EMBASE, Web of Science, and Cochrane Library databases from inception to March 17, 2021. Studies that assessed the efficacy of MSC therapy to animals with PF were included. The SYRCLE bias risk tool was employed to evaluate the bias of included studies. The primary outcomes included survival rate and pulmonary fibrosis scores. Meta-analysis was conducted via Cochrane Collaboration Review Manager (version 5.4) and Stata 14.0 statistical software. Results A total of 1120 articles were reviewed, of which 24 articles met inclusion criteria. Of these, 12 studies evaluated the survival rate and 20 studies evaluated pulmonary fibrosis scores. Compared to the control group, MSC therapy was associated with an improvement in survival rate (odds ratios (OR) 3.10, 95% confidence interval (CI) 2.06 to 4.67, P < 0.001, I2 = 0%) and a significant reduction in pulmonary fibrosis scores (weighted mean difference (WMD) 2.05, 95% CI −2.58 to −1.51, P < 0.001, I2 = 90%). Conclusions MSC therapy is a safe and effective method that can significantly improve the survival and pulmonary fibrosis of PF animals. These results provide an important basis for future translational clinical studies. |
| اللغة: | English |
| تدمد: | 1757-6512 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4288c406a5d1c2378d73108baa51ac23Test https://doaj.org/article/382c99fa8b204f83ad336f6b025d2fe7Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4288c406a5d1c2378d73108baa51ac23 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17576512 |
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