Abnormal Expression of Blood Group–related Antigens in Uterine Endometrial Cancers
| العنوان: | Abnormal Expression of Blood Group–related Antigens in Uterine Endometrial Cancers |
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| المؤلفون: | H. Arai, Katsumi Tsukazaki, Shiro Nozawa, Soju Kurihara, Kanji Yamaoka, M. Sakayori |
| المصدر: | Japanese Journal of Cancer Research : Gann |
| بيانات النشر: | Blackwell Publishing Ltd, 1991. |
| سنة النشر: | 1991 |
| مصطلحات موضوعية: | Monoclonal antibody, Cancer Research, Pathology, medicine.medical_specialty, medicine.drug_class, H antigen, Biology, Endometrium, Article, ABO Blood-Group System, related antigens, Lewis Blood Group Antigens, Antigen, Endometrial cancer, Imraunohistochemistry, medicine, Humans, nLc4, Hyperplasia, Globosides, Abnormal expression, medicine.disease, Immunohistochemistry, Pathophysiology, Lc4, Blood group, medicine.anatomical_structure, Oncology, Uterine Neoplasms, Cancer research, Female |
| الوصف: | The expression of A, B, and H group antigens, Lewis group antigens (Lewis(a), Lewis(b), Lewis(x), and Lewis(y)), and Lc4 and nLc4 antigens, the precursor antigens of both groups, was examined immunohistochemically with monoclonal antibodies in 9 normal endometria, 6 endometrial hyperplasias, and 31 endometrial cancers. 1) A, B and/or H antigens were detected in endometrial cancers at an incidence of 51.6%, while no distinct localization of these antigens was observed in normal endometria. H antigen, the precursor of A and B antigens, was particularly frequently detected in endometrial cancers. 2) An increased rate of expression of Lewis group antigens, particularly Lewis(b) antigen, was observed in endometrial cancers compared with its expression in normal endometria. 3) Lc4 and nLc4 antigens were detected in endometrial cancers at rates of 41.9% and 38.7%, respectively, these expressions being increased compared with those in normal endometria. 4) These results suggest that a highly abnormal expression of blood group-related antigens in endometrial cancers occurs not only at the level of A, B, and H antigens and Lewis group antigens, but also at the level of their precursor Lc4 and nLc4 antigens. 5) Lewis(a), Lewis(b), and Lc4 antigens, built on the type-1 chain, are more specific to endometrial cancers than their respective positional isomers, Lewis(x), Lewis(y), and nLc4 antigens, built on the type-2 chain. |
| اللغة: | English |
| تدمد: | 1876-4673 0910-5050 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaaf685adcb40c7590088657640e719eTest http://europepmc.org/articles/PMC5918579Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....aaaf685adcb40c7590088657640e719e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18764673 09105050 |
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