Modulation of atypical brain activation during executive functioning in autism: a pharmacological MRI study of tianeptine
| العنوان: | Modulation of atypical brain activation during executive functioning in autism: a pharmacological MRI study of tianeptine |
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| المؤلفون: | Eileen Daly, Grainne M. McAlonan, Dene Robertson, Vladimira Stoencheva, Katya Rubia, Clodagh M. Murphy, Vincent Giampietro, Robert Wichers, Declan G. Murphy, James Findon, Auke Jelsma, Christine Ecker, Sarah H. Blainey |
| المساهمون: | VU University medical center |
| المصدر: | Molecular Autism, Vol 12, Iss 1, Pp 1-13 (2021) Wichers, R H, Findon, J L, Jelsma, A, Giampietro, V, Stoencheva, V, Robertson, D M, Murphy, C M, Blainey, S, McAlonan, G, Ecker, C, Rubia, K, Murphy, D G M & Daly, E M 2021, ' Modulation of atypical brain activation during executive functioning in autism: a pharmacological MRI study of tianeptine ', Molecular autism, vol. 12, no. 1, 14 . https://doi.org/10.1186/s13229-021-00422-0Test Molecular Autism Molecular autism, 12(1):14. SAGE Publications Ltd |
| بيانات النشر: | BMC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Serotonin, Neurology, genetic structures, Thiazepines, Pilot Projects, Antidepressive Agents, Tricyclic, Serotonergic, behavioral disciplines and activities, lcsh:RC346-429, 03 medical and health sciences, Executive Function, Young Adult, 0302 clinical medicine, Developmental Neuroscience, Double-Blind Method, medicine, Humans, Tianeptine, Attention, Autistic Disorder, Autism spectrum disorder, Molecular Biology, lcsh:Neurology. Diseases of the nervous system, Temporal cortex, Cross-Over Studies, Research, fMRI, Neuropsychology, Brain, Middle Aged, medicine.disease, Magnetic Resonance Imaging, 030227 psychiatry, Psychiatry and Mental health, Autism, Executive functioning, Neuroscience, 030217 neurology & neurosurgery, Neurotypical, Developmental Biology, medicine.drug |
| الوصف: | Background Autism spectrum disorder (ASD) is associated with deficits in executive functioning (EF), and these have been suggested to contribute to core as well as co-occurring psychiatric symptoms. The biological basis of these deficits is unknown but may include the serotonergic system, which is involved both in regulating EF in neurotypical populations and in the pathophysiology of ASD. We previously demonstrated that reducing serotonin by acute tryptophan depletion (ATD) shifts differences in brain function during performance of EF tasks towards control levels. However, ATD cannot be easily used in the clinic, and we therefore need to adopt alternative approaches to challenge the serotonin system. Hence, we investigated the role of the serotonergic modulator tianeptine on EF networks in ASD. Method We conducted a pharmacological magnetic resonance imaging study, using a randomized double-blind crossover design, to compare the effect of an acute dosage of 12.5 mg tianeptine and placebo on brain activation during two EF tasks (of response inhibition and sustained attention) in 38 adult males: 19 with ASD and 19 matched controls. Results Under placebo, compared to controls, individuals with ASD had atypical brain activation in response inhibition regions including the inferior frontal cortex, premotor regions and cerebellum. During sustained attention, individuals with ASD had decreased brain activation in the right middle temporal cortex, right cuneus and left precuneus. Most of the case–control differences in brain function observed under placebo conditions were abolished by tianeptine administration. Also, within ASD individuals, brain functional differences were shifted significantly towards control levels during response inhibition in the inferior frontal and premotor cortices. Limitations We conducted a pilot study using a single dose of tianeptine, and therefore, we cannot comment on long-term outcome. Conclusions Our findings provide the first evidence that tianeptine can shift atypical brain activation during EF in adults with ASD towards control levels. Future studies should investigate whether this shift in the biology of ASD is maintained after prolonged treatment with tianeptine and whether it improves clinical symptoms. |
| اللغة: | English |
| تدمد: | 2040-2392 1362-3613 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbaf26b138687ad52f41b31d1520d047Test https://doaj.org/article/85fb0095033640018ef35a6ff71ea754Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....dbaf26b138687ad52f41b31d1520d047 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20402392 13623613 |
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