The 1858T PTPN22 gene variant contributes to a genetic risk of type 1 diabetes in a Ukrainian population
| العنوان: | The 1858T PTPN22 gene variant contributes to a genetic risk of type 1 diabetes in a Ukrainian population |
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| المؤلفون: | I. I. Smirnov, T. A. Moiseenko, Fuencisla Matesanz, A. Caro-Maldonado, Antonio Alcina, María Fedetz, V. N. Chvorostinka |
| المصدر: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| بيانات النشر: | Blackwell Publishing, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Adult, Male, Risk, medicine.medical_specialty, Adolescent, endocrine system diseases, Immunology, Population, Biology, Biochemistry, Gastroenterology, PTPN22, Gene Frequency, immune system diseases, Internal medicine, Genotype, Genetics, medicine, Immunology and Allergy, Humans, Allele, education, Alleles, Aged, Protein Tyrosine Phosphatase, Non-Receptor Type 1, Type 1 diabetes, education.field_of_study, Molecular Epidemiology, Polymorphism, Genetic, Protein Tyrosine Phosphatase, Non-Receptor Type 22, General Medicine, Middle Aged, medicine.disease, Diabetes Mellitus, Type 1, Cohort, Female, Gene polymorphism, Restriction fragment length polymorphism, Protein Tyrosine Phosphatases, Ukraine |
| الوصف: | The 1858T variant of the protein tyrosine phosphatase gene, PTPN22, is associated with an increased risk of several autoimmune diseases. The aim of this study has been to investigate the possible association of 1858C→T PTPN22 polymorphism and type 1 diabetes (T1D) in Caucasians from Ukraine. Overall, the distribution of 1858 PTPN22 genotypes differed significantly between the T1D patient group (n = 296) and the control group (n = 242) (P = 0.0036). When both groups were classified according to sex, the TT genotype and T allele showed a statistically significant higher frequency in T1D female patients (5.9 and 22.8%, respectively) in comparison with the female controls (0 and 11.9%) (P = 0.008 for both analyses). The patients with the TT genotype were significantly younger at the onset of T1D compared with those with genotypes TC and CC (P = 0.035 and 0.019, respectively). In our Ukrainian Caucasian cohort, we confirmed the association between T1D and the PTPN22,1858T allele. © 2006 Blackwell Munksgaard. |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77b0847eaf0692a8e6c837cc47e73f50Test http://hdl.handle.net/10261/79915Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....77b0847eaf0692a8e6c837cc47e73f50 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |