المؤلفون: Mina, Sharbatoghli, Parisa, Shamshiripour, Fahimeh, Fattahi, Elham, Kalantari, Zohre, Habibi Shams, Mahshid, Panahi, Mehdi, Totonchi, Zeynab, Asadi-Lari, Zahra, Madjd, Leili, Saeednejad Zanjani

المصدر: Journal of Ovarian Research, Vol 15, Iss 1, Pp 1-17 (2022)
Journal of Ovarian Research

مصطلحات موضوعية: Adult, Adolescent, Kaplan-Meier Estimate, Aldehyde Dehydrogenase 1 Family, Young Adult, Biomarkers, Tumor, Humans, Protein Interaction Maps, ALDH1A1, Aged, Ovarian Neoplasms, Serous ovarian carcinoma (SOC), SALL4, Research, Ovary, Retinal Dehydrogenase, Obstetrics and Gynecology, Gynecology and obstetrics, Middle Aged, Prognosis, eye diseases, Gene Expression Regulation, Neoplastic, Immunohistochemistry (IHC), Oncology, Tissue microarray (TMA), Neoplastic Stem Cells, RG1-991, Female, Transcription Factors

الوصف: Background Spalt-like transcription factor 4 (SALL4) and aldehyde dehydrogenase1 family member A1 (ALDH1A1) expressing cells have been characterized as possessing stem cell-like properties known as cancer stem cell marker in serous ovarian carcinoma (SOC). Methods The association between SALL4 and ALDH1A1 was observed based on literature review and bioinformatics tools. Therefore, this study aimed to investigate the association between the co-expression of SALL4/ALDH1A1 proteins and clinicopathological parameters and their prognostic value in SOC patients using immunohistochemical staining on tissue microarrays (TMAs). Furthermore, benign tumors and normal tissue samples were compared with the expression of the tumor tissue samples. Results Increased co-expression of SALL4/ALDH1A1 was found to be significantly associated with the advanced FIGO stage (P = 0.047), and distant metastasis (P = 0.028). The results of Kaplan–Meier survival analysis indicated significant differences between disease- specific survival (DSS; P = 0.034) or progression-free survival (PFS; P = 0.018) and the patients with high and low co-expression of SALL4/ALDH1A1, respectively. Furthermore, high level co-expression of SALL4/ALDH1A1 was a significant predictor of worse DSS and PFS in the univariate analysis. The data also indicated that the co-expression of SALL4/ALDH1A1 was an independent prognostic factor affecting PFS. Moreover, the co-expression of SALL4/ALDH1A1 added prognostic values of DSS in patients with SOC who had grade III versus grade I in multivariate analysis. Conclusions Our data demonstrated that high co-expression of SALL4/ALDH1A1 was found to be significantly associated with tumor aggressiveness and worse DSS or PFS in SOC patients. Therefore, co-expression of SALL4/ALDH1A1 may serve as a potential prognostic biomarker of cancer progression in these cases.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f6ba2f67a4cc94979cd792bcec32878Test
https://doaj.org/article/1fec4522edfc42ef9cee492b249659bbTest

المؤلفون: Hideaki Kaneto, Masashi Shimoda, Shuhei Nakanishi, Kohei Kaku, Shinji Kamei, Tomohiko Kimura, Atsushi Obata, Yoshiro Fushimi, Junpei Sanada, Fuminori Tatsumi, Tomoatsu Mune

المصدر: BMC Endocrine Disorders, Vol 21, Iss 1, Pp 1-5 (2021)
BMC Endocrine Disorders

مصطلحات موضوعية: Adult, Male, Pathology, medicine.medical_specialty, congenital, hereditary, and neonatal diseases and abnormalities, endocrine system diseases, Endocrinology, Diabetes and Metabolism, Case Report, Germline, Diseases of the endocrine glands. Clinical endocrinology, Frameshift mutation, Proto-Oncogene Proteins, medicine, Multiple Endocrine Neoplasia Type 1, Humans, MEN1, A giant cervical lipoma, Multiple endocrine neoplasia, Frameshift Mutation, Parathyroidectomy, business.industry, Pancreatic Diseases, General Medicine, Lipoma, medicine.disease, Prognosis, RC648-665, Pancreatic endocrine tumor, medicine.anatomical_structure, Multiple fatty deposits in the pancreas, Pancreas, business, Primary hyperparathyroidism

الوصف: Background Multiple endocrine neoplasia type 1 (MEN1) is a syndrome characterized by pituitary neoplasia, primary hyperparathyroidism and pancreatic endocrine tumor. Here we show a case of MEN1 with a germline frameshift mutation in its gene accompanied by a giant cervical lipoma and multiple fatty deposits in the pancreas. Case presentation A 28-year-old man noticed the decreased visual acuity of both eyes and visited our institution. Since he was diagnosed as visual disturbance and brain computer tomography (CT) showed a mass in the pituitary fossa, he was hospitalized in our institution. Endoscopic trans-sphenoidal hypophysectomy and total parathyroidectomy with auto-transplantation were performed, and a giant cervical lipoma was resected. Furthermore, in genetic search, we found a germline frameshift mutation in MEN1 gene leading to the appearance of a new stop codon. Conclusions We should bear in m ind that giant skin lipoma and multiple abnormal fatty deposits in the pancreas could be complicated with MEN1.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bda79ae2f395f76272171ea896e299a7Test
https://doaj.org/article/8c88e3dc93f8443f96a16f8ac303e2baTest

المؤلفون: Angela A. Rivellese, Lutgarda Bozzetto, Brunella Capaldo, Luisa Palmisano, Giuseppe Della Pepa, Gabriele Riccardi, Maria Masulli, Roberta Lupoli, Nicola Tecce

المساهمون: Tecce, N., Masulli, M., Lupoli, R., Della Pepa, G., Bozzetto, L., Palmisano, L., Rivellese, A. A., Riccardi, G., Capaldo, B.

المصدر: Cardiovascular Diabetology, Vol 19, Iss 1, Pp 1-9 (2020)
Cardiovascular Diabetology

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, lcsh:Diseases of the circulatory (Cardiovascular) system, Time Factors, Endocrinology, Diabetes and Metabolism, Concordance, Population, Disease, ESC guideline, Risk Assessment, Young Adult, Internal medicine, Diabetes mellitus, medicine, Health Status Indicators, Humans, education, Angiology, Retrospective Studies, Original Investigation, Type 1 diabetes, education.field_of_study, business.industry, Middle Aged, medicine.disease, Prognosis, Cardiovascular risk, STENO Type 1 risk engine, Diabetes Mellitus, Type 1, Cardiovascular Diseases, Heart Disease Risk Factors, ESC guidelines, lcsh:RC666-701, Cohort, Female, Cardiology and Cardiovascular Medicine, business, Risk classification, Algorithms

الوصف: BackgroundPatients with type 1 diabetes (T1D) have higher mortality risk compared to the general population; this is largely due to increased rates of cardiovascular disease (CVD). As accurate CVD risk stratification is essential for an appropriate preventive strategy, we aimed to evaluate the concordance between 2019 European Society of Cardiology (ESC) CVD risk classification and the 10-year CVD risk prediction according to the Steno Type 1 Risk Engine (ST1RE) in adults with T1D.MethodsA cohort of 575 adults with T1D (272F/303M, mean age 36 ± 12 years) were studied. Patients were stratified in different CVD risk categories according to ESC criteria and the 10-year CVD risk prediction was estimated with ST1RE within each category.ResultsMen had higher BMI, WC, SBP than women, while no difference was found in HbA1c levels between genders. According to the ESC classification, 92.5% of patients aged 20 years) alone identified few patients (ConclusionsUsing ESC criteria, a large proportion (45%) of T1D patients without CVD are classified at very high CVD risk; however, among them, none of those

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8048c5130d1ddf0a5cbb466f4a0b7c6Test
http://link.springer.com/article/10.1186/s12933-020-01137-xTest

المؤلفون: Innocent Okpe, Ejiofor Ugwu, Ignatius Ezeani, Marcelina Enamino, Ibrahim Gezawa, Olufunmilayo Adeleye

المصدر: BMC Endocrine Disorders, Vol 20, Iss 1, Pp 1-10 (2020)
BMC Endocrine Disorders

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Nigeria, 030209 endocrinology & metabolism, lcsh:Diseases of the endocrine glands. Clinical endocrinology, Amputation, Surgical, Sepsis, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Diabetes mellitus, Internal medicine, Medicine, Humans, In patient, Diabetic Nephropathies, Intrahospital mortality, 030212 general & internal medicine, Hospital Mortality, Renal impairment, Foot Ulcer, Aged, Heart Failure, Type 1 diabetes, Proteinuria, lcsh:RC648-665, business.industry, Predictors, Wagner grading, General Medicine, Middle Aged, medicine.disease, Prognosis, Diabetic foot, Diabetic Foot, Hospitalization, Diabetic foot ulcer, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Diabetic foot ulcers, Observational study, Female, medicine.symptom, business, Diabetic Angiopathies, Research Article

الوصف: Background Diabetic foot ulcers (DFU) are associated with high morbidity and mortality globally. Mortality in patients hospitalized for DFU in Nigeria is unacceptably high. This study was undertaken to determine factors that predict mortality in patients hospitalized for DFU in Nigeria. Methods The current study was part of Multi-centre Evaluation of Diabetic Foot Ulcer in Nigeria (MEDFUN), an observational study conducted in six tertiary healthcare institutions across the 6 geopolitical zones of Nigeria. Consecutive type 1 or 2 diabetic patients hospitalized for DFU who consented to participate were recruited and subjected to relevant clinical, biochemical, and radiological assessments and multidisciplinary care until discharge or death. Data for type 1 diabetes mellitus (DM) patients were expunged from current mortality analysis due to their small number. Results Three hundred and twenty-three type 2 DM subjects with mean age and mean duration of DM of 57.2 ± 11.4 years and 8.7 ± 5.8 years respectively participated in this study. The median duration of ulcers was 39 days with a range of 28 to 54 days and the majority (79.9%) presented with advanced ulcers of at least Wagner grade 3. Mortality of 21.4% was recorded in the study, with the highest mortality observed among subjects with Wagner grade 5. Variables significantly associated with mortality with their respective p values were DM duration more than 120 months (p 0.005), ulcer duration > 1 month (p 0.020), ulcer severity of Wagner grade 3 and above (p 0.001), peripheral arterial disease (p 0.005), proteinuria (p p p p p 0.027), and renal impairment (p Conclusions This study showed high intra-hospital mortality among patients with DFU, with the majority of deaths occurring among those with advanced ulcers, bacteraemia, cardiac failure, and renal impairment. Prompt attention to these factors might help improve survival from DFU in Nigeria.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87f345d9d9b1ab254afb7525efedf88eTest
http://link.springer.com/article/10.1186/s12902-020-00614-4Test

المؤلفون: Laurits Juhl Heinsen, Gokulan Pararajasingam, Johanna Larsson, Thomas Rueskov Andersen, Rasmus Møgelvang, Jørgen Hangaard, Søren Auscher, Kenneth Egstrup, Brian Bridal Løgstrup

المصدر: BMC Cardiovascular Disorders, Vol 21, Iss 1, Pp 1-13 (2021)
Pararajasingam, G, Heinsen, L J, Larsson, J, Andersen, T R, Løgstrup, B B, Auscher, S, Hangaard, J, Møgelvang, R & Egstrup, K 2021, ' Diabetic microvascular complications are associated with reduced global longitudinal strain independent of atherosclerotic coronary artery disease in asymptomatic patients with diabetes mellitus : a cross-sectional study ', BMC Cardiovascular Disorders, vol. 21, 269 . https://doi.org/10.1186/s12872-021-02063-wTest
BMC Cardiovascular Disorders

مصطلحات موضوعية: Male, Global longitudinal strain, Computed Tomography Angiography, Diabetic Cardiomyopathies, Denmark, Coronary Artery Disease, 030204 cardiovascular system & hematology, Coronary Angiography, Ventricular Function, Left, Coronary artery disease, Ventricular Dysfunction, Left, 0302 clinical medicine, Diabetes mellitus, Risk Factors, Outpatient clinic, 030212 general & internal medicine, Middle Aged, Prognosis, Echocardiography, Doppler, Cardiac surgery, Asymptomatic, Plaque burden, Echocardiography, Cardiology, Female, medicine.symptom, Cardiology and Cardiovascular Medicine, Research Article, Adult, medicine.medical_specialty, Microvascular complications, Risk Assessment, 03 medical and health sciences, Predictive Value of Tests, Internal medicine, medicine, Humans, Diseases of the circulatory (Cardiovascular) system, Aged, Angiology, Type 1 diabetes, business.industry, Microcirculation, medicine.disease, Cross-Sectional Studies, Diabetes Mellitus, Type 2, RC666-701, Asymptomatic Diseases, business, Body mass index, Diabetic Angiopathies

الوصف: Background Reduced left ventricular function, assessed by global longitudinal strain (GLS), is sometimes observed in asymptomatic patients with diabetes mellitus (DM) and is often present in patients with diabetes-related microvascular complications. Our aim was to assess the association between microvascular complications, coronary artery plaque burden (PB) and GLS in asymptomatic patients with DM and non-obstructive coronary artery disease (CAD). Methods This cross-sectional study included patients with DM without any history, symptoms or objective evidence of obstructive CAD. All patients were identified in the outpatient Clinic of Endocrinology at Odense University Hospital Svendborg. An echocardiography and a coronary computed tomography angiography were performed to assess GLS and the degree of CAD, respectively. A coronary artery stenosis Results Two hundred and twenty-two patients were included, of whom 172 (77%) had type 2 DM and 50 (23%) had type 1 diabetes. One hundred and eleven (50%) patients had microvascular complications. GLS decreased as the burden of microvascular complications increased (P-trend = 0.01): no microvascular complications, GLS (− 16.4 ± 2.5%), 1 microvascular complication (− 16.0 ± 2.5%) and 2–3 microvascular complications (− 14.9 ± 2.8%). The reduction in GLS remained significant after multivariable adjustment (β 0.50 [95% CI 0.11–0.88], p = 0.01). BMI (β 0.12 [95% CI 0.05–0.19]) and MAP (β 0.05 [95% CI 0.01–0.08]) were associated with reduced GLS. In addition, an increased number of microvascular complications was associated with increased PB (β 2.97 [95% CI 0.42–5.51], p = 0.02) in a univariable linear regression model, whereas there was no significant association between PB and GLS. Conclusions The burden of microvascular complications was associated with reduced GLS independent of other cardiovascular risk factors in asymptomatic patients with DM and non-obstructive CAD. In addition, the burden of microvascular complications was associated with increasing PB, whereas PB was not associated with GLS.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7354a22018e22dd02e46833531a7fd88Test
https://doaj.org/article/b481711d27914233843a352a05a27001Test

المؤلفون: Antic Slobodan, Rančić Nataša, Radojkovic Danijela, Radenkovic Sasa, Kocic Radivoj, Ciric Vojislav, Pesic Milica

المصدر: BMC Endocrine Disorders, Vol 20, Iss 1, Pp 1-7 (2020)
BMC Endocrine Disorders

مصطلحات موضوعية: Adult, Male, Adolescent, Endocrinology, Diabetes and Metabolism, Type 1 diabetes mellitus, Disease, lcsh:Diseases of the endocrine glands. Clinical endocrinology, Young Adult, Diabetes mellitus, Incidence trends, Trend, Medicine, Humans, Young adult, Age of Onset, Child, Type 1 diabetes, lcsh:RC648-665, business.industry, Incidence (epidemiology), Incidence, Infant, Newborn, Type 2 Diabetes Mellitus, Infant, General Medicine, medicine.disease, Prognosis, Confidence interval, Diabetes Mellitus, Type 1, Child, Preschool, Age differences, Female, business, Serbia, Demography, Research Article, Follow-Up Studies

الوصف: Background The incidence of type 1 diabetes mellitus (T1DM) increased worldwide. The objective of the paper was to compare the incidence trend of T1DM in children and adolescents aged 0–19 and in adults under 30 years of age in Serbia from 2006 to 2017. Additional aim was to compare incidence rates of T1DM and type 2 diabetes mellitus (T2DM) among adults aged 20–24 and 25–29 years of age. Methods Trends and annual percentage change (APC) of the incidence rate with corresponding 95% confidence intervals (CI) were calculated by Joinpoint Regression Analyses. Results We found a significant increase of incidence in children aged 5–9 with the APC of 5.7% (95%CI: 2.3–9.1), and in children aged 10–14 with the APC of 2.1% (95%CI: 0.6–3.6). A significant decrease of incidence was determined in adolescents aged 15–19 with the APC -4.9% (95%CI: − 8.9 to – 0.7) and in adults aged 25–29 with the APC -7.3% (95%CI: − 12.5 to − 1.8). Conclusion The increase of incidence in children aged 0–14 and its decrease after 15 years of age showed that T1DM is predominantly a metabolic disease of children in Serbia. A significant increase in incidence was recorded in two age groups, namely 5–9 and 10–14 years of age. The highest increase was in children aged 5–9 and the highest incidence rate was in children aged 10–14. An insignificant increasing of T2DM incidence was observed in young adults aged 25–29. The increase in incidence rates in children, but not in young adults, suggests that the precipitating factors of children-onset disease may differ from those of adult-onset T1DM.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05bcfe8537a716a8768a01c8e565ab34Test
http://link.springer.com/article/10.1186/s12902-020-0504-yTest

المؤلفون: Lulu Zhou, Xueqiong Zhu, Haiyan Zhu, Xuejiao Tao, Bo Sheng, Xuejie Zhu

المصدر: BMC Cancer, Vol 19, Iss 1, Pp 1-9 (2019)
BMC Cancer

مصطلحات موضوعية: 0301 basic medicine, Male, Cancer Research, medicine.medical_treatment, Uterine Cervical Neoplasms, Peroxiredoxin 1, Peroxiredoxin 2, 0302 clinical medicine, Thioredoxins, Surgical oncology, Medicine, Cervical cancer, Cervical squamous cancer, Middle Aged, respiratory system, Prognosis, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Neoadjuvant Therapy, Up-Regulation, Gene Expression Regulation, Neoplastic, Treatment Outcome, Oncology, 030220 oncology & carcinogenesis, Carcinoma, Squamous Cell, Immunohistochemistry, Female, medicine.drug, Research Article, Adult, Antineoplastic Agents, Neoadjuvant chemotherapy, lcsh:RC254-282, Thioredoxin 1, 03 medical and health sciences, Genetics, Humans, Aged, Cisplatin, Chemotherapy, business.industry, Peroxiredoxins, medicine.disease, Survival Analysis, Squamous carcinoma, 030104 developmental biology, Case-Control Studies, Cancer research, business

الوصف: Background This study aims to investigate the expression of thioredoxin 1, peroxiredoxin 1 and peroxiredoxin 2 in bulky cervical squamous carcinoma and its predictive role in cisplatin-based neoadjuvant chemotherapy. Methods Initially, the expression of thioredoxin 1, peroxiredoxin 1 and peroxiredoxin 2 protein was analyzed in 13 human cervical squamous cancer tissues and their paired adjacent non-cancerous tissues by western-blotting and immunohistochemistry. Then, correlation between the expression of thioredoxin 1, peroxiredoxin 1, peroxiredoxin 2 and responses to cisplatin-based neoadjuvant chemotherapy was analyzed in 35 paired tumor samples (pre- and post-chemotherapy) from bulky cervical squamous cancer patients by immunohistochemistry. Results A clinical response occurred in 48.6% (17/35) of patients, including 14.3% (5/35) with a complete response and 34.3% (12/35) with a partial response. The expression of thioredoxin 1, peroxiredoxin 1 and peroxiredoxin 2 was much higher in cervical squamous cancer tissues compared with paired adjacent non-cancerous tissues by western-blotting and immunohistochemistry. Additionally, the expression of thioredoxin 1, peroxiredoxin 1 and peroxiredoxin 2 was significantly up-regulated in post-chemotherapy tissues compared to pre-chemotherapy cervical cancer tissues. High levels of thioredoxin 1, peroxiredoxin 1 and peroxiredoxin 2 were associated with a poor chemotherapy response in cervical squamous cancer patients. Conclusions Thioredoxin 1, peroxiredoxin 1 and peroxiredoxin 2 are frequently over-expressed in cervical squamous cancer. High expression levels of these proteins were related to a poor response to cisplatin-based neoadjuvant chemotherapy. The present study is the first report that thioredoxin peroxidase system may serve as a prediction of the responses to neoadjuvant chemotherapy in cervical squamous cancer.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18c9e930a64c2aa54ce13a67a5d54566Test
http://link.springer.com/article/10.1186/s12885-019-6046-xTest

المؤلفون: Xianshang Zeng, Guixing Xu, Qilong Liu, Huanyi Lin, Weiguang Yu

المصدر: BMC Cancer, Vol 21, Iss 1, Pp 1-11 (2021)
BMC Cancer

مصطلحات موضوعية: Male, Cancer Research, Survival, Programmed Cell Death 1 Receptor, Kaplan-Meier Estimate, Pembrolizumab, Gastroenterology, Prostate cancer, chemistry.chemical_compound, Antineoplastic Agents, Immunological, 0302 clinical medicine, Surgical oncology, Antineoplastic Combined Chemotherapy Protocols, Molecular Targeted Therapy, 030212 general & internal medicine, Castration-resistant, RC254-282, Aged, 80 and over, Hazard ratio, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Middle Aged, Prognosis, Immunohistochemistry, Prostatic Neoplasms, Castration-Resistant, Treatment Outcome, Oncology, 030220 oncology & carcinogenesis, Benzamides, Research Article, Adult, medicine.medical_specialty, Antibodies, Monoclonal, Humanized, 03 medical and health sciences, Internal medicine, Nitriles, Phenylthiohydantoin, Biomarkers, Tumor, Genetics, medicine, Enzalutamide, Humans, Adverse effect, Aged, Neoplasm Staging, Retrospective Studies, business.industry, Retrospective cohort study, medicine.disease, Confidence interval, chemistry, business

الوصف: BackgroundThe purpose of this retrospective study was to evaluate the survival outcomes of pembrolizumab (PEM) plus enzalutamide (ENZ) versus PEM alone in selected populations of men with previously untreated metastatic castration-resistant prostate cancer (mCRPC) harbouring programmed cell death ligand-1 (PD-L1) staining.MethodsConsecutive men with previously untreated mCRPC harbouring PD-L1 staining who underwent treatment with PEM plus ENZ (PE) or PEM alone (PA) at our medical centre from January 1, 2017, to January 31, 2021, were retrospectively identified. Follow-up was conducted monthly during the first year and then every 1 month thereafter. The primary outcomes of the study were overall survival (OS) and progression-free survival (PFS). Secondary outcomes were the frequency of key adverse events (AEs).ResultsIn total, 302 men were retrospectively reviewed, 96 of whom were deemed to be ineligible per the exclusion criteria, leaving 206 men (PE:n = 100, median age 64 years [range, 43–85] and PA:n = 106, 65 years [range, 45–82]) who were eligible for the study. The median follow-up for both groups was 34 months (range, 2–42). At the final follow-up, the median OS was 25.1 months (95% confidence interval [CI], 22.3–27.6) in the PE group versus 18.3 months (95% CI, 16.5–20.9) in the PA group (hazard ratio [HR] 0.56; 95% CI, 0.39–0.80;p = 0.001). A marked distinction was also observed in the median PFS (6.1 months [95% CI, 4.7–7.8] for PE vs. 4.9 months for PA (95% CI, 3.2–6.4) for PA; HR 0.55, 95% CI, 0.41–0.75;p = 0.001). There were noteworthy differences in the rate of the key AEs between the two groups (72.0% for PE vs. 45.3% for PA,p p = 0.025) and musculoskeletal events (9.0% for PE vs. 0.9% for PA,p = 0.007), but these events tended to be manageable.ConclusionsAmong selected populations of men with previously untreated mCRPC harbouring PD-L1 staining, PEM added to ENZ treatment may significantly increase the survival benefits compared with PEM treatment alone regardless of tumor mutation status. The safety profile for PE plus ENZ tends to be manageable.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::286a82d108207695d015571f473b3f5dTest
https://doaj.org/article/bc67f9ef33a1424aab1f39fb6847c9d2Test

المؤلفون: Baihai Su, Yuxuan Qiu, Zheng Qin, Jiwen Geng

المصدر: Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-13 (2021)
Journal of Translational Medicine

مصطلحات موضوعية: Adult, medicine.medical_specialty, Urinary system, 030232 urology & nephrology, lcsh:Medicine, Subgroup analysis, Kidney injury molecule 1, Review, 030204 cardiovascular system & hematology, Kidney, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, 0302 clinical medicine, AKI, Internal medicine, Medicine, Humans, KIM-1, business.industry, lcsh:R, Area under the curve, Acute kidney injury, Bayes Theorem, General Medicine, medicine.disease, Prognosis, Clinical trial, Meta-analysis, Diagnostic odds ratio, Systematic review, business, Biomarkers

الوصف: IntroductionThe aim of the study was to systematically review relevant studies to evaluate the diagnostic value of urinary kidney injury molecule 1 (uKIM-1) for acute kidney injury (AKI) in adults.MethodWe searched PubMed and Embase for literature published up to November 1st, 2019 and used the Quality Assessment Tool for Diagnosis Accuracy Studies (QUADAS-2) to assess the quality. Then, we extracted useful information from each eligible study and pooled sensitivity, specificity, and area under the curve (AUC) values.ResultsA total of 14 studies with 3300 patients were included. The estimated sensitivity of urinary KIM-1 (uKIM-1) in the diagnosis of AKI was 0.74 (95% CrI 0.62–0.84), and the specificity was 0.84 (95% CrI, 0.76–0.90). The pooled diagnostic odds ratio (DOR) was 15.22 (95% CrI, 6.74–42.20), the RD was 0.55 (95% CrI 0.43–0.70), and the AUC of uKIM-1 in diagnosing AKI was 0.62 (95% CrI 0.41–0.76). The results of the subgroup analysis showed the influence of different factors.ConclusionUrinary KIM-1 is a good predictor for AKI in adult patients with relatively high sensitivity and specificity. However, further research and clinical trials are still needed to confirm whether and how uKIM-1 can be commonly used in clinical diagnosis.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1a4c54bcba9a18c8785f049c541e831Test
https://doaj.org/article/1a0331dc43c843ae818b77c91a73fc6eTest

المؤلفون: Mitsugu Sekimoto, Tomoharu Sugie, Hirotsugu Yanai, Katsuhiro Yoshikawa, Koji Tsuta, Mitsuaki Ishida

المصدر: BMC Cancer, Vol 21, Iss 1, Pp 1-10 (2021)
BMC Cancer

مصطلحات موضوعية: Adult, 0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, Triple Negative Breast Neoplasms, lcsh:RC254-282, B7-H1 Antigen, Disease-Free Survival, PD-L1 Positive, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Triple-negative breast cancer, Surgical oncology, Internal medicine, Tumor Microenvironment, Genetics, medicine, Humans, Overall survival, Breast, Programmed death ligand 1, Mastectomy, Cancer-associated fibroblasts, Aged, Retrospective Studies, Aged, 80 and over, Tissue microarray, business.industry, Hazard ratio, Middle Aged, Prognosis, medicine.disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, 030104 developmental biology, Chemotherapy, Adjuvant, 030220 oncology & carcinogenesis, Immunohistochemistry, Female, Neoplasm Recurrence, Local, business, Immunostaining, Research Article

الوصف: Background Cancer-associated fibroblasts (CAFs) are some of the most abundant components of the tumour microenvironment. A recent study suggested that in some cancers, CAFs express programmed death ligand 1 (PD-L1), which can act as a prognostic marker. The aim of this study was to investigate the clinicopathological significance of CAF PD-L1 expression in patients with triple-negative breast cancer (TNBC) and to identify the most suitable primary antibody for immunostaining for CAF PD-L1. Methods Immunohistochemical staining (primary antibodies of 73–10, SP142, and E1L3N) and tissue microarrays were used to analyse the expression profiles of PD-L1 in CAF in 61 patients with TNBC who underwent surgery. Overall survival (OS) was compared based on CAF PD-L1 expression, and the risk factors for OS were analysed. The relationship between clinicopathological parameters and survival was also examined. Results Thirty-four (55.7%) patients were positive for CAF PD-L1 (73–10) expression. Compared with CAF PD-L1 negativity, there was a significant correlation between CAF PD-L1 positivity and better OS (p = 0.029). CAF PD-L1 expression, evaluated using SP-142 or E1L3N, did not correlate with OS. CAF PD-L1-positivity (73–10) correlated significantly with better prognosis in multivariate analyses (hazard ratio: 0.198; 95% confidence interval: 0.044–0.891; p = 0.035). Conclusions CAF PD-L1 expression is a novel marker for a better prognosis of patients with TNBC, and the 73–10 assay may be suitable for immunostaining CAF PD-L1.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec2435406852a1a4c4bb7d79e5cd9a15Test
https://doaj.org/article/bf387e4ac97042ff936efbd811da52c0Test