Complement and cytokine response in acute Thrombotic Thrombocytopenic Purpura
| العنوان: | Complement and cytokine response in acute Thrombotic Thrombocytopenic Purpura |
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| المؤلفون: | Westwood, John-Paul, Langley, Kathryn, Heelas, Edward, Machin, Samuel J, Scully, Marie |
| المصدر: | British Journal of Haematology |
| بيانات النشر: | Blackwell Publishing Ltd, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Adult, Male, Adolescent, Purpura, Thrombotic Thrombocytopenic, Platelets, Haemostasis and Thrombosis, T cells, Thrombotic Thrombocytopenic Purpura, Middle Aged, ADAMTS13, cytokines, Cohort Studies, ADAM Proteins, Young Adult, hemic and lymphatic diseases, Hemolytic-Uremic Syndrome, Humans, complement, Female, Prospective Studies, Complement Activation, Research Paper, Aged, Atypical Hemolytic Uremic Syndrome |
| الوصف: | Complement dysregulation is key in the pathogenesis of atypical Haemolytic Uraemic Syndrome (aHUS), but no clear role for complement has been identified in Thrombotic Thrombocytopenic Purpura (TTP). We aimed to assess complement activation and cytokine response in acute antibody-mediated TTP. Complement C3a and C5a and cytokines (interleukin (IL)-2, IL-4, IL-6, IL-10, tumour necrosis factor, interferon-γ and IL-17a) were measured in 20 acute TTP patients and 49 remission cases. Anti-ADAMTS13 immunoglobulin G (IgG) subtypes were measured in acute patients in order to study the association with complement activation. In acute TTP, median C3a and C5a were significantly elevated compared to remission, C3a 63·9 ng/ml vs. 38·2 ng/ml (P < 0·001) and C5a 16·4 ng/ml vs. 9·29 ng/ml (P < 0·001), respectively. Median IL-6 and IL-10 levels were significantly higher in the acute vs. remission groups, IL-6: 8 pg/ml vs. 2 pg/ml (P = 0·003), IL-10: 6 pg/ml vs. 2 pg/ml (P < 0·001). C3a levels correlated with both anti-ADAMTS13 IgG (rs = 0·604, P = 0·017) and IL-10 (rs = 0·692, P = 0·006). No anti-ADAMTS13 IgG subtype was associated with higher complement activation, but patients with the highest C3a levels had 3 or 4 IgG subtypes present. These results suggest complement anaphylatoxin levels are higher in acute TTP cases than in remission, and the complement response seen acutely may relate to anti-ADAMTS13 IgG antibody and IL-10 levels. |
| اللغة: | English |
| تدمد: | 1365-2141 0007-1048 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=pmid________::743f8a3592e7f41b0273c67627d78ff8Test http://europepmc.org/articles/PMC4155869Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.pmid..........743f8a3592e7f41b0273c67627d78ff8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652141 00071048 |
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