Heat shock modulates adipokines expression in 3T3-L1 adipocytes
| العنوان: | Heat shock modulates adipokines expression in 3T3-L1 adipocytes |
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| المؤلفون: | P. Morera, Bruno Ronchi, Umberto Bernabucci, Alessandro Nardone, Nicola Lacetera, L. Basiricò |
| المصدر: | Journal of Molecular Endocrinology. 42:139-147 |
| بيانات النشر: | Bioscientifica, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Leptin, medicine.medical_specialty, Hot Temperature, Cell Survival, Shock termico da caldo, Adipokine, Mice, Endocrinology, Leptina, 3T3-L1 Cells, Internal medicine, Adipociti, HSPA2, Gene expression, Adipocytes, medicine, Animals, HSP70 Heat-Shock Proteins, RNA, Messenger, Heat shock, Molecular Biology, Regulation of gene expression, Adiponectin, Chemistry, 3T3-L1, PPAR gamma, Kinetics, Gene Expression Regulation, Adiponectina, Heat-Shock Response, hormones, hormone substitutes, and hormone antagonists |
| الوصف: | Studies have demonstrated that heat shock is associated with alteration in energy metabolism. In this study, we investigated the effect of heat shock on gene expression and secretion of adiponectin and leptin, and gene expression of Hspa2 and Pparγ in 3T3-L1 adipocytes. Compared with 37 °C, adiponectin mRNA was higher at 39 °C, and lower at 41 °C. Leptin mRNA was higher when adipocytes were exposed to 41 °C compared with 37 and 39 °C. Secretion of adiponectin increased at 39 °C, and when cells were exposed to 41 °C it was not detectable. Leptin secretion increased significantly at 41 °C, compared with 37 and 39 °C. Hspa2 mRNA was increased at 39 °C, and the highest level was reached at 41 °C. Pparγ mRNA exhibited a substantial increase in a temperature-dependent manner. The study provides the first evidence of a possible direct effect of heat shock on adiponectin and leptin gene expression and secretion, and demonstrates that the expression of the two adipokines is differentially regulated at the temperatures tested. |
| تدمد: | 1479-6813 0952-5041 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32bbe2928c7f1a3b420565a006363d9fTest https://doi.org/10.1677/jme-08-0068Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....32bbe2928c7f1a3b420565a006363d9f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14796813 09525041 |
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