CD45 Isoform Expression in Microglia and Inflammatory Cells in HIV-1 Encephalitis
| العنوان: | CD45 Isoform Expression in Microglia and Inflammatory Cells in HIV-1 Encephalitis |
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| المؤلفون: | Melissa A. Cosenza-Nashat, Meng Liang Zhao, Sunhee C. Lee, Hyeon Sook Suh, Mee Ohk Kim |
| المصدر: | Brain Pathology (Zurich, Switzerland) |
| بيانات النشر: | Blackwell Publishing Ltd, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Gene isoform, AIDS Dementia Complex, Protein tyrosine phosphatase, Biology, Pathology and Forensic Medicine, 03 medical and health sciences, 0302 clinical medicine, In vivo, medicine, Humans, Protein Isoforms, Lymphocytes, Research Articles, 030304 developmental biology, 0303 health sciences, Microglia, General Neuroscience, Macrophages, Brain, Middle Aged, Immunohistochemistry, 3. Good health, Haematopoiesis, medicine.anatomical_structure, Immunology, Cancer research, biology.protein, HIV-1, Leukocyte Common Antigens, Neurology (clinical), Antibody, 030217 neurology & neurosurgery, CD8 |
| الوصف: | CD45 is a membrane tyrosine phosphatase that modulates the function of the hematopoietic cells. In vitro, agonist antibodies to CD45RO or CD45RB isoforms have been shown to suppress microglial activation, but whether microglia in vivo express these isoforms in HIV encephalitis (HIVE) is unknown. Brain sections from control and HIVE were immunostained for CD45 isoforms using exon-specific antibodies (RA, RB, RC and RO). RA and RC were limited to rare lymphocytes, while RB expression was robust in microglia and inflammatory cells. RO was low in control microglia, but increased in HIVE. RO was also localized to macrophages and CD8+ T cells. Targeting CD45 in vivo with isoform-specific antibodies remains a therapeutic option for neuroinflammatory diseases. |
| اللغة: | English |
| تدمد: | 1750-3639 1015-6305 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f934c7479774eb07fd52d6556ef5cd08Test http://europepmc.org/articles/PMC1804203Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f934c7479774eb07fd52d6556ef5cd08 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17503639 10156305 |
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