دورية أكاديمية
Oxygen-permeable microwell device maintains islet mass and integrity during shipping
| العنوان: | Oxygen-permeable microwell device maintains islet mass and integrity during shipping |
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| المؤلفون: | Rojas-Canales, D., Waibel, M., Forget, A., Penko, D., Nitschke, J., Harding, F., Delalat, B., Blencowe, A., Loudovaris, T., Grey, S., Thomas, H., Kay, T., Drogemuller, C., Voelcker, N., Coates, P. |
| المصدر: | http://dx.doi.org/10.1530/ec-17-0349Test. |
| بيانات النشر: | BioScientifica |
| سنة النشر: | 2018 |
| المجموعة: | The University of Adelaide: Digital Library |
| مصطلحات موضوعية: | hypoxia, islet, microwell, shipping, transplantation |
| الوصف: | Islet transplantation is currently the only minimally invasive therapy available for patients with type 1 diabetes that can lead to insulin independence; however, it is limited to only a small number of patients. Although clinical procedures have improved in the isolation and culture of islets, a large number of islets are still lost in the pre-transplant period, limiting the success of this treatment. Moreover, current practice includes islets being prepared at specialized centers, which are sometimes remote to the transplant location. Thus, a critical point of intervention to maintain the quality and quantity of isolated islets is during transportation between isolation centers and the transplanting hospitals, during which 20-40% of functional islets can be lost. The current study investigated the use of an oxygen-permeable PDMS microwell device for long-distance transportation of isolated islets. We demonstrate that the microwell device protected islets from aggregation during transport, maintaining viability and average islet size during shipping. ; Darling M Rojas-Canales, Michaela Waibel, Aurelien Forget, Daniella Penko, Jodie Nitschke, Fran J Harding, Bahman Delalat, Anton Blencowe, Thomas Loudovaris, Shane T Grey, Helen E Thomas, Thomas W H Kay, Chris J Drogemuller, Nicolas H Voelcker, and Patrick T Coates |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2049-3614 |
| العلاقة: | Endocrine Connections, 2018; 7(3):490-503; http://hdl.handle.net/2440/118548Test; Grey, S. [0000-0003-2160-1625]; Drogemuller, C. [0000-0001-9770-4845] |
| DOI: | 10.1530/EC-17-0349 |
| الإتاحة: | https://doi.org/10.1530/EC-17-0349Test https://doi.org/10.1530/ec-17-0349Test http://hdl.handle.net/2440/118548Test |
| حقوق: | © 2018 The authors 2018. Attribution 4.0 International (CC BY 4.0) |
| رقم الانضمام: | edsbas.F9E198E2 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20493614 |
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| DOI: | 10.1530/EC-17-0349 |