Human regular U‐500 insulin via continuous subcutaneous insulin infusion versus multiple daily injections in adults with type 2 diabetes: The VIVID study
| العنوان: | Human regular U‐500 insulin via continuous subcutaneous insulin infusion versus multiple daily injections in adults with type 2 diabetes: The VIVID study |
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| المؤلفون: | Anuj Bhargava, Shuyu Zhang, Liza L. Ilag, Howard Zisser, Jennal Johnson, Ludi Fan, James Malone, Trang T. Ly, George Grunberger |
| المصدر: | Diabetes, Obesity & Metabolism |
| بيانات النشر: | Blackwell Publishing Ltd, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Insulin pump, Adult, Blood Glucose, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Injections, Subcutaneous, 030209 endocrinology & metabolism, Type 2 diabetes, 030204 cardiovascular system & hematology, law.invention, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Insulin resistance, Insulin Infusion Systems, Randomized controlled trial, law, insulin resistance, Internal Medicine, randomized trial, Medicine, Humans, Hypoglycemic Agents, Insulin, Glycated Hemoglobin, continuous subcutaneous insulin infusion, business.industry, Repeated measures design, clinical trial, Original Articles, medicine.disease, Subcutaneous insulin, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, U 500 insulin, Anesthesia, insulin therapy, Original Article, business, type 2 diabetes |
| الوصف: | Aim To compare the safety and efficacy of U500‐R delivered by a novel, specifically designed U500‐R insulin pump with U‐500R delivered by multiple daily injections (MDI). Methods The phase 3 VIVID study randomized people with type 2 diabetes to U‐500R by continuous subcutaneous insulin infusion (CSII) or MDI. Participants (aged 18–85 years) had HbA1c ≥7.5% and ≤12.0% and a total daily dose of insulin >200 and ≤600 U/day. After a 2‐week transition to three times daily injections of U‐500R, participants were treated for 24 weeks with U‐500R by CSII or MDI. Treatment arms were compared using mixed model repeated measures analysis. Results The study randomized 420 participants (CSII: 209, MDI: 211) with 365 completers. Mean changes from baseline were: HbA1c, −1.27% (−13.9 mmol/mol) with CSII and −0.85% (−9.3 mmol/mol) with MDI (difference − 0.42% [−4.6 mmol/mol], P |
| اللغة: | English |
| تدمد: | 1463-1326 1462-8902 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5d11d6ca8fa5d2bef198eedc6a920c1Test http://europepmc.org/articles/PMC7065168Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a5d11d6ca8fa5d2bef198eedc6a920c1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14631326 14628902 |
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