المؤلفون: Li Xu, Xinchun Yang, Peijia Wang, Jie Wei, Yuxia Pan, Yuanfeng Gao, Mulei Chen, Wenkai Liao

المصدر: BMC Cardiovascular Disorders, Vol 21, Iss 1, Pp 1-7 (2021)
BMC Cardiovascular Disorders

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, medicine.medical_treatment, Myocardial Infarction, Acute myocardial infarction, Risk Assessment, Thrombospondin 1, Young Adult, Predictive Value of Tests, Risk Factors, Internal medicine, Tachycardia, Supraventricular, medicine, Humans, Diseases of the circulatory (Cardiovascular) system, Myocardial infarction, cardiovascular diseases, Atrial tachycardia, Aged, Angiology, business.industry, Atrial arrhythmias, Research, Percutaneous coronary intervention, Atrial fibrillation, Middle Aged, medicine.disease, Up-Regulation, Cardiac surgery, Atrial Flutter, RC666-701, Cardiology, cardiovascular system, Female, Atrial Premature Complexes, medicine.symptom, Cardiology and Cardiovascular Medicine, business, Atrial remodeling, Biomarkers, Atrial flutter, Thrombospondin-1

الوصف: Objectives Atrial remodeling is the main developmental cause of atrial arrhythmias (AA), which may induce atrial fibrillation, atrial flutter, atrial tachycardia, and frequent premature atrial beats in acute myocardial infarction (AMI) patients. Thrombospondin-1 (TSP-1) has been shown to play an important role in inflammatory and fibrotic processes, but its role in atrial arrhythmias is not well described. The purpose of this study was to investigate the role of TSP-1 in AMI patients with atrial arrhythmias. Methods A total of 219 patients with AMI who underwent percutaneous coronary intervention and with no previous arrhythmias were included. TSP-1 were analyzed in plasma samples. Patients were classified into 2 groups, namely, with and without AA during the acute phase of MI. Continuous electrocardiographic monitoring was used for AA diagnosis in hospital. Results Twenty-four patients developed AA. Patients with AA had higher TSP-1 levels (29.01 ± 25.87 μg/mL vs 18.36 ± 10.89 μg/mL, p p p p = 0.034), Hs-CRP (OR 1.023; 95% CI 1.006–1.041, p = 0.008), age (OR 1.067; 95% CI 1.004–1.135, p = 0.038) and LVDd (OR 1.142; 95% CI 1.018–1.282, p = 0.024) emerged as independent risk factors for AA in AMI patients. Conclusion TSP-1 is a potential novel indicator of atrial arrhythmias during AMI. Graphical abstract

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c276ecfb1cc2a5c667b562f21ad7d3bTest
https://doaj.org/article/9714c38885a046f6b9cf5c1a816f4ccfTest

المؤلفون: Hilde Bastiaens, Rawlance Ndejjo, Geofrey Musinguzi, Fred Nuwaha, Rhoda K. Wanyenze

المصدر: BMC Public Health, Vol 20, Iss 1, Pp 1-9 (2020)
BMC Public Health
BMC public health

مصطلحات موضوعية: Male, Health Knowledge, Attitudes, Practice, Psychological intervention, Disease, 030204 cardiovascular system & hematology, 0302 clinical medicine, Risk Factors, Surveys and Questionnaires, Epidemiology, Uganda, 030212 general & internal medicine, 2. Zero hunger, education.field_of_study, lcsh:Public aspects of medicine, 1. No poverty, Middle Aged, 3. Good health, Cardiovascular Diseases, Hypertension, symbols, Educational Status, Female, medicine.symptom, Diet, Healthy, Research Article, Adult, medicine.medical_specialty, Population, Physical activity and sub-Saharan Africa, Asymptomatic, 03 medical and health sciences, symbols.namesake, Environmental health, medicine, Humans, Poisson regression, Healthy Lifestyle, education, Exercise, Aged, business.industry, Public health, Public Health, Environmental and Occupational Health, lcsh:RA1-1270, Diet, Cross-Sectional Studies, Socioeconomic Factors, Human medicine, Biostatistics, business, Healthy lifestyles, Cell Phone

الوصف: Background With the growing epidemic of Cardiovascular Disease (CVD) in sub-Saharan Africa, behavioural change interventions are critical in supporting populations to achieve better cardiovascular health. Population knowledge regarding CVD is an important first step for any such interventions. This study examined CVD prevention knowledge and associated factors among adults in Mukono and Buikwe districts in Uganda. Methods The study was cross-sectional in design conducted among adults aged 25 to 70 years as part of the baseline assessment by the Scaling-up Packages of Interventions for Cardiovascular disease prevention in selected sites in Europe and Sub-Saharan Africa (SPICES) – project. Data were collected using pretested semi-structured questionnaires, and respondents categorized as knowledgeable if they scored at least five out of six in the knowledge questions. Data were exported into STATA version 15.0 statistical software for analysis conducted using mixed-effects Poisson regression with fixed and random effects and robust standard errors. Results Among the 4372 study respondents, only 776 (17.7%) were knowledgeable on CVD prevention. Most respondents were knowledgeable about foods high in calories 2981 (68.2%), 2892 (66.1%) low fruit and vegetable intake and high salt consumption 2752 (62.9%) as CVD risk factors. However, majority 3325 (76.1%) thought the recommended weekly moderate physical activity was 30 min and half 2262 (51.7%) disagreed or did not know that it was possible to have hypertension without any symptoms. Factors associated with high CVD knowledge were: post-primary education [APR = 1.55 (95% CI: 1.18–2.02), p = 0.002], formal employment [APR = 1.69 (95% CI: 1.40–2.06), p p = 0.004]. Other factors were: household ownership of a mobile phone [APR = 1.35 (95% CI: 1.07–1.70), p = 0.012] and ever receiving advice on healthy lifestyles [APR = 1.38 (95% CI: 1.15–1.67), p = 0.001]. Conclusions This study found very low CVD knowledge with major gaps around recommended physical activity duration, diet and whether hypertension is asymptomatic. Observed knowledge gaps should inform suitable interventions and strategies to equip and empower communities with sufficient information for CVD prevention. Trial registration ISRCTN Registry ISRCTN15848572, January 2019, retrospectively registered.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e44debd369e57eac0e4cccdcff61fb63Test
http://link.springer.com/article/10.1186/s12889-020-09264-6Test

المؤلفون: Cécile Delcourt, Catherine Helmer, Kalina Rajaobelina, C. Blanc-Bisson, Fritz-Line Vélayoudom-Céphise, Vincent Rigalleau, Laurence Blanco, Laure Alexandre, Kamel Mohammedi, Marie Monlun, Audrey Cougnard-Gregoire

المصدر: Cardiovascular Diabetology, Vol 17, Iss 1, Pp 1-7 (2018)
Cardiovascular Diabetology

مصطلحات موضوعية: Adult, Glycation End Products, Advanced, Male, medicine.medical_specialty, lcsh:Diseases of the circulatory (Cardiovascular) system, Time Factors, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, 030209 endocrinology & metabolism, 030204 cardiovascular system & hematology, Revascularization, 03 medical and health sciences, Skin autofluorescence, 0302 clinical medicine, Predictive Value of Tests, Risk Factors, Internal medicine, Diabetes mellitus, medicine, Humans, Macroangiopathy, Myocardial infarction, cardiovascular diseases, Advanced glycation end-products, Stroke, Original Investigation, Aged, Skin, Angiology, 2. Zero hunger, Type 1 diabetes, business.industry, Middle Aged, Prognosis, medicine.disease, 3. Good health, Diabetes Mellitus, Type 1, Cardiovascular Diseases, lcsh:RC666-701, Luminescent Measurements, Female, Cardiology and Cardiovascular Medicine, business, Body mass index, Biomarkers, Mace, Follow-Up Studies

الوصف: Background Advanced glycation end-products play a role in diabetic vascular complications. Their optical properties allow to estimate their accumulation in tissues by measuring the skin autofluorescence (SAF). We searched for an association between SAF and major adverse cardiovascular events (MACE) incidence in subjects with Type 1 Diabetes (T1D) during a 7 year follow-up. Methods During year 2009, 232 subjects with T1D were included. SAF measurement, clinical [age, sex, body mass index (BMI), comorbidities] and biological data (HbA1C, blood lipids, renal parameters) were recorded. MACE (myocardial infarction, stroke, lower extremity amputation or a revascularization procedure) were registered at visits in the center or by phone call to general practitioners until 2016. Results The participants were mainly men (59.5%), 51.5 ± 16.7 years old, with BMI 25.0 ± 4.1 kg/m2, diabetes duration 21.5 ± 13.6 years, HbA1C 7.6 ± 1.1%. LDL cholesterol was 1.04 ± 0.29 g/L, estimated Glomerular Filtration Rates (CKD-EPI): 86.3 ± 26.6 ml/min/1.73 m2. Among these subjects, 25.1% were smokers, 45.3% had arterial hypertension, 15.9% had elevated AER (≥ 30 mg/24 h), and 9.9% subjects had a history of previous MACE. From 2009 to 2016, 22 patients had at least one new MACE: 6 myocardial infarctions, 1 lower limb amputation, 15 revascularization procedures. Their SAF was 2.63 ± 0.73 arbitrary units (AU) vs 2.08 ± 0.54 for other patients (p = 0.002). Using Cox-model, after adjustment for age (as the scale time), sex, diabetes duration, BMI, hypertension, smoking status, albumin excretion rates, statin treatment and a previous history of MACE, higher baseline levels of SAF were significantly associated with an increased risk of MACE during follow-up (HR = 4.13 [1.30–13.07]; p = 0.02 for 1 AU of SAF) and Kaplan–Meier curve follow-up showed significantly more frequent MACE in group with SAF upper the median (p = 0.001). Conclusion A high SAF predicts MACE in patients with T1D. Electronic supplementary material The online version of this article (10.1186/s12933-018-0718-8) contains supplementary material, which is available to authorized users.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f2c41cfbef7737659ed9004eaebbbbcTest
http://link.springer.com/article/10.1186/s12933-018-0718-8Test

المؤلفون: Bernard Zinman, Chang Ye, Anthony J. Hanley, Philip W. Connelly, Sadia Mehmood, Ravi Retnakaran

المصدر: Cardiovascular Diabetology, Vol 17, Iss 1, Pp 1-9 (2018)
Cardiovascular Diabetology

مصطلحات موضوعية: Blood Glucose, lcsh:Diseases of the circulatory (Cardiovascular) system, Time Factors, endocrine system diseases, Endocrinology, Diabetes and Metabolism, Type 2 diabetes, 030204 cardiovascular system & hematology, RBP-4, Impaired glucose tolerance, 0302 clinical medicine, Pregnancy, Risk Factors, Medicine, Prospective Studies, Gestational diabetes, Original Investigation, biology, Obstetrics, 3. Good health, Up-Regulation, Cardiovascular Diseases, Biomarker (medicine), Female, Chemerin, Adiponectin, Cardiology and Cardiovascular Medicine, CRP, Adult, medicine.medical_specialty, Down-Regulation, 030209 endocrinology & metabolism, Plasminogen activator inhibitor-1, 03 medical and health sciences, Diabetes mellitus, Internal medicine, Plasminogen Activator Inhibitor 1, Humans, business.industry, nutritional and metabolic diseases, medicine.disease, Diabetes, Gestational, lcsh:RC666-701, biology.protein, business, Biomarkers, Metabolism, Inborn Errors

الوصف: Background Gestational diabetes (GDM) and milder gestational impaired glucose tolerance (GIGT) identify women at risk of developing type 2 diabetes and cardiovascular disease later in life. Accordingly, the postpartum years after gestational dysglycemia can provide insight into early events in the natural history of these disorders. We thus sought to prospectively evaluate the relationship between gestational glucose tolerance and emerging cardiometabolic biomarkers [adiponectin, chemerin, retinol-binding protein-4 (RBP-4), C-reactive protein (CRP), plasminogen activator inhibitor-1 (PAI-1)] at both 1- and 3-years postpartum in a cohort reflecting the full spectrum of gestational dysglycemia (from normal to GIGT to GDM). Methods Three-hundred-and-thirty-nine women completed a glucose challenge test (GCT) and oral glucose tolerance test (OGTT) in pregnancy, which identified 4 gestational glucose tolerance groups: GDM (n = 105); GIGT (n = 59); abnormal GCT with normal OGTT (n = 99); and normal GCT with normal OGTT (n = 76). At 1- and 3-years postpartum, the women underwent repeat OGTT with measurement of biomarkers (adiponectin/chemerin/RBP-4/CRP/PAI-1). Results Serum adiponectin was lower in women with GDM and GIGT at both 1-year and 3-years (both P ≤ 0.002), whereas chemerin, RBP-4, CRP and PAI-1 showed no differences across the 4 groups. Importantly, the change in PAI-1 between 1- and 3-years progressively increased from the normal GCT group to the abnormal GCT group to GIGT to GDM (P = 0.03). Indeed, both GDM (t = 2.98, P = 0.003) and GIGT (t = 2.14, P = 0.03) independently predicted an increase in PAI-1 from 1- to 3-years postpartum. Conclusions Hypoadiponectinemia and rising PAI-1 over time are early features of the cardiometabolic biomarker profile of women with recent gestational dysglycemia. Electronic supplementary material The online version of this article (10.1186/s12933-018-0776-y) contains supplementary material, which is available to authorized users.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8fe94f6d612fc50a95e86b5d6c1f30aTest
http://link.springer.com/article/10.1186/s12933-018-0776-yTest

المؤلفون: Andrew Calzavara, James Lachaud, Peter Donnelly, David Henry, Laura C. Rosella, Catherine Bornbaum, Kathy Kornas

المساهمون: University of St Andrews. Institute for Capitalising on Creativity, University of St Andrews. School of Medicine, University of St Andrews. WHO Collaborating Centre for International Child & Adolescent Health Policy

المصدر: International Journal for Equity in Health, Vol 16, Iss 1, Pp 1-7 (2017)
International Journal for Equity in Health

مصطلحات موضوعية: Male, Life expectancy, Poison control, HV, 0302 clinical medicine, RA0421, Homicide, Residence Characteristics, Risk Factors, RA0421 Public health. Hygiene. Preventive Medicine, Neoplasms, HV Social pathology. Social and public welfare, 030212 general & internal medicine, Middle aged, Child, Ontario, education.field_of_study, Homicide/statistics & numerical data, Health Policy, lcsh:Public aspects of medicine, 1. No poverty, Ontario/epidemiology, Middle Aged, 16. Peace & justice, 3. Good health, Geography, Cardiovascular Diseases, Child, Preschool, Socioeconomic status, Potential years of life lost, Female, Neoplasms/mortality, 0305 other medical science, Adult, medicine.medical_specialty, Canada, Child, preschool, Adolescent, Population, Population health, Death Certificates, 03 medical and health sciences, Young Adult, Life Expectancy, SDG 3 - Good Health and Well-being, Injury prevention, medicine, Humans, Social determinants of health, education, Aged, 030505 public health, Death certificates, Public health, Research, SDG 16 - Peace, Justice and Strong Institutions, Public Health, Environmental and Occupational Health, DAS, lcsh:RA1-1270, Social class, Cardiovascular diseases/mortality, Young adult, Years of potential life lost, Risk factors, Social Class, Residence characteristics/statistics & numerical data, Demography

الوصف: Funding: This study was funded by a Canadian Institutes for Health Research Operating Grant (FRN-142498). LR is supported by a Canada Research Chair in Population Health Analytics. Background: Homicide - a lethal expression of violence - has garnered little attention from public health researchers and health policy makers, despite the fact that homicides are a cause of preventable and premature death. Identifying populations at risk and the upstream determinants of homicide are important for addressing inequalities that hinder population health. This population-based study investigates the public health significance of homicides in Ontario, Canada, over the period of 1999-2012. We quantified the relative burden of homicides by comparing the socioeconomic gradient in homicides with the leading causes of death, cardiovascular disease (CVD) and neoplasm, and estimated the potential years of life lost (PYLL) due to homicide. Methods: We linked vital statistics from the Office of the Registrar General Deaths register (ORG-D) with Census and administrative data for all Ontario residents. We extracted all homicide, neoplasm, and cardiovascular deaths from 1999 to 2012, using International Classification of Diseases codes. For socioeconomic status (SES), we used two dimensions of the Ontario Marginalization Index (ON-Marg): material deprivation and residential instability. Trends were summarized across deprivation indices using age-specific rates, rate ratios, and PYLL. Results: Young males, 15-29 years old, were the main victims of homicide with a rate of 3.85 [IC 95%: 3.56; 4.13] per 100,000 population and experienced an upward trend over the study period. The socioeconomic neighbourhood gradient was substantial and higher than the gradient for both cardiovascular and neoplasms. Finally, the PYLL due to homicide were 63,512 and 24,066 years for males and females, respectively. Conclusions: Homicides are an important cause of death among young males, and populations living in disadvantaged neighbourhoods. Our findings raise concerns about the burden of homicides in the Canadian population and the importance of addressing social determinants to address these premature deaths. Publisher PDF

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::745c3be631b37c3b391fa37733f356afTest
http://link.springer.com/article/10.1186/s12939-017-0632-9Test

المؤلفون: Eva Králíková, Hana Ross, Narine Movsisyan, Ondrej Sochor, Renata Cifkova, Francisco Lopez-Jimenez

المصدر: BMC Public Health, Vol 16, Iss 1, Pp 1-10 (2016)
BMC Public Health

مصطلحات موضوعية: Adult, Male, Urban Population, Cross-sectional study, medicine.medical_treatment, Population, Central and Eastern Europe, 030204 cardiovascular system & hematology, Smoking cessation, Odds, 03 medical and health sciences, Sex Factors, 0302 clinical medicine, Risk Factors, Environmental health, Tobacco, Prevalence, Humans, Medicine, 030212 general & internal medicine, 10. No inequality, education, Socioeconomic status, Czech Republic, education.field_of_study, business.industry, lcsh:Public aspects of medicine, Smoking, Tobacco control, Age Factors, 1. No poverty, Public Health, Environmental and Occupational Health, lcsh:RA1-1270, Middle Aged, 3. Good health, Cross-Sectional Studies, Socioeconomic Factors, Cardiovascular Diseases, Cross-sectional survey, 8. Economic growth, Marital status, Female, Biostatistics, Inequalities, business, Research Article

الوصف: Background Many studies have examined the socioeconomic variations in smoking and quitting rates across the European region; however, data from Central and East European countries, where the tobacco burden is especially high, are sparse. This study aimed to assess the patterns in current and past smoking prevalence based on cross-sectional data from a Central European urban population sample. Methods Data from 2160 respondents aged 25–64 years in Brno, Czech Republic were collected in 2013–2014 using the Czech post-MONICA survey questionnaire to assess the prevalence of cardiovascular risk factors, including smoking status. The age- and sex-stratified randomized sample was drawn using health insurance registries. Descriptive statistics and quit ratios were calculated, and chi-square and multivariate logistic analyses conducted to examine relationships between current and past smoking and demographic (age, gender, marital status) and socioeconomic variables (education, income, occupation). Results The prevalence of current and past smoking was 23.6 and 31.3 % among men and 20.5 and 23.2 % among women, respectively. Education reliably predicted smoking and quitting rates in both genders. Among men, being unemployed was associated with greater odds of smoking (OR 3.6; 1.6–8.1) and lower likelihood of quitting (OR 0.2: 0.1–0.6); the likelihood of quitting also increased with age (OR 1.8; 1.2–2.8). Among women, marital status (being married) decreased the odds of current smoking (OR 0.6; 0.4–0.9) and increased the odds of quitting (OR 2.2; 1.2–3.9). Quit ratios were the lowest in the youngest age group (25–34 years) where quitting was more strongly associated with middle income (OR 2.7; 95 % CI 1.2–5.9) than with higher education (OR 2.9; 95 % CI 0.9–8.2). Conclusions Interventions to increase cessation rates and reduce smoking prevalence need to be gender-specific and carefully tailored to the needs of the disadvantaged groups of the population, especially the less well-off young adults. Future studies should examine the equity impact of the tobacco control policies and be inclusive of the Central and East European countries.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c874c69b28e6dd9e23e86dd05944627Test
http://link.springer.com/article/10.1186/s12889-016-3216-5Test

المؤلفون: Fernando Ma Giuffrida, Eloa R. Rocco, Carlos Antonio Negrato, Sergio Atala Dib, Denise Barretto Mory, Roberta A Cobas, Reine M Chaves-Fonseca, Odelisa S Matos, Patricia Dualib, Marília B. Gomes, Alexis D Guedes

المصدر: Cardiovascular Diabetology, Vol 11, Iss 1, p 156 (2012)
Cardiovascular Diabetology

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, lcsh:Diseases of the circulatory (Cardiovascular) system, endocrine system diseases, Adolescent, Cross-sectional study, Endocrinology, Diabetes and Metabolism, Type 2 diabetes, Disease cluster, Cardiovascular risk factor, Young Adult, Risk Factors, Internal medicine, Diabetes mellitus, medicine, Humans, Original Investigation, Dyslipidemias, Glycated Hemoglobin, Type 1 diabetes, business.industry, Case-control study, nutritional and metabolic diseases, medicine.disease, Lipids, Metabolic syndrome, Cross-Sectional Studies, Diabetes Mellitus, Type 1, Dyslipidemia, Cardiovascular Diseases, lcsh:RC666-701, Case-Control Studies, lipids (amino acids, peptides, and proteins), Female, Cardiology and Cardiovascular Medicine, business, Brazil

الوصف: Background Cardiovascular risk factors (CVRF) may cluster in type 1 diabetes, analogously to the metabolic syndrome described in type 2 diabetes. The threshold of HbA1c above which lipid variables start changing behavior is unclear. This study aims to 1) assess the behavior of dyslipidemia according to HbA1c values; 2) detect a threshold of HbA1c beyond which lipids start to change and 3) compare the clustering of lipids and other non-lipid CVRF among strata of HbA1c individuals with type 1 diabetes. Methods Effects of HbA1c quintiles (1st: ≤7.4%; 2nd: 7.5-8.5%; 3rd: 8.6-9.6%; 4th: 9.7-11.3%; and 5th: >11.5%) and covariates (gender, BMI, blood pressure, insulin daily dose, lipids, statin use, diabetes duration) on dyslipidemia were studied in 1275 individuals from the Brazilian multi-centre type 1 diabetes study and 171 normal controls. Results Body size and blood pressure were not correlated to lipids and glycemic control. OR (99% CI) for high-LDL were 2.07 (1.21-3.54) and 2.51 (1.46-4.31), in the 4th and 5th HbA1c quintiles, respectively. Hypertriglyceridemia increased in the 5th quintile of HbA1c, OR 2.76 (1.20-6.37). OR of low-HDL-cholesterol were 0.48 (0.24-0.98) and 0.41 (0.19-0.85) in the 3rd and 4th HbA1c quintiles, respectively. HDL-cholesterol correlated positively (0.437) with HbA1c in the 3rd quintile. HDL-cholesterol and insulin dose correlated inversely in all levels of glycemic control. Conclusions Correlation of serum lipids with HbA1c is heterogeneous across the spectrum of glycemic control in type 1 diabetes individuals. LDL-cholesterol and triglycerides worsened alongside HbA1c with distinct thresholds. Association of lower HDL-cholesterol with higher daily insulin dose is consistent and it points out to a role of exogenous hyperinsulinemia in the pathophysiology of the CVRF clustering. These data suggest diverse pathophysiological processes depending on HbA1c, refuting a unified explanation for cardiovascular risk in type 1 diabetes.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::244f8699ed3a93d633cb0ec2e1aafbb5Test
http://www.cardiab.com/content/11Test/1/156

المؤلفون: Adauto Versiani Ramos, Luciana Campanha-Versiani, Eitan Friedman, Marta Sarquis, Luiz De Marco, Bruna Araújo Martins Resende, Débora Marques de Miranda, Luciana Bastos-Rodrigues

المصدر: BMC Medical Genetics, Vol 13, Iss 1, p 101 (2012)
BMC Medical Genetics

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, lcsh:Internal medicine, Waist, lcsh:QH426-470, UCP-1, Alpha-Ketoglutarate-Dependent Dioxygenase FTO, Single-nucleotide polymorphism, Biology, Polymorphism, Single Nucleotide, Ion Channels, Mitochondrial Proteins, Morbid obesity, Brazilian population, Weight loss, Risk Factors, Diabetes mellitus, Internal medicine, Genetics, medicine, Diabetes Mellitus, SNP, Humans, Genetics(clinical), Genetic Predisposition to Disease, lcsh:RC31-1245, Genetics (clinical), Uncoupling Protein 1, Multiethnic sample, Case-control study, Proteins, nutritional and metabolic diseases, Middle Aged, medicine.disease, Obesity, Obesity, Morbid, lcsh:Genetics, Endocrinology, Cardiovascular Diseases, Case-Control Studies, Female, medicine.symptom, FTO, Body mass index, Brazil, Research Article

الوصف: Background Obesity has become a common human disorder associated with significant morbidity and mortality and adverse effects on quality of life. Sequence variants in two candidate genes, FTO and UCP-1, have been reported to be overrepresented in obese Caucasian population. The association of these genes polymorphisms with the obesity phenotype in a multiethnic group such as the Brazilian population has not been previously reported. Methods To assess the putative contribution of both FTO and UCP-1 to body mass index (BMI) and cardiovascular risk we genotyped SNPs rs9939609 (FTO) and rs6536991, rs22705565 and rs12502572 (UCP-1) from 126 morbidly obese subjects (BMI 42.9 ± 5.6 kg/m2, mean ± SE) and 113 normal-weight ethnically matched controls (BMI 22.6 ± 3.5 kg/m2, mean ± SE). Waist circumference, blood pressure, glucose and serum lipids were also measured. Each sample was also genotyped for 40 biallelic short insertion/deletion polymorphism (indels) for ethnic assignment and to estimate the proportion of European, African and Amerindian biogeographical ancestry in the Brazilian population. Results Cases did not differ from controls in the proportions of genomic ancestry. The FTO SNP rs9939609 and UCP-1 SNP rs6536991 were significantly associated with BMI (p= 0.04 and pFTO and UCP-1 SNPs with obesity were noted. There was not an association between rs9939609 (FTO) and rs6536991 (UCP-1) in with maximum weight loss after 1 year in 94 obese patients who underwent bariatric surgery. Conclusion Our data are consistent with FTO rs9939609 and UCP-1 rs6536991 common variants as contributors to obesity in the Brazilian population.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ba9834ac3f1deca7321424c4e4895fdTest
http://www.biomedcentral.com/1471-2350/13/101Test

المؤلفون: Andrea Alcaraz, Federico Augustovski, Lisandro D. Colantonio, Luz Gibbons, Adolfo Rubinstein, Andrés Pichon-Riviere, Joaquín Caporale, Ariel Bardach, Karin Kopitowski, Sebastián García Martí

المصدر: BMC Public Health, Vol 10, Iss 1, p 627 (2010)
SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP
BMC Public Health

مصطلحات موضوعية: Male, medicine.medical_treatment, Cost-Benefit Analysis, primary prevention, cost of illness, 030204 cardiovascular system & hematology, 0302 clinical medicine, Cost of Illness, Risk Factors, cardiovascular disease, cost benefit analysis, 030212 general & internal medicine, pathophysiology, health care economics and organizations, 2. Zero hunger, Aged, 80 and over, education.field_of_study, lcsh:Public aspects of medicine, 1. No poverty, Absolute risk reduction, Middle Aged, 3. Good health, Primary Prevention, risk factor, Cardiovascular Diseases, Female, Research Article, Adult, medicine.medical_specialty, Adolescent, Population, Argentina, 03 medical and health sciences, Young Adult, Environmental health, medicine, Humans, Salt intake, Risk factor, education, Aged, business.industry, Public Health, Environmental and Occupational Health, lcsh:RA1-1270, Models, Theoretical, Years of potential life lost, Relative risk, Attributable risk, Ciencias Médicas, Physical therapy, Smoking cessation, business, Risk Reduction Behavior

الوصف: Background. Cardiovascular disease (CVD) is the primary cause of mortality and morbidity in Argentina representing 34.2% of deaths and 12.6% of potential years of life lost (PYLL). The aim of the study was to estimate the burden of acute coronary heart disease (CHD) and stroke and the cost-effectiveness of preventative population-based and clinical interventions. Methods. An epidemiological model was built incorporating prevalence and distribution of high blood pressure, high cholesterol, hyperglycemia, overweight and obesity, smoking, and physical inactivity, obtained from the Argentine Survey of Risk Factors dataset. Population Attributable Fraction (PAF) of each risk factor was estimated using relative risks from international sources. Total fatal and non-fatal events, PYLL and Disability Adjusted Life Years (DALY) were estimated. Costs of event were calculated from local utilization databases and expressed in international dollars (I$). Incremental cost-effectiveness ratios (ICER) were estimated for six interventions: reducing salt in bread, mass media campaign to promote tobacco cessation, pharmacological therapy of high blood pressure, pharmacological therapy of high cholesterol, tobacco cessation therapy with bupropion, and a multidrug strategy for people with an estimated absolute risk > 20% in 10 years. Results. An estimated total of 611,635 DALY was lost due to acute CHD and stroke for 2005. Modifiable risk factors explained 71.1% of DALY and more than 80% of events. Two interventions were cost-saving: lowering salt intake in the population through reducing salt in bread and multidrug therapy targeted to persons with an absolute risk above 20% in 10 years; three interventions had very acceptable ICERs: drug therapy for high blood pressure in hypertensive patients not yet undergoing treatment (I$ 2,908 per DALY saved), mass media campaign to promote tobacco cessation amongst smokers (I$ 3,186 per DALY saved), and lowering cholesterol with statin drug therapy (I$ 14,432 per DALY saved); and one intervention was not found to be cost-effective: tobacco cessation with bupropion (I$ 59,433 per DALY saved). Conclusions. Most of the interventions selected were cost-saving or very cost-effective. This study aims to inform policy makers on resource-allocation decisions to reduce the burden of CVD in Argentina.
Centro de Endocrinología Experimental y Aplicada (CENEXA)

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca4ac8e57af6fc54cc65dec1e35e0b89Test
http://www.biomedcentral.com/1471-2458/10/627Test

المؤلفون: Minako Yamaoka-Tojo, Naoyoshi Aoyama, Tohru Izumi, Atsuhiko Matsunaga, Naonobu Takahira, Takashi Masuda, Taiki Tojo

المصدر: Cardiovascular Diabetology, Vol 9, Iss 1, p 17 (2010)
Cardiovascular Diabetology

مصطلحات موضوعية: Blood Glucose, Male, lcsh:Diseases of the circulatory (Cardiovascular) system, Endocrinology, Diabetes and Metabolism, chemistry.chemical_compound, Japan, Glucagon-Like Peptide 1, Risk Factors, Odds Ratio, Metabolic Syndrome, digestive, oral, and skin physiology, Fasting, Middle Aged, Glucagon-like peptide-1, Up-Regulation, Cardiovascular Diseases, Obesity, Abdominal, Female, Waist Circumference, Cardiology and Cardiovascular Medicine, hormones, hormone substitutes, and hormone antagonists, Adult, medicine.medical_specialty, endocrine system, Incretin, Enzyme-Linked Immunosorbent Assay, Gastric Inhibitory Polypeptide, Risk Assessment, Gastric inhibitory polypeptide, Insulin resistance, Internal medicine, Diabetes mellitus, medicine, Diabetes Mellitus, Humans, Triglycerides, Glycemic, Aged, Original investigation, Glycated Hemoglobin, Chi-Square Distribution, Cholesterol, business.industry, Cholesterol, HDL, medicine.disease, Uric Acid, Endocrinology, Cross-Sectional Studies, Logistic Models, chemistry, lcsh:RC666-701, Metabolic syndrome, Insulin Resistance, business, Biomarkers

الوصف: Background Glucagon-like peptide-1 (GLP-1) is an incretin hormone that has a wide range of effects on glucose metabolism and cardiovascular function (e.g., improving insulin sensitivity, reduction in appetite, modulation of heart rate, blood pressure and myocardial contractility). Metabolic syndrome (MetS) is associated with an increased risk of developing atherosclerotic cardiovascular diseases. Novel glycemic control drugs, the dipeptidyl-peptidase-4 (DPP-4) inhibitors, work by inhibiting the inactivation of incretin hormones, GLP-1 and glucose-dependent insulinotropic polypeptide (GIP). In spite of good effects of these drugs in diabetic patients, circulating levels of incretins and their role in MetS are largely unknown. Methods To examine relationships between incretin hormones and MetS risk factors, we measured circulating levels of incretins in obese high-risk patients for cardiovascular disease. Fasting serum GLP-1 and GIP levels were measured by ELISA. We performed a cross-sectional analysis of metabolic variables in the fasting state in two subject groups: with MetS (n = 60) and pre-MetS (n = 37). Results Fasting levels of Serum GLP -1 in the peripheral circulation were significantly increased correlated with the accumulation of MetS risk factors components (r = 0. 470, P < 0.001). There was a significant interaction between circulating GLP-1 and GIP, serum high-density lipoprotein cholesterol, triglyceride, and serum uric acid concentrations but not waist circumference, fasting glucose, HbA1c, or presence of diabetes. Conclusion Circulating levels of GLP-1 in relation to the accumulation in MetS factors suggested that MetS patients with elevated levels of GLP-1 are high-risk patients for cardiovascular disease, independent with the presence of diabetes.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6411a89232513b006c35decf2c4574b6Test
http://www.cardiab.com/content/9Test/1/17