دورية أكاديمية
Biofortified red mottled beans ( Phaseolus vulgaris L.) in a maize and bean diet provide more bioavailable iron than standard red mottled beans: Studies in poultry ( Gallus gallus ) and an in vitro digestion/Caco-2 model
| العنوان: | Biofortified red mottled beans ( Phaseolus vulgaris L.) in a maize and bean diet provide more bioavailable iron than standard red mottled beans: Studies in poultry ( Gallus gallus ) and an in vitro digestion/Caco-2 model |
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| المؤلفون: | Glahn Raymond P, Blair Matthew W, Tako Elad |
| المصدر: | Nutrition Journal, Vol 10, Iss 1, p 113 (2011) |
| بيانات النشر: | BMC |
| سنة النشر: | 2011 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Beans, biofortification, iron bioavailability, in vitro digestion/Caco- 2 cell model, broiler chicken, intestine, Nutrition. Foods and food supply, TX341-641, Nutritional diseases. Deficiency diseases, RC620-627 |
| الوصف: | Background Our objective was to compare the capacities of biofortified and standard colored beans to deliver iron (Fe) for hemoglobin synthesis. Two isolines of large-seeded, red mottled Andean beans ( Phaseolus vulgaris L.), one standard ("Low Fe") and the other biofortified ("High Fe") in Fe (49 and 71 μg Fe/g, respectively) were used. This commercial class of red mottled beans is the preferred varietal type for most of the Caribbean and Eastern and Southern Africa where almost three quarters of a million hectares are grown. Therefore it is important to know the affect of biofortification of these beans on diets that simulate human feeding studies. Methods Maize-based diets containing the beans were formulated to meet the nutrient requirements for broiler except for Fe (Fe concentrations in the 2 diets were 42.9 ± 1.2 and 54.6 ± 0.9 mg/kg). One day old chicks ( Gallus gallus ) were allocated to the experimental diets (n = 12). For 4 wk, hemoglobin, feed-consumption and body-weights were measured. Results Hemoglobin maintenance efficiencies (HME) (means ± SEM) were different between groups on days 14 and 21 of the experiment (P < 0.05). Final total body hemoglobin Fe contents were different between the standard (12.58 ± 1.0 mg {0.228 ± 0.01 μmol}) and high Fe (15.04 ± 0.65 mg {0.273 ± 0.01 μmol}) bean groups (P < 0.05). At the end of the experiment, tissue samples were collected from the intestinal duodenum and liver for further analyses. Divalent-metal-transporter-1, duodenal-cytochrome-B, and ferroportin expressions were higher and liver ferritin was lower (P < 0.05) in the standard group vs. the biofortified group. In-vitro analysis showed lower iron bioavailability in cells exposed to standard ("Low Fe") bean based diet. Conclusions We conclude that the in-vivo results support the in-vitro observations; biofortified colored beans contain more bioavailable-iron than standard colored beans. In addition, biofortified beans seems to be a promising vehicle for increasing intakes of bioavailable ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1475-2891 |
| العلاقة: | http://www.nutritionj.com/content/10/1/113Test; https://doaj.org/toc/1475-2891Test; https://doaj.org/article/05db6460edf9438097d69801a21c8781Test |
| DOI: | 10.1186/1475-2891-10-113 |
| الإتاحة: | https://doi.org/10.1186/1475-2891-10-113Test https://doaj.org/article/05db6460edf9438097d69801a21c8781Test |
| رقم الانضمام: | edsbas.2EB8699E |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14752891 |
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| DOI: | 10.1186/1475-2891-10-113 |