Biological and clinical impact of imbalanced progesterone receptor isoform ratios in breast cancer
| العنوان: | Biological and clinical impact of imbalanced progesterone receptor isoform ratios in breast cancer |
|---|---|
| المؤلفون: | Claudia Lanari, Caroline A. Lamb, Britta M. Jacobsen, Victoria Teresa Fabris, Alfredo A. Molinolo |
| المصدر: | CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET |
| بيانات النشر: | BioScientifica, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Cancer Research, CIENCIAS MÉDICAS Y DE LA SALUD, medicine.drug_class, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Mammary gland, Estrogen receptor, Ciencias de la Salud, ISOFORMS, purl.org/becyt/ford/3.3 [https], 03 medical and health sciences, ANTIPROGESTINS, 0302 clinical medicine, Endocrinology, Breast cancer, PROGESTERONE RECEPTOR, BREAST CANCER, Progesterone receptor, medicine, PROGNOSTIC MARKERS, Medroxyprogesterone acetate, PR ISOFORM RATIO, skin and connective tissue diseases, Receptor, IN VIVO BREAST CANCER MODELS, PROGESTINS, business.industry, Hormone replacement therapy (menopause), PATIENT-DERIVED XENOGRAFTS, medicine.disease, Otras Ciencias de la Salud, 030104 developmental biology, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Cancer research, purl.org/becyt/ford/3 [https], business, Progestin, medicine.drug |
| الوصف: | There is a consensus that progestins and thus their cognate receptor molecules, the progesterone receptors (PRs), are essential in the development of the adult mammary gland and regulators of proliferation and lactation. However, a role for natural progestins in breast carcinogenesis remains poorly understood. A hint to that possible role came from studies in which the synthetic progestin medroxyprogesterone acetate was associated with an increased breast cancer risk in women under hormone replacement therapy. However, progestins have also been used for breast cancer treatment and to inhibit the growth of several experimental breast cancer models. More recently, PRs have been shown to be regulators of estrogen receptor signaling. With all this information, the question is how can we target PR, and if so, which patients may benefit from such an approach? PRs are not single unique molecules. Two main PR isoforms have been characterized, PRA and PRB, which exert different functions and the relative abundance of one isoform with respect to the other determines the response of PR agonists and antagonists. Immunohistochemistry with standard antibodies against PR do not discriminate between isoforms. In this review, we summarize the current knowledge on the expression of both PR isoforms in mammary glands, in experimental models of breast cancer and in breast cancer patients, to better understand how the PRA/PRB ratio can be exploited therapeutically to design personalized therapeutic strategies. Fil: Lamb, Caroline Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina Fil: Fabris, Victoria Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina Fil: Jacobsen, Britta M.. State University of Colorado - Fort Collins; Estados Unidos Fil: Molinolo, Alfredo. University of California at San Diego; Estados Unidos Fil: Lanari, Claudia Lee Malvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina |
| وصف الملف: | application/pdf |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe333eb1c41de06a98a0e2d03162637cTest https://erc.bioscientifica.com/view/journals/erc/aop/erc-18-0179.xmlTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fe333eb1c41de06a98a0e2d03162637c |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |