دورية أكاديمية
Contributions of integrin-linked kinase to breast cancer metastasis and tumourigenesis
| العنوان: | Contributions of integrin-linked kinase to breast cancer metastasis and tumourigenesis |
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| المؤلفون: | Hinton, Cimona V, Avraham, Shalom, Avraham, Hava Karsenty |
| بيانات النشر: | Blackwell Publishing Ltd |
| سنة النشر: | 2008 |
| المجموعة: | Harvard University: DASH - Digital Access to Scholarship at Harvard |
| مصطلحات موضوعية: | breast cancer, metastasis, integrins, integrin-linked kinase, PKB/Akt, PI3K, growth factors, GSK-3, loss of heterozygocity |
| الوصف: | Metastasis contributes to more than 90% of mortality in breast cancer. Critical stages in the development of aggressive breast cancer include growth of the primary tumours, and their abilities to spread to distant organs, colonize and establish an independent blood supply. The integrin family of cell adhesion receptors is essential to breast cancer progression. Furthermore, integrin-linked kinase can ‘convert’ localized breast cancer cells into invasive and metastatic cells. Upon stimulation by growth factors and chemokine ligands, integrin-linked kinase mediates the phosphorylation of Akt Ser473, and glycogen synthase kinase-3. The current notion is that overexpression of integrin-linked kinase resulted in an invasive, metastatic phenotype in several cancer model systems in vivo and in vitro, thus, implicating a role for integrin-linked kinase in oncogenic transformation, angiogenesis and metastasis. Here, we will review the role of integrin-linked kinase in breast cancer metastasis. Elucidation of signalling events important for breast tumour metastasis should provide insights into successful breast cancer therapies. ; Version of Record |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1582-1838 |
| العلاقة: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918067/pdfTest/; Journal of Cellular and Molecular Medicine; Hinton, Cimona V, Shalom Avraham, and Hava Karsenty Avraham. 2008. “Contributions of integrin-linked kinase to breast cancer metastasis and tumourigenesis.” Journal of Cellular and Molecular Medicine 12 (5a): 1517-1526. doi:10.1111/j.1582-4934.2008.00300.x. http://dx.doi.org/10.1111/j.1582-4934.2008.00300.xTest.; http://nrs.harvard.edu/urn-3:HUL.InstRepos:15035058Test |
| DOI: | 10.1111/j.1582-4934.2008.00300.x |
| الإتاحة: | https://doi.org/10.1111/j.1582-4934.2008.00300.xTest http://nrs.harvard.edu/urn-3:HUL.InstRepos:15035058Test |
| رقم الانضمام: | edsbas.A4BA7C5 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 15821838 |
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| DOI: | 10.1111/j.1582-4934.2008.00300.x |