دورية أكاديمية
T102C polymorphism of the 5-HT2A receptor gene may be associated with temporomandibular dysfunction
| العنوان: | T102C polymorphism of the 5-HT2A receptor gene may be associated with temporomandibular dysfunction |
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| المؤلفون: | Mutlu, N, Erdal, ME, Herken, H, Oz, G, Bayazit, YA |
| المساهمون: | Selçuk Üniversitesi |
| بيانات النشر: | BLACKWELL MUNKSGAARD |
| سنة النشر: | 2004 |
| المجموعة: | Selçuk Üniversitesi: SÜ Sosyal Bilimler Enstitüsü - Dergisi Açık Arşivi |
| مصطلحات موضوعية: | temporomandibular dysfunction, serotonin, 5-HT2A receptor, polymorphism |
| الوصف: | WOS: 000225014700007 ; PubMed: 15533210 ; OBJECTIVE: To assess whether a relationship existed between the T102C polymorphism of 5-HT2A receptor gene and temporomandibular dysfunction. METHODS: Sixty-three patients with temporomandibular dysfunction, and 54 healthy volunteer controls were included in the study. Molecular analysis of the T102C polymorphism of the 5-HT2A receptor gene was performed using PCR technique. RESULTS: The C/C genotype was over represented in the patients whereas T/T genotype was over represented in the controls (P < 0.05). The genotype distribution of the patients who had temporomandibular dysfunction was not different than those who did not have temporomandibular dysfunction (P > 0.05). CONCLUSION: The T102C polymorphism may be involved in the etiology of temporomandibular dysfunction. The overrepresentation of the C/C variant of 5-HT2A receptor gene in temporomandibular dysfunction suggests a possible role of the serotonergic system in this disease, particularly at the receptor level. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1354-523X |
| العلاقة: | ORAL DISEASES; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://dx.doi.org/10.1111/j.1601-0825.2004.01037.xTest; https://hdl.handle.net/20.500.12395/19219Test; 10; 349; 352 |
| DOI: | 10.1111/j.1601-0825.2004.01037.x |
| الإتاحة: | https://doi.org/20.500.12395/19219Test https://doi.org/10.1111/j.1601-0825.2004.01037.xTest https://hdl.handle.net/20.500.12395/19219Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.3B515CA4 |
| قاعدة البيانات: | BASE |
| تدمد: | 1354523X |
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| DOI: | 10.1111/j.1601-0825.2004.01037.x |