Evaluation of the correlation of MACC1, CD44, Twist1, and KiSS-1 in the metastasis and prognosis for colon carcinoma
| العنوان: | Evaluation of the correlation of MACC1, CD44, Twist1, and KiSS-1 in the metastasis and prognosis for colon carcinoma |
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| المؤلفون: | Shiwu Wu, Danna Wang, Bo Zhu, Lei Zhou, Wenqing Song, Xiaomeng Gong, Yichao Wang, Xiaolin Wang |
| المصدر: | Diagnostic Pathology, Vol 13, Iss 1, Pp 1-10 (2018) Diagnostic Pathology |
| بيانات النشر: | BMC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Oncology, Pathology, Time Factors, Multivariate analysis, Colorectal cancer, Metastasis, 0302 clinical medicine, CAC, Stage (cooking), CD44, Kisspeptins, Univariate analysis, biology, Nuclear Proteins, General Medicine, Middle Aged, Immunohistochemistry, Hyaluronan Receptors, Treatment Outcome, 030220 oncology & carcinogenesis, Colonic Neoplasms, Female, Twist1, lcsh:RB1-214, Adult, medicine.medical_specialty, endocrine system, Histology, KiSS-1, Adenocarcinoma, Pathology and Forensic Medicine, 03 medical and health sciences, Cancer stem cell, Internal medicine, Biomarkers, Tumor, medicine, lcsh:Pathology, Humans, Neoplasm Invasiveness, MACC1, Aged, Neoplasm Staging, business.industry, Research, Twist-Related Protein 1, medicine.disease, 030104 developmental biology, Trans-Activators, biology.protein, Neoplasm Grading, business, human activities, Transcription Factors |
| الوصف: | Background Metastasis-associated in colon cancer 1 (MACC1) has been reported to promote tumor cell invasion and metastasis. Cancer stem cells and epithelial-mesenchymal transition (EMT) have also been reported to promote tumor cell proliferation, invasion, and metastasis. KiSS-1, a known suppressor of metastasis, has been reported to be down-regulated in various tumors. However, the associations of MACC1, CD44, Twist1, and KiSS-1 in colonic adenocarcinoma (CAC) invasion and metastasis remain unclear. The purpose of this study is to investigate the roles of MACC1, CD44, Twist1, and KiSS-1 in CAC invasion and metastasis and their associations with each other and with the clinicopathological characteristics of CAC patients. Methods Immunohistochemistry and multivariate analysis were carried out to explore the expression of MACC1, CD44, Twist1, and KiSS-1 in 212 whole-CAC-tissue specimens and the corresponding normal colon mucosa tissues. Demographic, clinicopathological, and follow-up data were also collected. Results The results of this study showed MACC1, CD44, and Twist1 expression to be up-regulated, and KiSS-1 expression was down-regulated in CAC tissues. Positive expression of MACC1, CD44, and Twist1 was found to be positively correlated with invasion, tumor grades, and lymph- node-metastasis (LNM) stages and tumor-node-metastasis (TNM) stages for patients with CAC. Positive expression of KiSS-1 was inversely associated with invasion, tumor size, LNM stage, and TNM stage. The KiSS-1-positive expression group had significantly more favorable OS than did the KiSS-1-negative group. Univariate analysis indicated that overexpression of MACC1, CD44, and Twists1 was negatively associated with longer overall survival (OS) time, and there was a positive relationship between KiSS-1-positive expression and OS time for patients with CAC. Multivariate Cox analysis demonstrated that overexpression of MACC1, CD44, Twist1, and low expression of KiSS-1 and LNM and TNM stages were independent predictors of prognosis in patients with CAC. Conclusions The results in this study indicated that levels of expression of MACC1, CD44, Twist1, and KiSS-1 are related to the duration of OS in patients with CAC. MACC1, CD44, Twist1, and KiSS-1 may be suitable for use as biomarkers and therapeutic targets in CAC. |
| اللغة: | English |
| تدمد: | 1746-1596 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cc5ff60a63c937e909da84828380e5eTest http://link.springer.com/article/10.1186/s13000-018-0722-zTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3cc5ff60a63c937e909da84828380e5e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17461596 |
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