Liraglutide protects against high-fat diet-induced kidney injury by ameliorating apoptosis
| العنوان: | Liraglutide protects against high-fat diet-induced kidney injury by ameliorating apoptosis |
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| المؤلفون: | Chang Fu, Hongrong Deng, Hua Liang, Meijun Wang, Fen Xu, Mengyin Cai, Ying Tan, Riying Liang |
| المصدر: | Endocrine Connections Endocrine Connections, Vol 9, Iss 9, Pp 946-954 (2020) |
| بيانات النشر: | Bioscientifica Ltd, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, 030204 cardiovascular system & hematology, medicine.disease_cause, lcsh:Diseases of the endocrine glands. Clinical endocrinology, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Internal medicine, Internal Medicine, medicine, Kidney, lcsh:RC648-665, biology, Sirtuin 1, business.industry, Liraglutide, Research, apoptosis, medicine.disease, 030104 developmental biology, medicine.anatomical_structure, glucagon-like peptide-1, Albuminuria, Tubulointerstitial fibrosis, biology.protein, medicine.symptom, business, TXNIP, Oxidative stress, chronic kidney disease, Kidney disease, medicine.drug |
| الوصف: | Background: Obesity is associated with the development and progression of chronic kidney disease. Emerging evidence suggests that glucagon-like peptide-1 receptor agonist could reduce renal damage and albuminuria. Sirtuin 1 (SIRT1) was considered as a crucial regulator in metabolism-related kidney disease. Herein, the role of SIRT1 in liraglutide-ameliorated high-fat diet (HFD)-induced kidney injury was illustrated. Methods: Male C57BL/6 mice were fed HFD for 20 weeks to induce kidney injury that was then treated with liraglutide for 8 weeks to estimate its protective effect on the kidney. Also, the mechanism of the drug in SV40 MES 13 (SV40) mouse mesangial cells was elucidated. Results: Liraglutide treatment ameliorated HFD-induced metabolic disorders, including hyperglycemia, increasing body weight, and insulin resistance. In addition, kidney weight, urine albumin-to-creatinine, and kidney morphological changes such as vacuolated tubules, glomerulomegaly, thickened glomerular basement membrane, and tubulointerstitial fibrosis were also significantly ameliorated. Furthermore, apoptotic cells and apoptosis markers were downregulated in the kidney of liraglutide-treated mice. In addition, the expression of SIRT1 protein was upregulated, whereas thioredoxin-interacting protein (TXNIP), which serves as a mediator of oxidative stress and apoptosis in metabolism disease, was downregulated by liraglutide. In SV40 cells, the effect of liraglutide on reversing the upregulation of cleaved caspase-3 induced by high glucose (30 mM) was hampered when SIRT1 was knocked down; also, the downregulation of TXNIP by liraglutide was blocked. Conclusions: Liraglutide might have a beneficial effect on metabolism-related kidney damage by inhibiting apoptosis via activation of SIRT1 and suppression of TXNIP pathway. |
| اللغة: | English |
| تدمد: | 2049-3614 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cbd4a7e1f68cd0bf549b63eeda67cd5Test http://europepmc.org/articles/PMC7583131Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9cbd4a7e1f68cd0bf549b63eeda67cd5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20493614 |
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