المؤلفون: Kreepa G Kooblall, Victoria J Stokes, Omair A Shariq, Katherine A English, Mark Stevenson, John Broxholme, Benjamin Wright, Helen E Lockstone, David Buck, Simona Grozinsky-Glasberg, Christopher J Yates, Rajesh V Thakker, Kate E Lines

المصدر: Endocrine-Related Cancer. 29:557-568

مصطلحات موضوعية: Adult, Aged, 80 and over, Cancer Research, Adolescent, Endocrinology, Diabetes and Metabolism, Middle Aged, MicroRNAs, Young Adult, Endocrinology, Oncology, Child, Preschool, Mutation, Multiple Endocrine Neoplasia Type 1, Quality of Life, Humans, Child, Aged, Transcription Factors

الوصف: Multiple endocrine neoplasia type 1 (MEN1), caused by mutations in the MEN1 gene encoding menin, is an autosomal dominant disorder characterised by the combined occurrence of parathyroid, pituitary and pancreatic neuroendocrine tumours (NETs). Development of these tumours is associated with wide variations in their severity, order and ages (from 80 years), requiring life-long screening. To improve tumour surveillance and quality of life, better circulating biomarkers, particularly for pancreatic NETs that are associated with higher mortality, are required. We, therefore, examined the expression of circulating miRNA in the serum of MEN1 patients. Initial profiling analysis followed by qRT-PCR validation studies identified miR-3156-5p to be significantly downregulated (−1.3 to 5.8-fold, P MEN1 knock-down experiments in BON-1 human pancreatic NET cells resulted in reduced MEN1 (49%, P P miR-3156-5p expression (20%, P miR-3156-5p downregulation is a consequence of loss of MEN1 expression. In silico analysis identified mortality factor 4-like 2 (MOR4FL2) as a potential target of miR-3156-5p, and in vitro functional studies in BON-1 cells transfected with either miR-3156-5p mimic or inhibitors showed that the miR-3156-5p mimic significantly reduced MORF4L2 protein expression (46%, P miR-3156-5p inhibitor significantly increased MORF4L2 expression (1.5-fold, P miR-3156-5p regulates MORF4L2 expression. Thus, the inverse relationship between miR-3156-5p and MORF4L2 expression represents a potential serum biomarker that could facilitate the detection of NET occurrence in MEN1 patients.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da6064ac844ac3ef5945d7eafc8f9477Test
https://doi.org/10.1530/erc-22-0045Test

المؤلفون: Maria-Luisa Lazo-de-la-Vega-Monroy, Hector-Manuel Gomez-Zapata, Juan-Antonio Garcia-Santillan, Maria-Angelica Corona-Figueroa, Gloria Barbosa-Sabanero, J. M. Malacara, Martha-Isabel Gonzalez-Dominguez, Leonel Daza-Benítez, Karen-Alejandra Mata-Tapia

المصدر: Reproduction. 160:455-468

مصطلحات موضوعية: Adult, Leptin, 0301 basic medicine, Embryology, medicine.medical_specialty, Adolescent, Placenta, medicine.medical_treatment, Body Mass Index, Receptor, IGF Type 1, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Pregnancy, Internal medicine, medicine, Birth Weight, Humans, Insulin-Like Growth Factor I, Mechanistic target of rapamycin, Protein kinase B, PI3K/AKT/mTOR pathway, 030219 obstetrics & reproductive medicine, biology, TOR Serine-Threonine Kinases, Insulin, Infant, Newborn, Obstetrics and Gynecology, AMPK, Nutrients, Cell Biology, Cross-Sectional Studies, 030104 developmental biology, medicine.anatomical_structure, Gene Expression Regulation, Reproductive Medicine, Cord blood, biology.protein, Female, Signal Transduction

الوصف: Birth weight (BW) is an important indicator for newborn health. Both high and low BW is associated with increased risks for adult metabolic diseases. AMPK (AMP-activated protein kinase), mTOR (mechanistic target of rapamycin), and insulin/IGF1 (insulin-like growth factor 1) pathways may function as placental sensors of maternal hormonal and nutritional status. However, the physiological role of these pathways in placenta has not been completely elucidated. To evaluate expression and activation of AMPK, mTOR, and insulin/IGF1 pathways and its association with placental weight (PW), BW, and maternal hormonal and metabolic status, we performed a cross-sectional study in placentas from non-obese mothers with SGA (n = 17), AGA (n = 19) and LGA (n = 10) newborns. We analyzed placental expression of total and phosphorylated key proteins from the AMPK, mTOR and insulin/IGF1 pathways. Maternal and cord blood hormones were determined by ELISA. AMPK and LKB1 activation correlated negatively with PW and BW, cord leptin, and pregestational BMI. Placental SIRT1 inversely correlated with BW, cord leptin, neonatal HOMA-IR, and maternal IGF1. PGC1α correlated negatively with PW and BW. Phosphorylated mTOR positively correlated with maternal glucose, PW and BW. IGF1R was lower in SGA. No changes in p-IGF1R, INSRb, total AKT or p-AKT were found, and pPDK1 was lower in SGA and LGA. These results suggest that placental AMPK, insulin/IGF1, and mTOR pathways may influence fetal growth, perhaps regulating placental physiology, even in metabolically healthy pregnancies. Our study highlights these nutrient sensing pathways as potential molecular mechanisms modulating placental adaptations and, thus, long-term metabolic health.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e93608e055cb7d4600122c65cfdbd5a1Test
https://doi.org/10.1530/rep-20-0186Test

المؤلفون: Tim Vigers, Cari Berget, Laurel H. Messer, Cristy Geno, R. Paul Wadwa, Kimberly A. Driscoll, Laura Pyle, Gregory P. Forlenza

المصدر: Pediatr Diabetes

مصطلحات موضوعية: Insulin pump, Adult, Male, Research design, medicine.medical_specialty, Patient Dropouts, Adolescent, Endocrinology, Diabetes and Metabolism, Psychological intervention, 030209 endocrinology & metabolism, Hypoglycemia, Article, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Insulin Infusion Systems, Internal Medicine, Humans, Medicine, 030212 general & internal medicine, Child, Glycemic, Type 1 diabetes, business.industry, medicine.disease, Discontinuation, Diabetes Mellitus, Type 1, Pediatrics, Perinatology and Child Health, Physical therapy, Female, Observational study, business, Psychosocial

الوصف: OBJECTIVE: To describe predictors of hybrid closed loop (HCL) discontinuation and perceived barriers to use in youth with type 1 diabetes. SUBJECTS: Youth with type 1 diabetes (eligible age 2–25 y; recruited age 8–25 y) who initiated the Minimed 670G HCL system were followed prospectively for 6 mo in an observational study. RESEARCH DESIGN AND METHODS: Demographic, glycemic (time-in-range, HbA1c), and psychosocial variables [Hypoglycemia Fear Survey (HFS); Problem Areas in Diabetes (PAID)] were collected for all participants. Participants who discontinued HCL (

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e65bb175e53d4a98b861be0a71f32f5Test
https://doi.org/10.1530/ey.17.10.7Test

المؤلفون: Brown SA, Kovatchev BP, Raghinaru D, Lum JW, Buckingham BA, Kudva YC, Laffel LM, Levy CJ, Pinsker JE, Wadwa RP, Dassau E, Doyle FJ, Anderson SM, Church MM, Dadlani V, Ekhlaspour L, Forlenza GP, Isganaitis E, Lam DW, Kollman C, Beck RW, Trial Research Group. iDCL

المساهمون: University of Virginia [Charlottesville], Department of Molecular Medicine [Tampa], University of South Florida [Tampa] (USF), Stanford School of Medicine [Stanford], Stanford Medicine, Stanford University-Stanford University, Mayo Clinic [Rochester], Harvard Medical School [Boston] (HMS), Université de Lorraine (UL)

المصدر: New England Journal of Medicine
New England Journal of Medicine, Massachusetts Medical Society, 2019, 381 (18), pp.1707-1717. ⟨10.1056/NEJMoa1907863⟩

مصطلحات موضوعية: Adult, Blood Glucose, Male, Pancreas, Artificial, Pediatrics, medicine.medical_specialty, Adolescent, Insulin delivery, 030204 cardiovascular system & hematology, law.invention, Young Adult, 03 medical and health sciences, Insulin Infusion Systems, 0302 clinical medicine, Randomized controlled trial, law, Diabetes mellitus, Multicenter trial, medicine, Humans, Hypoglycemic Agents, Insulin, MESH: Diabetes Mellitus, Type 1/drug therapy, Hypoglycemic Agents/administration & dosage, Insulin/administration & dosage, Pancreas, Artificial/adverse effects, In patient, 030212 general & internal medicine, Aged, Glycemic, Glycated Hemoglobin, Type 1 diabetes, business.industry, Equipment Design, General Medicine, Middle Aged, [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences, medicine.disease, 3. Good health, Diabetes Mellitus, Type 1, Multicenter study, Female, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology

الوصف: Closed-loop systems that automate insulin delivery may improve glycemic outcomes in patients with type 1 diabetes.In this 6-month randomized, multicenter trial, patients with type 1 diabetes were assigned in a 2:1 ratio to receive treatment with a closed-loop system (closed-loop group) or a sensor-augmented pump (control group). The primary outcome was the percentage of time that the blood glucose level was within the target range of 70 to 180 mg per deciliter (3.9 to 10.0 mmol per liter), as measured by continuous glucose monitoring.A total of 168 patients underwent randomization; 112 were assigned to the closed-loop group, and 56 were assigned to the control group. The age range of the patients was 14 to 71 years, and the glycated hemoglobin level ranged from 5.4 to 10.6%. All 168 patients completed the trial. The mean (±SD) percentage of time that the glucose level was within the target range increased in the closed-loop group from 61±17% at baseline to 71±12% during the 6 months and remained unchanged at 59±14% in the control group (mean adjusted difference, 11 percentage points; 95% confidence interval [CI], 9 to 14; P0.001). The results with regard to the main secondary outcomes (percentage of time that the glucose level was180 mg per deciliter, mean glucose level, glycated hemoglobin level, and percentage of time that the glucose level was70 mg per deciliter or54 mg per deciliter [3.0 mmol per liter]) all met the prespecified hierarchical criterion for significance, favoring the closed-loop system. The mean difference (closed loop minus control) in the percentage of time that the blood glucose level was lower than 70 mg per deciliter was -0.88 percentage points (95% CI, -1.19 to -0.57; P0.001). The mean adjusted difference in glycated hemoglobin level after 6 months was -0.33 percentage points (95% CI, -0.53 to -0.13; P = 0.001). In the closed-loop group, the median percentage of time that the system was in closed-loop mode was 90% over 6 months. No serious hypoglycemic events occurred in either group; one episode of diabetic ketoacidosis occurred in the closed-loop group.In this 6-month trial involving patients with type 1 diabetes, the use of a closed-loop system was associated with a greater percentage of time spent in a target glycemic range than the use of a sensor-augmented insulin pump. (Funded by the National Institute of Diabetes and Digestive and Kidney Diseases; iDCL ClinicalTrials.gov number, NCT03563313.).

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84267546ab801b96b04bdc2b2278ee67Test
https://doi.org/10.1530/ey.17.10.13Test

المؤلفون: Martin Adiels, Lena Björck, Soffia Gudbjörnsdottir, Araz Rawshani, Marcus Lind, Jon Edqvist, Ann-Marie Svensson, Naveed Sattar, Annika Rosengren

المصدر: Yearbook of Paediatric Endocrinology.

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Disease, Body Mass Index, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Thinness, Risk Factors, Weight loss, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Risk of mortality, Humans, Obesity, Registries, 030212 general & internal medicine, Aged, Sweden, Advanced and Specialized Nursing, Type 1 diabetes, Proportional hazards model, business.industry, Body Weight, Middle Aged, Prognosis, medicine.disease, Hospitalization, Diabetes Mellitus, Type 1, Cardiovascular Diseases, Female, medicine.symptom, business, Body mass index, Weight gain, Diabetic Angiopathies, Obesity paradox, Follow-Up Studies

الوصف: OBJECTIVE Low weight has been associated with increased mortality risks in type 1 diabetes. We aimed to investigate the importance of weight and weight gain/loss in the Swedish population diagnosed with type 1 diabetes. RESEARCH DESIGN AND METHODS Patients with type 1 diabetes (n = 26,125; mean age 33.3 years; 45% women) registered in the Swedish National Diabetes Registry from 1998 to 2012 were followed from the first day of study entry. Cox regression was used to calculate risk of death from cardiovascular disease (CVD), major CVD events, hospitalizations for heart failure (HF), and total deaths. RESULTS Population mean BMI in patients with type 1 diabetes increased from 24.7 to 25.7 kg/m2 from 1998 to 2012. Over a median follow-up of 10.9 years, there were 1,031 deaths (33.2% from CVD), 1,460 major CVD events, and 580 hospitalizations for HF. After exclusion of smokers, patients with poor metabolic control, and patients with a short follow-up time, there was no increased risk for mortality in those with BMI 25 kg/m2 was associated with a minor increase in risk of mortality, major CVD, and HF. In women, associations with BMI were largely absent. Weight gain implied an increased risk of mortality and HF, while weight loss was not associated with higher risk. CONCLUSIONS Risk of major CVD, HF, CVD death, and mortality increased with increasing BMI, with associations more apparent in men than in women. After exclusion of factors associated with reverse causality, there was no evidence of an obesity paradox.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c425d068b0f9ddace62d5a473e0f947Test
https://doi.org/10.1530/ey.16.10.16Test

المؤلفون: C. Benedikt Westphalen, Annelore Altendorf-Hofmann, Katharina Brüwer, Jens Werner, Thomas Kirchner, Stefan Boeck, Volker Heinemann, Florian Bösch, Gabriele Schubert-Fritschle, Christoph J. Auernhammer, Martin K. Angele, Christine Spitzweg, Thomas Knösel

المصدر: Endocrine-Related Cancer. 26:293-301

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, Adolescent, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Programmed Cell Death 1 Receptor, B7-H1 Antigen, Young Adult, 03 medical and health sciences, Lymphocytes, Tumor-Infiltrating, 0302 clinical medicine, Endocrinology, Cancer immunotherapy, Stomach Neoplasms, Internal medicine, Intestinal Neoplasms, Biomarkers, Tumor, medicine, Humans, Receptor, Grading (tumors), Aged, Aged, 80 and over, business.industry, Immunotherapy, Middle Aged, Survival Analysis, Immune checkpoint, Small intestine, Gene Expression Regulation, Neoplastic, Pancreatic Neoplasms, Neuroendocrine Tumors, Observational Studies as Topic, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Immunohistochemistry, Female, Neoplasm Grading, business, Pancreas

الوصف: Cancer immunotherapy has evolved major breakthroughs in the last years. The cell-surface receptor programmed death-1 (PD-1) and its ligand, programmed death ligand-1 (PD-L1), have been detected in various cancer types. However, the analysis on gastroenteropancreatic neoplasia (GEP-NENs) is limited. Therefore, the aim of this study was to characterize GEP-NENs with regard to PD-1/PD-L1 pathway and tumor-infiltrating lymphocytes (TILs). On protein level, we examined TILs, PD-1 and PD-L1 expression in tumor tissue of 244 GEP-NENs using immunohistochemistry. Expression levels were correlated with clinicopathological parameters including long-term survival in an observational study. In total, 244 patients could be included. Most of the patients had a NEN of the small intestine (52.5%) or the pancreas (29.5%). All tumors could be graded by their morphology and Ki67 index, with 57.8% G1, 34% G2 and 8.2% G3 tumors. High TILs (19.6%) and high PD-1 (16.1%) expression showed a significant correlation with shorter patient survival (P

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8e6d99bda04b43056b2a385562ce650Test
https://doi.org/10.1530/erc-18-0494Test

المؤلفون: Weiqing Wang, Lingyun Tang, Zhugang Wang, Jie Hong, Guang Ning, Yingkai Sun, Rui Wang, Ruixin Liu, Jiqiu Wang, Wen Liu, Wen Li, Shaoqian Zhao

المصدر: Journal of Molecular Endocrinology. 62:79-90

مصطلحات موضوعية: Adult, Fibroblast Growth Factor 9, Male, 0301 basic medicine, medicine.medical_specialty, FGF21, Adolescent, Adipose Tissue, White, Adipocytes, White, Adipose tissue, White adipose tissue, Biology, Fibroblast growth factor, Young Adult, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, Adipose Tissue, Brown, Internal medicine, Adipocyte, medicine, Animals, Humans, Obesity, RNA, Messenger, Molecular Biology, Gene knockdown, Cell Differentiation, Thermogenesis, Stromal vascular fraction, Hypoxia-Inducible Factor 1, alpha Subunit, Mice, Inbred C57BL, stomatognathic diseases, 030104 developmental biology, Gene Expression Regulation, chemistry, Female, 030217 neurology & neurosurgery, Signal Transduction

الوصف: Browning of white adipose tissue has been proven to be a potential target to fight against obesity and its metabolic commodities, making the exploration of molecules involved in browning process important. Among those browning agents reported recently, FGF21 play as a quite promising candidate for treating obesity for its obvious enhancement of thermogenic capacity in adipocyte and significant improvement of metabolic disorders in both mice and human. However, whether other members of fibroblast growth factor (FGF) family play roles in adipose thermogenesis and obese development is still an open question. Here, we examined the mRNA expression of all FGF family members in three adipose tissues of male C57BL/6 mice and found that FGF9 is highly expressed in adipose tissue and decreased under cold stress. Furthermore, FGF9 treatment inhibited thermogenic genes in the process of beige adipocytes differentiation from stromal vascular fraction (SVF) in a dose-dependent manner. Similar results were obtained with FGF9 overexpression. Consistently, knockdown of FGF9 in SVF cells by using lentiviral shRNA increased thermogenic genes in differentiated beige adipocytes. RNA sequencing analysis revealed a significant increment of hypoxia-inducible factor (HIF) pathway in the early stage of beige adipocytes differentiation under FGF9 treatment, which was validated by real-time PCR. FGF9 expression was increased in subcutaneous WAT of obese human and mice. This study shows that adipose-derived FGF9 play as an inhibitory role in the browning of white adipocytes. Activation of hypoxia signaling at early stage of adipose browning process may contribute to this anti-thermogenic effect of FGF9.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3885669eb3441f7a2c94123353756f5aTest
https://doi.org/10.1530/jme-18-0151Test

المؤلفون: Manfred J. Müller, Mario Hasler, Franziska Büsing, John E. Blundell, Alessa Nas, Anja Bosy-Westphal, Franziska A Hägele

المصدر: Yearbook of Paediatric Endocrinology.

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, medicine.medical_specialty, Calorie, Visual Analog Scale, Endocrinology, Diabetes and Metabolism, media_common.quotation_subject, medicine.medical_treatment, Clinical Biochemistry, Energy balance, Appetite, 030209 endocrinology & metabolism, Biochemistry, Random Allocation, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Animal science, Glucagon-Like Peptide 1, Internal medicine, Humans, Insulin, Medicine, Overeating, Exercise, Caloric Restriction, media_common, Balance (ability), Cross-Over Studies, 030109 nutrition & dietetics, Appetite Regulation, business.industry, Body Weight, Biochemistry (medical), Ghrelin, Healthy Volunteers, Area Under Curve, Female, medicine.symptom, Energy Intake, Energy Metabolism, business, Weight gain

الوصف: Background Weight control is hypothesized to be improved when physical activity and energy intake are both high [high energy turnover (ET)]. Objective The impact of three levels of ET on short-term appetite control is therefore investigated at fixed levels of energy balance. Design In a randomized crossover trial, 16 healthy adults (25.1 ± 3.9 y of age; body mass index, 24.0 ± 3.2 kg/m2) spent three daylong protocols for four times in a metabolic chamber. Four conditions of energy balance (ad libitum energy intake, zero energy balance, −25% caloric restriction, and +25% overfeeding) were each performed at three levels of ET (PAL 1.3 low, 1.6 medium, and 1.8 high ET; by walking on a treadmill). Levels of appetite hormones ghrelin, GLP-1, and insulin (total area under the curve) were measured during 14 hours. Subjective appetite ratings were assessed by visual analog scales. Results Compared with high ET, low ET led to decreased GLP-1 (at all energy balance conditions: P < 0.001) and increased ghrelin concentrations (caloric restriction and overfeeding: P < 0.001), which was consistent with higher feelings of hunger (zero energy balance: P < 0.001) and desire to eat (all energy balance conditions: P < 0.05) and a positive energy balance during ad libitum intake (+17.5%; P < 0.001). Conclusion Appetite is regulated more effectively at a high level of ET, whereas overeating and consequently weight gain are likely to occur at low levels of ET. In contrast to the prevailing concept of body weight control, the positive impact of physical activity is independent from burning up more calories and is explained by improved appetite sensations.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6e2d80837d49f389b79f56f297125b6Test
https://doi.org/10.1530/ey.17.11.5Test

المؤلفون: Michela Deiana, Luca Dalle Carbonare, Maria Vittoria Davì, Elisa Cosaro, Valentina Micheletti, Monica Mottes, Giuseppe Francia, Samuele Cheri, Maria Teresa Valenti

المصدر: Endocrine-Related Cancer. 25:269-277

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Cancer Research, medicine.medical_specialty, Bone density, RUNX2, Endocrinology, Diabetes and Metabolism, Cellular differentiation, Core Binding Factor Alpha 1 Subunit, 030209 endocrinology & metabolism, Bone and Bones, osteogenesis, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Downregulation and upregulation, Bone Density, Internal medicine, Acromegaly, medicine, Humans, Progenitor cell, Aged, Bone mineral, mesenchymal stem cells, business.industry, Mesenchymal stem cell, Cell Differentiation, Middle Aged, medicine.disease, Up-Regulation, 030104 developmental biology, Oncology, acromegaly, Female, business

الوصف: Acromegalic patients, characterized by excessive secretion of GH and IGF-1, show a high fracture risk but bone mineral density is a poor predictor for bone fractures in these patients. The effects of an excess of GH/IGF1 on skeleton as well as on osteogenic progenitors, i.e. mesenchymal stem cells, have not been investigated in these patients. We aimed to elucidate the skeletal conditions of acromegalic patients by means of bone microarchitecture analysis and evaluation of MSCs osteogenic commitment. In particular, we performed histomorphometric analyses, and we quantified the expression levels of the osteogenic transcription factor RUNX2 in circulating MSCs. Our results showed an abnormal microarchitecture and demonstrated that bone impairment in acromegalic patients is associated with the upregulation ofRUNX2expression. Furthermore, osteoblastic activity was significantly reduced in patients under pharmacological treatment, compared to untreated patients. In conclusion, this study demonstrates the key role ofRUNX2gene overexpression in causing bone impairment in acromegalic patients. It also suggests a therapeutic approach for the improvement of bone quality, focused on the osteoblastic lineage rather than the inhibition of osteoclastic activity.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65908d51a2002c79eb49cb5a7ac1838eTest
https://doi.org/10.1530/erc-17-0523Test

المؤلفون: Andrew K. Blannin, Adrian Holliday

المصدر: Journal of Endocrinology. 235:193-205

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Adolescent, Endocrinology, Diabetes and Metabolism, media_common.quotation_subject, Appetite, 030209 endocrinology & metabolism, Gastrointestinal Hormones, Eating, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Glucagon-Like Peptide 1, Internal medicine, Humans, Medicine, Aerobic exercise, Peptide YY, Exercise, Morning, media_common, Meal, Cross-Over Studies, business.industry, 030229 sport sciences, Crossover study, Ghrelin, Energy Intake, Energy Metabolism, business, Hormone

الوصف: The purpose of the study is to investigate the effect of acute bouts of high-intensity aerobic exercise of differing durations on subjective appetite, food intake and appetite-associated hormones in endurance-trained males. Twelve endurance-trained males (age = 21 ± 2 years; BMI = 21.0 ± 1.6 kg/m2; VO2max = 61.6 ± 6.0 mL/kg/min) completed four trials, within a maximum 28 day period, in a counterbalanced order: resting (REST); 15 min exercise bout (15-min); 30 min exercise bout (30-min) and 45 min exercise bout (45-min). All exercise was completed on a cycle ergometer at an intensity of ~76% VO2max. Sixty minutes post exercise, participants consumed an ad libitum meal. Measures of subjective appetite and blood samples were obtained throughout the morning, with plasma analyzed for acylated ghrelin, total polypeptide tyrosine-tyrosine (PYY) and total glucagon-like peptide 1 (GLP-1) concentrations. The following results were obtained: Neither subjective appetite nor absolute food intake differed between trials. Relative energy intake (intake – expenditure) was significantly greater after REST (2641 ± 1616 kJ) compared with both 30-min (1039 ± 1520 kJ) and 45-min (260 ± 1731 kJ), and significantly greater after 15-min (2699 ± 1239 kJ) compared with 45-min (condition main effect, P P P = 0.011); the greatest, most enduring suppression, was observed in 45-min. PYY concentration was unchanged with exercise. In conclusion, high-intensity aerobic cycling lasting up to 45 min did not suppress subjective appetite or affect absolute food intake, but did reduce relative energy intake, in well-trained endurance athletes. Findings question the role of appetite hormones in regulating subjective appetite in the acute post-exercise period.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61e99faa0ebeabed86ef03e5ca2606ddTest
https://doi.org/10.1530/joe-16-0570Test