دورية أكاديمية
HIV serostatus and tumor differentiation among patients with cervical cancer at Bugando Medical Centre
| العنوان: | HIV serostatus and tumor differentiation among patients with cervical cancer at Bugando Medical Centre |
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| المؤلفون: | Matovelo Dismas, Magoma Moke, Rambau Peter, Massinde Anthony, Masalu Nestory |
| المصدر: | BMC Research Notes, Vol 5, Iss 1, p 406 (2012) |
| بيانات النشر: | BMC |
| سنة النشر: | 2012 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | HIV, Cervical cancer, Clinical stage, Tumor differentiation, Tanzania, Medicine, Biology (General), QH301-705.5, Science (General), Q1-390 |
| الوصف: | Background Evidence for the association between Human immunodeficiency virus infection and cervical cancer has been contrasting, with some studies reporting increased risk of cervical cancer among HIV positive women while others report no association. Similar evidence from Tanzania is scarce as HIV seroprevalence among cervical cancer patients has not been rigorously evaluated. The purpose of this study was to determine the association between HIV and tumor differentiation among patients with cervical cancer at Bugando Medical Centre and Teaching Hospital in Mwanza, North-Western Tanzania. Methods This was a descriptive analytical study involving suspected cervical cancer patients seen at the gynaecology outpatient clinic and in the gynaecological ward from November 2010 to March 2011. Results A total of 91 suspected cervical cancer patients were seen during the study period and 74 patients were histologically confirmed with cervical cancer. The mean age of those confirmed of cervical cancer was 50.5 ± 12.5 years. Most patients (39 of the total 74–52.7%) were in early disease stages (stages IA-IIA). HIV infection was diagnosed in 22 (29.7%) patients. On average, HIV positive women with early cervical cancer disease had significantly more CD4+ cells than those with advanced disease (385.8 ± 170.4 95% CI 354.8-516.7 and 266.2 ± 87.5, 95% CI 213.3-319.0 respectively p = 0.042). In a binary logistic regression model, factors associated with HIV seropositivity were ever use of hormonal contraception (OR 5.79 95% CI 1.99-16.83 p = 0.001), aged over 50 years (OR 0.09 95% CI 0.02-0.36 p = 0.001), previous history of STI (OR 3.43 95% CI 1.10-10.80 p = 0.035) and multiple sexual partners OR 5.56 95% CI 1.18-26.25 p = 0.030). Of these factors, only ever use of hormonal contraception was associated with tumor cell differentiation (OR 0.16 95% CI 0.06-0.49 p = 0.001). HIV seropositivity was weakly associated with tumor cell differentiation in an unadjusted analysis (OR 0.21 95% CI 0.04-1.02 p = 0.053), but strong ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1756-0500 |
| العلاقة: | http://www.biomedcentral.com/1756-0500/5/406Test; https://doaj.org/toc/1756-0500Test; https://doaj.org/article/083a88f64eb44da989e428d4eff44db5Test |
| DOI: | 10.1186/1756-0500-5-406 |
| الإتاحة: | https://doi.org/10.1186/1756-0500-5-406Test https://doaj.org/article/083a88f64eb44da989e428d4eff44db5Test |
| رقم الانضمام: | edsbas.8ACA30F7 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 17560500 |
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| DOI: | 10.1186/1756-0500-5-406 |