التفاصيل البيبلوغرافية
| العنوان: |
Respiratory atopic disease, Ascaris-immunoglobulin E and tuberculin testing in urban South African children |
| المؤلفون: |
Obihara, C.C., Beyers, N., Gie, R.P., Hoekstra, M.O., Fincham, J.E., Marais, B.J., Lombard, C.J., Dini, L.A., Kimpen, J.L.L. |
| المساهمون: |
Biostatistics Unit, Medical Research Council of South Africa |
| بيانات النشر: |
Blackwell Publishing Ltd. |
| سنة النشر: |
2006 |
| مصطلحات موضوعية: |
Ascaris specific IgE, Atopic disease |
| الوصف: |
Background Epidemiological relation of intestinal helminth infection and atopic disease, both associated with a T-helper (Th) 2 immune response, is controversial, as it has been reported that helminth infection may either suppress or pre-dispose to atopic disease. This relation has not been tested in an area with a high burden of Mycobacterium tuberculosis (MTB) infection, a known Th1-stimulating infection. Objective To study the association of intestinal helminth infection and atopic disease in a community where helminth infection is endemic and MTB infection is high. Methods Three-hundred and fifty-nine randomly selected children aged 6–14 years from a poor urban suburb were tested with allergy questionnaire, skin prick test (SPT) to common aeroallergens, Ascaris-specific IgE (Ascaris-sIgE), fecal examination for pathogenic intestinal helminths and tuberculin skin testing (TST). Histamine bronchoprovocation was tested in the group of children aged 10 years and older. Results were corrected for demographic variables, socioeconomic status, parental allergy, environmental tobacco smoke (ETS) exposure in the household, recent anthelminthic treatment and for clustering in the sampling unit. Results Ascaris-sIgE was elevated in 48% of children, Ascaris eggs were found in 15% and TST was positive in 53%. Children with elevated Ascaris-sIgE had significantly increased risk of positive SPT to aeroallergens, particularly house dust mite, atopic asthma (ever and recent), atopic rhinitis (ever and recent) and increased atopy-related bronchial hyper-responsiveness. In children with negative TST (o10 mm), elevated Ascaris-sIgE was associated with significantly increased risk of atopic symptoms (adjusted odds ratio (ORadj) 6.5; 95% confidence interval (CI) 1.9–22.4), whereas in those with positive TST (X10 mm) this association disappeared (ORadj 0.96; 95% CI 0.4–2.8). Conclusions These results suggest that immune response to Ascaris (Ascaris-sIgE) may be a risk factor of atopic disease in populations exposed to mild Ascaris ... |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN186433978&indx=1&recIds=ETOCRN186433978Test.; Obihara CC, Beyers N, Gie RP, Hoekstra MO, Fincham JE, Marais BJ, et al. Respiratory atopic disease, Ascaris-immunoglobulin E and tuberculin testing in urban South African children. CLINICAL AND EXPERIMENTAL ALLERGY; 0954-7894.; Clinical and Experimental Allergy; https://infospace.mrc.ac.za/handle/11288/595234Test |
| الإتاحة: |
https://infospace.mrc.ac.za/handle/11288/595234Test |
| حقوق: |
Attribution 3.0 United States ; http://creativecommons.org/licenses/by/3.0/usTest/ |
| رقم الانضمام: |
edsbas.6ABF5110 |
| قاعدة البيانات: |
BASE |
