دورية أكاديمية
Adherence and long-term outcomes of growth hormone therapy with easypod™ in pediatric subjects: Spanish ECOS study
| العنوان: | Adherence and long-term outcomes of growth hormone therapy with easypod™ in pediatric subjects: Spanish ECOS study |
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| المؤلفون: | Rodríguez Arnao, María Dolores, Rodríguez Sánchez, Amparo, Díez López, Ignacio, Ramírez Fernández, Joaquín, Bermúdez de la Vega, Jose Antonio, Yeste Fernandez, Diego |
| المساهمون: | Rodríguez Arnao MD, Rodríguez Sánchez A Pediatric Endocrinology Unit, Hospital General Universitario Gregorio Marañón, Madrid, Spain. Díez López I Hospital Universitario Araba, Alava, Spain. Ramírez Fernández J Hospital Universitario Príncipe de Asturias, Oviedo, Spain. Bermúdez de la Vega JA Centro Nuevas Tecnologias, Sevilla, Spain. Yeste Fernández D Vall d’Hebron Hospital Universitari, Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus |
| المصدر: | Scientia |
| بيانات النشر: | Bioscientifica |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Electrònica mèdica, Somatotropina, ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Equipment and Supplies::Electrical Equipment and Supplies::Wearable Electronic Devices, CHEMICALS AND DRUGS::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Peptide Hormones::Pituitary Hormones::Pituitary Hormones, Anterior::Growth Hormone::Human Growth Hormone, PUBLICATION CHARACTERISTICS::Study Characteristics::Multicenter Study, TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::equipos y suministros::equipos eléctricos y suministros eléctricos::dispositivos electrónicos ponibles, COMPUESTOS QUÍMICOS Y DROGAS::hormonas, sustitutos de hormonas y antagonistas de hormonas::hormonas::hormonas peptídicas::hormonas hipofisarias::hormonas adenohipofisarias::hormona del crecimiento::hormona del crecimiento humana, CARACTERÍSTICAS DE PUBLICACIONES::características del estudio::estudio multicéntrico |
| الوصف: | E-health; Easypod; Electronic device ; E-salut; Easypod; Dispositiu electrònic ; E-salud; Easypod; Dispositivo electrónico ; Background: Non-adherence to r-hGH treatments occurs in a variable percentage of subjects. One problem found when evaluating adherence is the great variability in methods of detection and definitions utilized in studies. This study assessed the level of adherence in subjects receiving r-hGH with the easypod™ electronic device. Methods: National, multicenter, prospective and observational study involving 238 subjects (144 with GH deficiency (GHD), and 86 with small for gestational age (SGA), 8 with Turner Syndrome), who received r-hGH with easypod™ for at least 3 months before inclusion. The follow-up period was 4 years. Results: Overall adherence was 94.5%; 97.5% after 6 months, 95.3% after 1 year, 93.7% after 2, 94.4% after 3 and 95.5% after 4 years of treatment. No differences in adherence were observed between prepubertal and pubertal groups and GHD and SGA groups. Change in height after 1 and 2 years, change in height SDS after 1 and 2 years, HV after 1 year, HV SDS after at 1 and 4 years, change in BMI after 1 year and change in BMI SDS at 1 and 2 years showed significant correlation with adherence. No significant differences in adherence according to IGF-I levels were found in follow-up visits or between groups. Conclusions: The easypod™ electronic device, apart from being a precise and objective measure of adherence to r-hGH treatment, allows high compliance rates to be achieved over long periods of time. Adherence significantly impacts growth outcomes associated with r-hGH treatment ; This study was funded by Merck, S.L., Madrid, Spain. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| ردمك: | 978-0-00-486601-7 0-00-486601-0 |
| تدمد: | 2049-3614 |
| العلاقة: | Endocrine Connections;8(9); https://ec.bioscientifica.com/view/journals/ec/8/9/EC-19-0325.xmlTest; Rodríguez Arnao MD, Rodríguez Sánchez A, Díez López I, Ramírez Fernández J, Bermúdez Vega JA de la, Yuste Fernández D, et al. Adherence and long-term outcomes of growth hormone therapy with easypodTM in pediatric subjects: Spanish ECOS study. Endocr Connect. 2019 Sep 1;8(9):1240–9.; https://hdl.handle.net/11351/5043Test; 000486601000003 |
| DOI: | 10.1530/EC-19-0325 |
| الإتاحة: | https://doi.org/10.1530/EC-19-0325Test https://hdl.handle.net/11351/5043Test |
| حقوق: | Attribution-NonCommercial-NoDerivatives 4.0 International ; http://creativecommons.org/licenses/by-nc-nd/4.0Test/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.A5B7DFE0 |
| قاعدة البيانات: | BASE |
Full Text Finder | ردمك: | 9780004866017 0004866010 |
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| تدمد: | 20493614 |
| DOI: | 10.1530/EC-19-0325 |